Bioinspired Self-Adhesive Lubricated Coating for the Surface Functionalization of Implanted Biomedical Devices

Zhao, Yanlong; Wang, Haimang; Zhao, Weiwei; Luo, Jing; Zhao, Xin; Zhang, Hongyu

doi:10.1021/acs.langmuir.2c02250

Cited by 4 publications

(3 citation statements)

References 33 publications

(43 reference statements)

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“…In a previous study, we proposed the synthesis of a copolymer, namely, PASGA by the carbodiimide coupling reaction of gallic acid and a polymer (PAPSBMA), which was synthesized by free radical polymerization of N -(3-aminopropyl) methacrylamide hydrochloride and sulfobetaine methacrylate . This PASGA copolymer, equipped with self-adhesive and zwitterionic groups, demonstrated superior lubrication and stability both macro- and microscopically.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Self-Adhesive Multifunctional Lubricated Coating for Biomedical Implant Applications

Jia,

Zhao,

Zhang

2024

ACS Appl. Bio Mater.

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In the realm of clinical applications, the concern surrounding biomedical device-related infections (BDI) is paramount. To mitigate the risk associated with BDI, enhancing surface characteristics such as lubrication and antibacterial efficacy is considered as a strategic approach. This study delineated the synthesis of a multifunctional copolymer, embodying self-adhesive, lubricating, and antibacterial properties, achieved through free radical polymerization and a carbodiimide coupling reaction. The copolymer was adeptly modified on the surface of stainless steel 316L (SS316L) substrates by employing a facile dip-coating technique. Comprehensive characterizations were performed by using an array of analytical techniques including Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, optical interferometry, scanning electron microscopy, and atomic force microscopy. Nanoscale tribological assessments revealed a notable reduction in the value of the friction coefficient of the copolymercoated SS316L substrates compared to bare SS316L samples. The coating demonstrated exceptional resistance to protein adsorption, as evidenced in protein contamination models employing bovine serum albumin and fibrinogen. The bactericidal efficacy of the copolymer-modified surfaces was significantly improved against pathogenic strains such as Staphylococcus aureus and Escherichia coli. Additionally, in vitro evaluations of blood compatibility and cellular compatibility underscored the remarkable anticoagulant performance and biocompatibility. Collectively, these findings indicated that the developed copolymer coating represented a promising candidate, with its facile modification approach, for augmenting lubrication and antifouling properties in the field of biomedical implant applications.

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Section: Introductionmentioning

confidence: 99%

Bioinspired Self-Adhesive Multifunctional Lubricated Coating for Biomedical Implant Applications

Jia,

Zhao,

Zhang

2024

ACS Appl. Bio Mater.

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“…Although antibiotics and anticoagulants are effective against infection and thrombosis, there may be potential side effects such as fever, antibiotic resistance, and bleeding. − In contrast to systemic drug delivery that primarily provides a short-term effect, the surface modification strategy can provide a long-lasting effect and endow the surface with specific functions without altering the main properties of biomaterial, thus offering a promising option for addressing the clinical complications of biomedical devices. The zwitterionic polymer coatings, as one of the representative surface modification methods, have been widely investigated due to their excellent hemocompatibility and antifouling performances. − Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), as a typical zwitterionic polymer with repeated units that contain both positively and negatively charged groups, is able to strongly retain water and form a dense and stable hydration layer . Previous studies have demonstrated that the hydration layer formed by zwitterionic polymers can effectively prevent non-specific adhesion of proteins and bacteria, thereby avoiding the subsequent formation of thrombosis and biofilm .…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation

