BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO&amp;#091;1,2-B]QUINOLINE DERIVATIVES

Cañete, Álvaro; Armijo, Francisco; Valle, M.; Tapia, Ricardo A.; Theoduloz, Cristina; Pessoa, Carlos D; Cantuarias, Lorena B.; Recabarren, G

doi:10.4067/s0717-97072012000200015

Cited by 10 publications

(3 citation statements)

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“…Indolizino[1,2-b] quinoline derivatives, were prepared in a one-pot reaction of 2,3-dichloro-1,4naphthoquinone with ketones under microwave irradiation (40-90% yields); Scheme 53 [94].…”

Section: With Carbon and Nitrogen Nucleophilesmentioning

confidence: 99%

“…2,3-dichloro-1,4-naphthoquinone (1) also reacted with tertiary amines in CH2Cl2 resulting in the formation of N:N-dialkyl-2-chloro-1,4-naphthoquinone (94) [43] and when it reacted with dilituric acid (91) produced 2-dilituro-3-chloro-1,4-naphthoquinone (92, 94%) [44]; Scheme 21. Scheme 21: Nuclophilic reactions of 2,3-dichloro-1,4-naphthoquinone (1).…”

Section: Introductionmentioning

confidence: 99%

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Synthetic and Biological Utility of 2,3-Dichloro-1,4-Naphthoquinone: A Review

Maurya

2020

Int. J. Res. Granthaalayah

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2,3-Dichloro-1,4-naphthoquinones (dichlone) have attracted considerable attention for the construction of biologically active tricyclic and tetracyclic 1,4-quinones and other derivatives. A diversified reaction of 2,3-dichloro-1,4-naphthoquinones such as cycloaddition, condensation, photo induced and nucleophilic substitution reactions with suitable nucleophiles viz. carbon, nitrogen, oxygen, sulfur, selenium etc have been explored. Various synthesized compounds have also explored for their biological activity such as antifungal, antibacterial, anticancer, antiplatlet, anti-inflamentry, anti-allergic and anti HIV. This review describes the chemistry and biological activity of compounds synthesized from 2,3-dichloro-1,4-naphthoquinones during the last three decades.

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“…Indolizino[1,2-b] quinoline derivatives, were prepared in a one-pot reaction of 2,3-dichloro-1,4naphthoquinone with ketones under microwave irradiation (40-90% yields); Scheme 53 [94].…”

Section: With Carbon and Nitrogen Nucleophilesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthetic and Biological Utility of 2,3-Dichloro-1,4-Naphthoquinone: A Review

Maurya

2020

Int. J. Res. Granthaalayah

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“…According of this idea, an aziridinyl group at 5 positions plays an important role above selectivity and potency to design anticancer prodrugs. In another hand, the presence of electro withdrawing group in 3 position and heteroatom groups in 2 positions is also important to cancer selectivity 2,7 . …”

Section: Introductionmentioning

confidence: 99%

Electrochemical and Spectroscopic Properties of Indolizino[1,2-B] Quinole Derivates

Alcalde

Molero

Cañete

et al. 2013

J. Chil. Chem. Soc.

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A series of indolizino [1,2-b] quinole derivates compounds were characterized by various electrochemical and spectroscopic techniques. Electrochemical studies reveal that there are two redox processes controlled by diffusion, the first step corresponds to the formation of a semiquinone radical Q•− , while the second step corresponds to the formation of quinone dianion, Q 2− . The presence of acceptor groups such as -CN and -COOH shifted reduction potentials, due to a more favorable electronic stabilization. There was no significant effect of the substituents on the absorption spectra of indolizino[1,2-b] quinole derivates. The substituents influenced the fluorescence properties from indolizino[1,2-b] quinole derivates. The emission and excitation spectra obtained of these compounds suggested that the molecule emits from a locally excited state having identical geometry with that of ground state geometry. Finally it was observed that the group with higher acceptor capacity (-CN), has the highest quantum yield, which is indicating that this group always stabilized electronic state with a higher conjugation.

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