Role of Antioxidants Derived from Herbal Medicines: Potential Anticancerous Agents

Ahmad, Qazi Zaid; Rаhmаn, Аziz Ur; Nafees, Huda; Zaki, Zainab

doi:10.1007/978-981-16-4935-6_3

Cited by 1 publication

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References 169 publications

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“…Growth hormone deficiency in children and adults: Ghrelin and GH-IGF-1 axis relationships (GHD). Hytосhemiсаls of plants, such as phenols and flavonoids, seem to act in various ways to protect health [7]. In malnourished conditions, the activities of mitochondrial enzymes in the muscle fibres, which are significantly affected by the mitochondrial state, determine the metabolic capacity of skeletal muscles [8].…”

Section: Introductionmentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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Background: Nutritional shortages and acute malnutrition are caused by insufficient protein and calorie consumption. With severe short-and longterm morbidity and death, malnutrition is a serious public health concern. In cachectic situations, the peptide ghrelin level raises making people more hungry. Life protein deficiency changes crucial neurotransmitters, including serotonin, and the brain redox status that underlies neurobehavioral expression.Aim: This study aimed to determine whether the combination of Curcuma xanthorrhixa Roxb. and iron supplementation regulates serotonin and ghrelin expression. Methods: This study employed a true experimental posttest-only control group design. The study subjects were 25 male Wistar rats divided into five groups. Curcuma xanthorrhiza Roxb. Rhizome extract at 80 mg/kg BW/day and elemental iron at 0.054 mg/kg BW/day were administered orally for 14 days after malnutrition induction. The differences between the groups before and after the completion of study interventions were calculated. Results: Curcuma xanthorrhiza Roxb. rhizome extract groups with elemental iron and combinations did not differ significantly in ghrelin levels. (p=0.88, Kruskal-Wallis H test). Serotonin levels did not differ between the groups (p=0.84, Kruskal-Wallis H test). Conclusion: Elemental iron, Curcuma xanthorrhiza Roxb., and the combination treatment did not alter the expression of serotonin or ghrelin. More studies are required on the effects of Curcuma xanthorrhiza Roxb., elemental iron, and a combination of these factors to reverse the effects of malnutrition. Further research is required to utilize higher macronutrient diets and supplements after malnutrition induction.

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Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Role of Antioxidants Derived from Herbal Medicines: Potential Anticancerous Agents

Cited by 1 publication

References 169 publications

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