Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases

Shi, Yesi; Qian, Hongyan; Rao, Peishi; Mu, Dan; Liu, Yuan; Liu, Gang; Lin, Zhongning

doi:10.1016/j.apsb.2021.09.025

Cited by 15 publications

(17 citation statements)

References 110 publications

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“…The excellent antitumor therapeutic performance of MPD@DMV agents could be attributed to the delivery ability of these nanoparticles into tumor tissues, the thermal effect, and then secretion of self-antigens after laser irradiation as well as the adjuvant function from DMVs to strengthen the immune system. We anticipate that such MPD@DMV formulation would be a starting point for future studies focused on simultaneous bacteria-derived products and environmentally friendly materials in cancer therapeutics. , …”

Section: Discussionmentioning

confidence: 99%

Cloaking Mesoporous Polydopamine with Bacterial Membrane Vesicles to Amplify Local and Systemic Antitumor Immunity

et al. 2023

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As adjuvants or antigens, bacterial membranes have been widely used in recent antibacterial and antitumor research, but they are often injected multiple times to achieve therapeutic outcomes, with limitations in biosafety and clinical application. Herein, we leverage the biocompatibility and immune activation capacity of Salmonella strain VNP20009 to produce double-layered membrane vesicles (DMVs) for enhanced systemic safety and antitumor immunity. Considering the photothermal effect of polydopamine upon irradiation, VNP20009-derived DMVs are prepared to coat the surface of mesoporous polydopamine (MPD) nanoparticles, leading to the potential synergies between photothermal therapy mediated by MPD and immunotherapy magnified by DMVs. The single dose of MPD@DMV can passively target tumors and activate the immune system with upregulated T cell infiltration and secretion levels of pro-inflammatory factors as well as antitumor related cytokines. All of these promoted immune responses result in malignant melanoma tumor regression and extended survival time on local or distant tumor-bearing mouse models. Importantly, we further explore the advantages of intravenous injection of the MPD@DMV agent compared with its intratumoral injection, and the former demonstrates better long-term immune effects on animal bodies. Overall, this formulation design brings broader prospects for the autologous vaccine adjuvant by bacterial membrane vesicles in cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Cloaking Mesoporous Polydopamine with Bacterial Membrane Vesicles to Amplify Local and Systemic Antitumor Immunity

et al. 2023

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“…In recent years, endogenous materials such as biomembrane-coated vectors and extracellular vesicles (EVs) have received more and more attention. Compared with traditional nanomaterials, biomembrane-coated NDDSs can mimic many natural characteristics of their cells of origin 214 , 215 , 216 . The current biomembrane-coated nanomaterials in research mainly include red blood cell (RBC) membrane 217 , platelet membrane 218 , immune cell membrane 219 , tumor cell membrane 220 , and hybrid cell membrane 221 .…”

Section: Carrier-based Smart Drug Deliverymentioning

confidence: 99%

Smart drug delivery systems for precise cancer therapy

Wang

et al. 2022

Acta Pharmaceutica Sinica B

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“…In the treatment of Gram-positive bacterial infections, cell membrane-coated nanoparticles are used as a detoxification platform, because the cell membrane-derived nanosponge can absorb toxins, diverting them away from the cellular target . Different from the biodetoxification application in Gram-positive bacterial infection, the therapeutic potential of cell membrane-coated nanoparticles relies on the retention of pattern recognition receptors identical to the source cell membrane for Gram-negative bacterial infections . These antigenic exterior receptors neutralize the concentration of toxins of Gram-negative bacteria, inhibiting activation of toxin signaling and conduction of downstream cascades.…”

Section: Mechanisms Of Interaction Between Cell Membrane-coated Nanop...mentioning

confidence: 99%

“…As for viral infections, pathogens share a common initiating pathological feature in the attachment of the virus to the cellular surface. Thus, the specific binding affinity highlighted the potential of cell membrane-coated nanoparticles to act as nanodecoys by inheriting cell surface antigens for viral binding . In addition, the rapid development of biomimetic cell membrane-coated nanoparticles in bacterial and viral infections inspired their applications in fungal infection management, which is usually neglected by the public but is a serious medical issue.…”

Section: Mechanisms Of Interaction Between Cell Membrane-coated Nanop...mentioning

confidence: 99%

“…12 Different from the biodetoxification application in Gram-positive bacterial infection, the therapeutic potential of cell membrane-coated nanoparticles relies on the retention of pattern recognition receptors identical to the source cell membrane for Gram-negative bacterial infections. 20 These antigenic exterior receptors neutralize the concentration of toxins of Gram-negative bacteria, inhibiting activation of toxin signaling and conduction of downstream cascades. As for viral infections, pathogens share a common initiating pathological feature in the attachment of the virus to the cellular surface.…”

Section: Mechanisms Of Interaction Between Cell Membrane-coated Nanop...mentioning

confidence: 99%

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Cell Membrane-Coated Nanoparticles for Management of Infectious Diseases: A Review

Sun

Yang

et al. 2022

Ind. Eng. Chem. Res.

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Infectious diseases have emerged as leading threats to global healthcare, such as bacterial and viral infections. Major challenges in combating these infectious diseases are the emergence of adverse effects during the long-term use of anti-infectious drugs and the increasing prevalence of drug resistance. Cell membrane-coated nanoparticles have great potential in the prevention and therapy of infectious diseases. This promising therapeutic strategy is to employ cell membrane-based nanoparticles as a decoy to detain pathogenic microbes, a drug delivery platform, and an immunogenicity complex. Herein, the accelerating progression of biomimetic cell membrane-coated nanoparticles for the management of various infectious diseases is highlighted. We also discuss the challenges and the further application of cell membrane-coated nanoparticles in the view of clinical translation for combating infectious diseases. With a better understanding of the bioinspired camouflaged strategy, we anticipate that the use of cell membrane-coated nanoparticles will continue to grow and promote their applications in infectious diseases.

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Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases

Cited by 15 publications

References 110 publications

Cloaking Mesoporous Polydopamine with Bacterial Membrane Vesicles to Amplify Local and Systemic Antitumor Immunity

Cloaking Mesoporous Polydopamine with Bacterial Membrane Vesicles to Amplify Local and Systemic Antitumor Immunity

Smart drug delivery systems for precise cancer therapy

Cell Membrane-Coated Nanoparticles for Management of Infectious Diseases: A Review

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