Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing

Abstract

Inspired by the coordinated multiple healing mechanism of the organism, a four‐armed benzaldehyde‐terminated polyethylene glycol and dodecyl‐modified chitosan hybrid hydrogel with vascular endothelial growth factor (VEGF) encapsulation are presented for efficient and versatile wound healing. The hybrid hydrogel is formed through the reversible Schiff base and possesses self‐healing capability. As the dodecyl tails can insert themselves into and be anchored onto the lipid bilayer of the cell membrane, the hybrid hydrogel has outstanding tissue adhesion, blood cell coagulation and hemostasis, anti‐infection, and cell recruitment functions. Moreover, by loading in and controllably releasing VEGF from the hybrid hydrogel, the processes of cell proliferation and tissue remodeling in the wound bed can be significantly improved. Based on an in vivo study of the multifunctional hybrid hydrogel, it is demonstrated that acute tissue injuries such as vessel bleeding and liver bleeding can be repaired immediately because of the outstanding adhesion and hemostasis features of the hydrogel. Moreover, the chronic wound‐healing process of an infectious full‐thickness skin defect model can also be significantly enhanced by promoting angiogenesis, collagen deposition, macrophage polarization, and granulation tissue formation. Thus, this multifunctional hybrid hydrogel is potentially valuable for clinical applications.

Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing

“…For wound dressing materials, hemostasis is a critical evaluation index as the excessive loss of blood from the trauma 2c,9k,20. As animal model, Sprague–Dawley (SD) male rat was used by cutting down part of the tail.…”

Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

“…[25,26] Additionally, hydrophobic interactions can induce spontaneous coacervation in water. [27] Herein, a hyperbranched polymer was synthesized based on Michael addition reaction of multi-vinyl monomers with amine. We can imagine that when the adhesive is in contact with water, the hydrophobic chain will aggregate and form coacervates quickly, thus repelling water molecules on the substrate surface.…”

“…However, the potential toxicity of cyanoacrylate and glutaraldehyde to the organism limits their medical use, while hemostatic bandage is unsuitable for treating deep wounds. [27] Owing to its flowable injectability, these HBPA hemostats can be readily delivered into the bleeding site in deep wounds through a syringe to realize rapid hemostasis. To impart the hemostatic function to our HBPA, we introduced long alkyl long chain (dodecylamine, decylamine, and octylamine) to this modularized structure to fabricate a hemostat (termed as HBPA-DDA, HBPA-DA, and HBPA-OA) ( Figure S11, Supporting Information), considering its recognized hemostasis and better biocompatibility.…”

Rapid and Large‐Scale Production of Multi‐Fluorescence Carbon Dots by a Magnetic Hyperthermia Method

“…Furthermore, the as‐prepared PCL/CDs nanofibrous membranes can be used in promoting wound healing owing to their good biocompatibility . In this work, we evaluated the wound healing behavior of PCL/Zn‐CDs nanofibrous scaffolds based on the reported Sprague–Dawley (SD) rat full‐thickness cutaneous defect model . The optical images of wound after treatment were shown in Figure e, and the wound areas decreased with healing time.…”