Cell Membrane-Coated Nanoparticles for Management of Infectious Diseases: A Review

Abstract

Infectious diseases have emerged as leading threats to global healthcare, such as bacterial and viral infections. Major challenges in combating these infectious diseases are the emergence of adverse effects during the long-term use of anti-infectious drugs and the increasing prevalence of drug resistance. Cell membrane-coated nanoparticles have great potential in the prevention and therapy of infectious diseases. This promising therapeutic strategy is to employ cell membrane-based nanoparticles as a decoy to detain pathogenic microbes, a drug delivery platform, and an immunogenicity complex. Herein, the accelerating progression of biomimetic cell membrane-coated nanoparticles for the management of various infectious diseases is highlighted. We also discuss the challenges and the further application of cell membrane-coated nanoparticles in the view of clinical translation for combating infectious diseases. With a better understanding of the bioinspired camouflaged strategy, we anticipate that the use of cell membrane-coated nanoparticles will continue to grow and promote their applications in infectious diseases.

Engineering Cell Membranes: From Extraction Strategies to Emerging Biosensing Applications

“…Apart from the several innovative and commonly used preparation methods mentioned above, other novel methods for the encapsulation of nanoparticles into cell membranes have been reported. Freeze–thaw/sonication, extrusion/sonication and stirring, extrusion/electroporation, and in situ packaging methods have also been successfully applied in coating cell membranes on the surface of nanomaterials. ,, Collectively, the extracted cell membrane can be employed in analyzing various substances directly in the form of vesicles or to prepare cell membrane-coated nanoparticles using membrane coating technology for bioanalysis.…”

T Cell and Natural Killer Cell Membrane-Camouflaged Nanoparticles for Cancer and Viral Therapies

“…Cell membrane-coated NPs possess prospects in antiviral therapy. 80 Despite recent advancements in treatment, HIV type-1 infection is still fatal. Eliminating the virus is challenging because of the presence of residual viruses that evade therapy.…”

“…The utilization of combination antiretroviral therapy is wide-ranging, but the emergence of resistance and the difficulties associated with long-term medication pose significant challenges to traditional therapies. Cell membrane-coated NPs possess prospects in antiviral therapy …”

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

“…The liposomes loaded with chloroquinoline effectively transferred the drugs, inhibiting parasite growth. Furthermore, combination therapy encapsulates antiparasitic medications with immune modulators, improving treatment outcomes and enhancing bioavailability and therapeutic value [145]. Accordingly, Moles and his research group [85] confirmed immuno-PEG-liposomes for targeted drug delivery in a murine malaria model, efficiently encapsulating amphiphilic drugs like chloroquine and primaquine using a pH gradient.…”