Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats

Abstract

Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.

The ameliorative potential of Alda-1 on experimentally induced liver fibrosis in adult male mice. A histological, immunohistochemical and biochemical study.

“…Among various hepatotoxic agents, thioacetamide (TAA) is recognized to be the most potent because of its outstanding solubility in water, and its cumulative effect [30] . Moreover, experimentally initiation of liver fibrosis by TAA administration results in biochemical and histological alterations as those of human liver fibrosis [31,32] .…”

Liver proteomic analysis reveals acute liver failure induced by lipopolysaccharide/D-galactosamine in rats involved in neutrophil extracellular trap formation

“…[1][2][3] Patients with drug-induced ALF, account for a significant proportion of fatal hepatic injury cases, and previous studies confirm that ALF is associated with an increased risk of developing liver dysfunction and even hepatocellular carcinoma, compared to healthy individuals. 11,15,21 While previous research focused on the disparities between ALF patients and healthy individuals, not much is known about the potential mechanisms and alterations in specific signalling pathways, in the context of drug-induced ALF. To our knowledge, the liver proteomic data presented in this study are the first to report molecular differences between rats with 12 h LPS/D-Gal-induced ALF and controls at the proteome level.…”