Biological activity of green synthesized silver nanoparticles and different plant extracts of Solanum khasianum Clarke

Abstract

Solanum khasianum Clarke. (Solanaceae), an important medicinal plant used to treat several diseases. Leaf, root, fruit and bark extracts of S. khasianum and the green synthesized silver nanoparticles were assayed for its antibacterial activity against gram positive and gram negative bacteria, using agar well diffusion method. Among all the solvent extracts tested, methanolic extracts were found to possess elevated activity. The optimal antibacterial activity is exhibited by silver nanoparticles against Pseudomonas flourescens with a maximal zone of inhibition (22mm). In the present study, the efficacy of green synthesized silver nanoparticles over the different plant extracts of S. khasianum against different bacterial strains was reported. This investigation discloses the potentiality of using silver nanoparticles as an antibacterial agent.

Preliminary phytochemical screening and antibacterial activity of tinospora cordifolia

“…The maximum antibacterial activity was shown towards B. Subtilis at 80 µg/ml concentration, followed by B. Sphaericus, P. vulgaris and E. Coli (Graph I). Similar findings were reported in the methanolic extract of Solanum khasianum leaf [16] and Mappia foetida leaf and stem extracts [17] . In contrast to the other bacterial strains tested, the stem butanolic extract demonstrated strong anti-microbial activity with high extent of inhibitory zones against E. coli followed by B. subtilis (Fig 3).…”

GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts

“…The result indicates that the S. khasianum root extract exhibited remarkable antibacterial property against P. aeruginosa and E. coli. Therefore, root methanolic extract of S. khasianum was considered as the most effective extract than leaf extract with regard to high anti-bacterial activity (Pavani and Shasthree 2021 ). This indicates that the root extract had more antibacterial compounds than leaf extract.…”

“…The plant was known to possess potential alkaloids (solasodine, solasonine, solanine, solamargine and khasianine) that represent an alternative source of medicine (Kaunda and Zhang 2019 ; Chirumamilla et al 2021 ). The berries of S. khasianum was reported to possess anticancer (Rosangkima and Jagetia 2015 ), antibacterial (Pavani and Shasthree 2021 ), anti-inflammatory (Chirumamilla et al 2022 ), antioxidant, anti-diabetic and anti-cholinesterase properties (Gogoi et al 2021 ). Besides these, the plant is used traditionally to treat several other diseases like filaria, smallpox, whooping cough, rheumatism, trachoma, bronchitis, snake bites, skin and tooth infections (Chirumamilla et al 2021 ).…”

Stability estimation through multivariate approach among solasodine-rich lines of Solanum khasianum (C.B. Clarke): an important industrial plant

“…Solasodine was found to possess many pharmacological properties like anti-inflammatory, antioxidant, antinociceptive, antimicrobial, cytotoxic, anti-obesity, antiandrogenic, and hepatoprotective properties ( Srivastava et al., 2016 ; Kumar et al., 2019 ; Gogoi et al., 2021 ). Moreover, previous reports suggested that the berries possess anti-diabetic, anti-inflammatory, anti-cholinesterase, anticancer, and antibacterial properties ( Rosangkima and Jagetia, 2015 ; Gogoi et al., 2021 ; Pavani and Shasthree, 2021 ). As an ethnomedicine, the plant has been used for treating diseases like whooping cough, bronchitis, smallpox, trachoma, snake bites, rheumatism, and tooth and skin infections ( Schmelzer and Gurib, 2008 ; Chirumamilla et al., 2021 ; Lal et al., 2022a ).…”