Synthetic and Biological Utility of 2,3-Dichloro-1,4-Naphthoquinone: A Review

Maurya, Hardesh K.

doi:10.29121/granthaalayah.v7.i10.2019.399

Cited by 4 publications

(3 citation statements)

References 130 publications

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“…This compound can be used as solidstate fluorescence material (Figure 13) [60]. The nucleophilic substitution of 2,3-dichloro-1,4-naphthoquinone is a synthetic strategy for introducing nitrogen, oxygen, carbon, sulfur, and selenium nucleophiles at C2 and C3 positions [61].…”

Section: Chemical Modification Of Nqs Structures With Nitrogen Groupsmentioning

confidence: 99%

“…Campora et al (2021) reported the synthesis of NQ derivatives bearing hydrophobic moieties as promising candidates for Alzheimer's disease therapy [62]. Mahalap- The nucleophilic substitution of 2,3-dichloro-1,4-naphthoquinone is a synthetic strategy for introducing nitrogen, oxygen, carbon, sulfur, and selenium nucleophiles at C2 and C3 positions [61].…”

Section: Chemical Modification Of Nqs Structures With Nitrogen Groupsmentioning

confidence: 99%

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The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

et al. 2023

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Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones are secondary metabolites found in plants and are used in traditional medicine to treat diverse human diseases. Considering this, the synthesis of naphthoquinone derivatives has been explored to contain compounds with potential biological activity. It has been reported that the chemical modification of naphthoquinones improves their pharmacological properties by introducing amines, amino acids, furan, pyran, pyrazole, triazole, indole, among other chemical groups. In this systematic review, we summarized the preparation of nitrogen naphthoquinones derivatives and discussed their biological effect associated with redox properties and other mechanisms. Preclinical evaluation of antibacterial and/or antitumoral naphthoquinones derivatives is included because cancer is a worldwide health problem, and there is a lack of effective drugs against multidrug-resistant bacteria. The information presented herein indicates that naphthoquinone derivatives could be considered for further studies to provide drugs efficient in treating cancer and multidrug-resistant bacteria.

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Section: Chemical Modification Of Nqs Structures With Nitrogen Groupsmentioning

confidence: 99%

Section: Chemical Modification Of Nqs Structures With Nitrogen Groupsmentioning

confidence: 99%

The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

et al. 2023

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“…2,3-Дихлор-1,4-нафтохинон (NQ, торговое название дихлон) (рис. 1а) является одним из важнейших производных 1,4-нафтохинона, и в современной химии используется как ключевой промежуточный продукт в синтезе новых 1,4-нафтохинонов, обладающих различными фармакологическими свойствами [15][16][17][18].…”

Section: Introductionunclassified

Voltammetric Determination of 1,4-Naphthoquinone Derivatives

2022

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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In this work, we have studied the physicochemical behaviors of oxidation-reduction of 2,3-dichloro-1,4-naphthoquinone (NQ) and 2-chloro-3-((4-hydroxyphenyl) amino)-1,4-naphthoquinone (NQ1) synthesized on the basis of NQ, on impregnated graphite electrode. The nature of the electrochemical processes was determined and the mechanism of oxidation-reduction of substances was assumed. The operating conditions for the voltammetric determination of compounds on an impregnated graphite electrode were selected, such as the supporting electrolyte – 0.1 M NaClO4 solution in 96% ethanol (pH=2 for NQ, pH=10 for NQ1), V=100 mV·s-1, as well as the potential and time of accumulation (Eacc +1 V; tacc 50 s for NQ and Eacc -1 V; tacc 30 s for NQ1). It is shown that the pH of the supporting electrolyte has a high influence on NQ and NQ1 analytical signal. For NQ, the current reaches its maximum value at pH = 2. For NQ1, the opposite effect of pH on the current intensity is observed: the maximum current value is reached at pH = 12. The linear dependence of the reduction peak current at a potential of 0.12 V on the concentration of NQ is observed in the range 2·10-5 – 8·10-4 mol·l-1 with the regression equation I=3.14C - 0.35 (R2=0.9992). For NQ1, the linear range of the calibration curve of the electro oxidation current at a potential of -0.58 V on the concentration is maintained in the range 1·10-6 – 8·10-4 mol·l-1 with regression equation I=45.74C +0.37 (R2=0.9992). The detection limit (LOD) for NQ, calculated according to the 3S criterion, is 7.2·10-6 mol·l-1, for NQ1 8·10-7 mol·l-1. The accuracy of the method of analyzed compounds quantitative determination in the substance was checked by the "spiked test" method.

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Dichlone

Chatterjee¹,

Chittiboyina²

2024

Encyclopedia of Toxicology

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Synthetic and Biological Utility of 2,3-Dichloro-1,4-Naphthoquinone: A Review

Cited by 4 publications

References 130 publications

The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

Voltammetric Determination of 1,4-Naphthoquinone Derivatives

Dichlone

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