Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.

Jin, Mingliang; Huang, Qingsheng; Zhao, Ke; Shang, Peng

doi:10.1016/j.ijbiomac.2012.11.023

Cited by 265 publications

(175 citation statements)

References 82 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…Biological activities of the polysaccharide partly depend on its MW [7]. Polysacchrides from Lycium barbarum have been demonstrated to have anticancer activity both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Recent studies have indicated that biological activities of the polysaccharide partly depend on its MW [7]. LBP has an MW range of 10-2300 kDa, and its antitumor activity is probably related to MW [7]. Zhang [8] observed the effects of LBP fractions on human liver cancer cells (SMMC-7721) and found that LBP-a4 with an MW of 10.2 kDa could inhibit the proliferation of SMMC-7721 cells in a dose-and time-dependent manner, but LBP-p8 with an MW of 6.50 × 10 3 kDa could promote the growth of SMMC-7721 cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Deng

Li²,

Luo

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

The antitumor activity of Lycium barbarum polysaccharide (LBP) has been reported, but the structure-bioactivity relationship has still not been fully elucidated. In this study, four watersoluble LBP fractions with serial different molecular weights (MWs) were separated from LBP, designated LBP-2, LBP-3, LBP-4, and LBP-5. After a characteristic analysis, the relationship between MW and antitumor activity of LBP was investigated both in vitro using murine hepatoma H22 cells and in vivo using H22 tumor-bearing mice. In vitro, the results showed that all the LBP fractions had significant inhibition on H22 cells, in which LBP-3 had the best activity. LBP-3 could induce apoptosis, mitochondrial membrane potential destruction, and S phase arrest in H22 cells. In vivo, the results showed that LBP-2, LBP-3, LBP-4, and LBP-5 could inhibit the tumor growth in H22 tumor-bearing mice by 18.18%, 37.97%, 9.09%, and 14.44%, respectively. However, only LBP-3 was able to decrease the tumor weight significantly in H22 tumor-bearing mice. Meanwhile, all the LBP fractions did not show significant toxicity to murine splenocytes, thymus, and spleen. Taken together, these results demonstrated that the antitumor activity of LBP was closely related to its MW, and LBP-3 with medium MW (40-350 kDa) was the main active fraction. ARTICLE HISTORY

show abstract

“…Biological activities of the polysaccharide partly depend on its MW [7]. Polysacchrides from Lycium barbarum have been demonstrated to have anticancer activity both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Deng

Li²,

Luo

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

show abstract

“…barbarum polysaccharide (LBP), the major active ingredient extracted from L. barbarum, has traditionally been used in Chinese medicine for protection of eyesight, regulation of immune system and treatment of cancer. Moreover, it has been reported that LBP is non-toxic to the liver and kidney [7][8][9][10][11]. Pharmacological studies have showed that LBP exhibits protective effects on the reproductive system via regulation of stress response and hormone balance [12,13].…”

Section: Introductionmentioning

confidence: 99%

<i>Lycium barbarum</i> polysaccharide attenuates cisplatininduced apoptosis in ovary granulosa cells via alleviation of endoplasmic reticulum stress

Li-qiong¹,

Zhang²,

Zheng³

et al. 2016

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To investigate the effect of Lycium barbarum polysaccharide (LBP) on apoptosis of ovary granulose cells (GCs), as well as its underlying mechanism. Methods: GCs were isolated from Sprague Dawley (SD) rats and divided into three groups: control group, model group (DDP) and LBP group. Cell morphology was observed by H & E staining under optical microscope. Expression of follicle stimulating hormone receptor (FSHR) was assessed by immunohistochemistry (IHC), while cell viability was assayed using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). Apoptosis was determined by flow cytometry. Expressions of glucose-regulated protein 78(GRP78), C/EBP

show abstract

“…4 The fruit of Lycium barbarum (Solanaceae), also called goji berry or wolfberry, is a well-known traditional Chinese medicine as well as valuable nourishing tonic, which has been used for more than 2300 years in East Asia. 5,6 Many studies on pharmacology and phytochemistry have demonstrated that Lycium barbarum polysaccharides (LBP) had various bioactivities, such as antioxidant, 7,8 immunomodulation, [9][10][11][12] and hepatoprotection. 13 No study to date has reported the effects of Lycium barbarum on BT in thioacetamide (TAA)-induced liver injury in rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats

et al. 2015

View full text Add to dashboard Cite

Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.

show abstract

Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.

Cited by 265 publications

References 82 publications

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

<i>Lycium barbarum</i> polysaccharide attenuates cisplatininduced apoptosis in ovary granulosa cells via alleviation of endoplasmic reticulum stress

Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats

Contact Info

Product

Resources

About