Zhao

Qian

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Endowing the implanted biomaterial with a wide range of functions, such as lubrication and antibacterial and anticoagulation properties, is essential for their safe clinical use. In the present study, based on the superlubrication mechanism of articular cartilage, a branched polyelectrolyte polymer (PEI-PMPC) was successfully synthesized based on tert-butyl hydroperoxide-initiated grafting polymerization and then applied to the biocompatible polyurethane (PU) surface. Specifically, the PU sheet was pretreated by polydopamine (PDA), and the PEI-PMPC polymer was grafted onto the PDAmodified PU surface by Schiff base reaction to generate a solid PDA/ PEI-PMPC coating. The unmodified and modified surfaces were characterized by Fourier transform infrared spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and surface zeta potential. To compare the lubrication, antibacterial behavior, and hemocompatibility, the relevant properties of the modified surfaces were evaluated by the tribological test, plate count method, surface morphology, hemolysis rate, activated partial thromboplastin time, and thrombin time. The experimental results demonstrated that the adhesion of bovine serum albumin, Escherichia coli, Staphylococcus aureus, platelets, and red blood cells was significantly decreased on the PEI-PMPC-modified PU surface compared with that of the unmodified PU surface. The multifunctional properties of the coating were attributed to the hydration layer formed by zwitterionic phosphorylcholine groups, and additionally, the cationic PEI served to kill the bacteria adhering to the surface. In summary, the bioinspired coating proposed in this study could potentially be used as a promising surface functionalization strategy for biomedical implants.

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“…As a silicone polymer with stable physical-chemical properties and good biocompatibility, polydimethylsiloxane (PDMS) has been widely applied in many biomedical applications (catheters, stents, cosmetic implants, etc. ). − However, the nonpolar silicon–oxygen chain and special self-helical molecular structure of silicone rubber materials make their surfaces have extremely low surface energy and thus show strong hydrophobicity. , Hydrophobic materials exhibit poor antiwear effects in water environments. , This may lead to greater frictional resistance when silicone rubber medical devices (such as interventional catheters) are squeezed and sheared in the soft tissues of the human body. This results in adverse symptoms in the medical process (such as tissue damage and ulcers). − In addition, the surface of hydrophobic medical catheters easily adsorbs small biomolecules (such as proteins and bacteria), and the surface of long-term used catheters is prone to form biofilms, which increases the risk of infection. − To alleviate patient discomfort caused by the use of interventional medical devices, glycerin and other lubricants are usually used in clinical practice to reduce the frictional resistance between these devices and soft tissues.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of PDMS Surface Coating for Ultra-Low Friction Characteristics

Chen,

Xu,

Tang

et al. 2023

Langmuir

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Polydimethylsiloxane (PDMS) has excellent physical–chemical properties and good biocompatibility. Thus, PDMS has been widely applied in biomedical applications. However, the low surface free energy and surface hydrophobicity of PDMS can easily lead to adverse symptoms, such as tissue damage and ulceration, during medical treatment. Therefore, the construction of a hydrophilic low-friction surface on the PDMS surface could be helpful for alleviating patient discomfort and would be of great significance for broadening the application of PDMS in the field of interventional medical catheters. Existing surface modification methods such as hydrogel coatings and chemical grafting suffer from several deficiencies including uncontrollable thickness, surface fragility, and low surface strength. In this study, a hydrophilic surface with ultra-low friction properties was prepared on the surface of PDMS by an ultraviolet light (UV) curing method. The monomer acrylamide (AM) was induced by a photoinitiator to form a coating on the surface of the silicone rubber by in situ polymerization. The surface roughness of the as-prepared coatings was regulated by adding different concentrations of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) to the monomer solution, and the coating properties were systematically characterized. The results indicated that the roughness and thickness of the as-prepared coatings decreased with increasing AMPS concentration and the as-prepared coatings had good hydrophilicity and low-friction properties. The Coefficient of Friction (CoF) was as low as 0.0075 in the deionized water solution, which was 99.7% lower than that of the unmodified PDMS surface. Moreover, the coating with a lower surface roughness exhibited better low-friction properties. The results reported herein provide new insight into the preparation of hydrophilic, low-friction coatings on polymer surfaces.

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Bioinspired Self-Adhesive Lubricated Coating for the Surface Functionalization of Implanted Biomedical Devices

Cited by 4 publications

References 33 publications

Bioinspired Self-Adhesive Multifunctional Lubricated Coating for Biomedical Implant Applications

Bioinspired Self-Adhesive Multifunctional Lubricated Coating for Biomedical Implant Applications

Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation

Preparation and Properties of PDMS Surface Coating for Ultra-Low Friction Characteristics

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