Smart drug delivery systems for precise cancer therapy

Wang, Xiaoyou; Li, Chong; Wang, Yiguang; Chen, Huabing; Zhang, Xinxin; Luo, Cong; Zhou, Wenhu; Li, Lili; Teng, Lesheng; Yu, Haijun; Wang, Jiancheng

doi:10.1016/j.apsb.2022.08.013

Cited by 73 publications

(38 citation statements)

References 242 publications

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“…Nanoscale drug delivery systems (NDDS) play important roles in hydrophobic drug delivery [ 1 , 2 ]; therefore, they have been extensively studied during the last several years [ 3 , 4 ]. Many nanomaterials, especially amphiphilic block copolymers, are utilized as nanocarriers to load hydrophobic drugs via physical entrapment [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers

et al. 2023

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The therapeutic efficacy of nanoscale drug delivery systems is related to particle size, zeta potential, morphology, and other physicochemical properties. The structure and composition of nanocarriers may affect their physicochemical properties. To systematically evaluate these characteristics, three analogues, namely polyethylene glycol (PEG), PEG-conjugated octadecylamine (PEG-C18), and tri(ethylene glycol) (TEG), were explored as nanocarriers to entrap celastrol (CSL) via the injection-combined dialysis method. CSL nanoparticles were successfully prepared as orange milky solutions, which revealed a similar particle size of approximately 120 nm, with narrow distribution and a negative zeta potential of −20 mV. All these CSL nanoparticles exhibited good storage stability and media stability but presented different drug-loading capacities (DLCs), release profiles, cytotoxicity, and hemolytic activity. For DLCs, PEG-C18/CSL exhibited better CSL entrapment capacity. Regarding the release profiles, TEG/CSL showed the lowest release rate, PEG-C18/CSL presented a moderate release rate, and PEG/CSL exhibited a relatively fast release rate. Based on the different release rates, PEG-C18/CSL and TEG/CSL showed higher degrees of cytotoxicity than PEG/CSL. Furthermore, TEG/CSL showed the lowest membrane toxicity, and its hemolytic rate was below 20%. These results suggest that the structural effects of nanocarriers can affect the interactions between nanocarriers and drugs, resulting in different release profiles and antitumor activity.

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Section: Introductionmentioning

confidence: 99%

A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers

et al. 2023

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“…Instrumental to understanding and harnessing the functioning of biological systems at their most fundamental levels is the intracellular delivery of molecules (e.g., small biomolecules, nucleic acids, proteins and synthetic nanomaterials) that do not passively diffuse across the cell membrane under normal circumstances [ 1 , 2 , 3 ]. To this end, a plethora of intracellular delivery methods has been developed, which can be categorized as either carrier-mediated [ 4 , 5 , 6 , 7 ] or membrane-disruption-mediated methods [ 8 ]. Though carrier-mediated delivery shows great therapeutic potential, particularly for in vivo applications, interest in physical membrane-disruption-mediated delivery techniques has risen over the past few years, especially for in vitro or ex vivo manipulation of cells.…”

Section: Introductionmentioning

confidence: 99%

Response Surface Methodology to Efficiently Optimize Intracellular Delivery by Photoporation

Goemaere

Punj

Harizaj

et al. 2023

IJMS

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Photoporation is an up-and-coming technology for the gentle and efficient transfection of cells. Inherent to the application of photoporation is the optimization of several process parameters, such as laser fluence and sensitizing particle concentration, which is typically done one factor at a time (OFAT). However, this approach is tedious and runs the risk of missing a global optimum. Therefore, in this study, we explored whether response surface methodology (RSM) would allow for more efficient optimization of the photoporation procedure. As a case study, FITC-dextran molecules of 500 kDa were delivered to RAW264.7 mouse macrophage-like cells, making use of polydopamine nanoparticles (PDNPs) as photoporation sensitizers. Parameters that were varied to obtain an optimal delivery yield were PDNP size, PDNP concentration and laser fluence. Two established RSM designs were compared: the central composite design and the Box-Behnken design. Model fitting was followed by statistical assessment, validation, and response surface analysis. Both designs successfully identified a delivery yield optimum five- to eight-fold more efficiently than when using OFAT methodology while revealing a strong dependence on PDNP size within the design space. In conclusion, RSM proves to be a valuable approach to efficiently optimize photoporation conditions for a particular cell type.

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Section: Introductionmentioning

confidence: 99%

“…The drug delivery systems (DDSs) composed of different functional blocks are capable of increasing the water solubility, bioavailability, and stability, as well as reducing the toxic side effects of the model drugs, which is an effective assistant for targeted drug delivery. [23][24][25][26] Supramolecular nanoparticles that are effective in improving the undesirable properties of drugs are a class of drug carriers. [27] Since supramolecular nanocarriers are assemblies formed by non-covalent interactions between host and guest, such as hydrogen bonds, van der Waals forces, hydrophobic interactions, electrostatic interactions, etc., they can easily respond to external stimuli such as temperature, pH, light, magnetism, enzymes, redox, or even their combinations, and further release the cargo loading in the chamber of nanocarriers.…”

Section: Introductionmentioning

confidence: 99%

A Supramolecular Nanovehicle Featuring a pH/Enzyme Co‐Response for Targeted Delivery of the Antitumor Compound

et al. 2023

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Triptolide (TPL) has gained much attention as an antitumor compound with potential applications. However, TPL suffers from low bioavailability, severe toxic side effects, and limited targeted uptake by tumor cells, thus restricting the conversion of its clinical application. Here, a supramolecular nanovehicle, named TSCD/MCC NPs, featuring pH/AChE co-response was designed and prepared for loading, delivery, and targeted release of TPL. The cumulative release rate of TPL from TPL@TSCD/MCC NPs reached ~90 % within 60 h at pH 5.0 and AChE co-stimulation. Bhaskar model is used to study TPL release procedure. In cell experiments, TPL@TSCD/MCC NPs showed high toxicity to the four tumor cells lines A549, HL-60, MCF-7, and SW480, and favorable biosafety to normal cells BEAS-2B. Furthermore, TPL@TSCD/MCC NPs containing relatively small amounts of TPL presented similar apoptosis rates to those of intrinsic TPL. We anticipate that TPL@TSCD/MCC NPs may facilitate the conversion of TPL into clinical applications through further studies.

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Smart drug delivery systems for precise cancer therapy

Cited by 73 publications

References 242 publications

A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers

A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers

Response Surface Methodology to Efficiently Optimize Intracellular Delivery by Photoporation

A Supramolecular Nanovehicle Featuring a pH/Enzyme Co‐Response for Targeted Delivery of the Antitumor Compound

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