Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes

Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(iii) complex in human cancer cell lines

“…35 In our previous study we have determined the free radicalscavenging activity of selenosemicarbazones and their metal complexes by ABTS method. 3 Our results showed that H8qasesc is an excellent ABTS cation radical-scavenger, with greater efficacy than Vitamin C. Coordination of the ligand to Pt(II) and Pd(II) canceled antioxidant activity of corresponding complexes.…”

“…Although the activity of the ligand on several cancer cell lines was previously investigated, due to differences in applied methodologies it is not possible to compare our current results with the previously published data. 3 Therefore, instead to declare for activity of investigated treatments just according to relative number of viable cells in treated samples, we can also review their profiles of activity.…”

“…Selenosemicarbazones are Schiff bases obtained by condensation reaction of carbonyl compounds and selenosemicarbazides. They showed antiparasitic, 1 antifungal, 2,3 antibacterial, 3-6 antimalarial, 7-10 anticancer, 3, 7, 10-23 antioxidant 3,14 and antidiabetic 14 activity.…”

“…In order to obtain more active species, complexes of Pt(II), Pd(II), Zn(II), Cd(II), Au(I), Ni(II), Co(III), Ga(III), Sn(IV) and Cu(II) have been prepared and tested against malaria, 10, 24, 25 microorganisms, [3][4][5] as well as cancer cell lines. 3,11,[16][17][18][19][20][21][22][23]26 As a result of such approach metal complexes with activities better than corresponding ligands have been developed.…”

“…In LS174, FemX and MDA-143 cell lines, treatment with Hfpsesc resulted in accumulation of cells in S-to-G2/M phase, while for U2OS and U2OS-Pt cells were accumulated exclusively in the S phase. The ligand H8qasesc showed the same degree of antiproliferative activity against U251 cell line as CDDP, with a 20 times higher antioxidant potential when compared to Vitamin C. 3 Scheme 1. Structures of mono-and bis(selenosemicarbazone) ligands.…”