Biological and biomechanical assessment of a long-term bioresorbable silk-derived surgical mesh in an abdominal body wall defect model

Horan, Rebecca L.; Bramono, Diah S.; Stanley, Jennifer; Simmons, Quincey; Chen, J.; Boepple, Heather E.; Altman, Gregory H.

doi:10.1007/s10029-008-0459-9

Cited by 57 publications

(50 citation statements)

References 27 publications

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“…Its biomechanical properties are similar to those of host tissue, with good biocompatibility and evidence of a mild, self-limiting foreign body response. 1,2 SERI provides strong but pliable postoperative soft-tissue support with gradual enzymatic resorption, 3 permits progressive ingrowth and replacement of SERI by host tissue that is 2–3 times that of the initial SERI thickness, and is stronger than native ovine fascia. 1–3 The SERI Product Evaluation Program gathers feedback from surgeons who use this device.…”

Section: Sirmentioning

confidence: 99%

A 12-month Survey of Early Use and Surgeon Satisfaction with a New Highly Purified Silk Matrix

Bengtson

Baxter

Clemens

et al. 2014

Plastic and Reconstructive Surgery Global Open

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Section: Sirmentioning

confidence: 99%

A 12-month Survey of Early Use and Surgeon Satisfaction with a New Highly Purified Silk Matrix

Bengtson

Baxter

Clemens

et al. 2014

Plastic and Reconstructive Surgery Global Open

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“…Natural macromolecule materials such as collagen, gelatin, and albumin are often preferred [10,11], which can be processed under mild conditions. Natural silk proteins are now considered a suitable material for drug delivery applications because of several important properties, such as biodegradation [12,13,14], biocompatibility [15,16,17], aqueous-based ambient purification [18], and effective drug stabilization [19,20]. Silk protein fibroin derived from wild silkworm sources is termed non-mulberry silk.…”

Section: Introductionmentioning

confidence: 99%

Natural Non-Mulberry Silk Nanoparticles for Potential-Controlled Drug Release

Wang

Yin

Xue

et al. 2016

IJMS

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Natural silk protein nanoparticles are a promising biomaterial for drug delivery due to their pleiotropic properties, including biocompatibility, high bioavailability, and biodegradability. Chinese oak tasar Antheraea pernyi silk fibroin (ApF) nanoparticles are easily obtained using cations as reagents under mild conditions. The mild conditions are potentially advantageous for the encapsulation of sensitive drugs and therapeutic molecules. In the present study, silk fibroin protein nanoparticles are loaded with differently-charged small-molecule drugs, such as doxorubicin hydrochloride, ibuprofen, and ibuprofen-Na, by simple absorption based on electrostatic interactions. The structure, morphology and biocompatibility of the silk nanoparticles in vitro are investigated. In vitro release of the drugs from the nanoparticles depends on charge-charge interactions between the drugs and the nanoparticles. The release behavior of the compounds from the nanoparticles demonstrates that positively-charged molecules are released in a more prolonged or sustained manner. Cell viability studies with L929 demonstrated that the ApF nanoparticles significantly promoted cell growth. The results suggest that Chinese oak tasar Antheraea pernyi silk fibroin nanoparticles can be used as an alternative matrix for drug carrying and controlled release in diverse biomedical applications.

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“…Similar methodology has been used in multiple published studies to describe the biaxial strength of synthetic and biologic scaffolds. 23,[25][26][27] The native ventricles were excised and tested the same day as euthanasia. The C-ECM was tested within 48 h of the completion of decellularization.…”

Section: Ball Burst Mechanical Testingmentioning

confidence: 99%