Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry

Abstract

This review paper describes novel biointerfaces for nanobiodevices. Biocompatible and nonbiofouling surfaces are designed largely based on cell membrane structure, and the preparation and functioning of the bioinspired interface are evaluated and compared between living and artificial systems. A molecular assembly of polymers with a phospholipid polar group has been developed as the platform of the interface. At the surface, protein adsorption is effectively reduced and the subsequent bioreactions are suppressed. Through this platform, biomolecules with a high affinity to the specific molecules are introduced under mild conditions. The activity of the biomolecules is retained even after immobilization. This bioinspired interface is adapted to construct bionanodevices, that is, microfluidic chips and nanoparticles for capturing target molecules and cells. The interface functions well and has a very high efficiency for biorecognition. This bioinspired interface is a promising universal platform that integrates various fields of science and has useful applications.

Cytotoxicity assays of new artificial tears containing 2-methacryloyloxyethyl phosphorylcholine polymer for ocular surface cells

“…The 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer is an antiadhesive, antithrombogenetic, and highly hydrating multifunction agent [8][9][10][11]. A zwitterionic phosphorylcholine group in the MPC complex mirrors one of the major phospholipid polar groups on the outer surface of the cell membrane.…”

Photoinduced atom transfer radical polymerization in a polar solvent to synthesize a water-soluble poly(2-methacryloyloxyethyl phosphorylcholine) and its block-type copolymers

“…2-Methacryloyloxyethyl phosphorylcholine (MPC) is usually employed in the preparation of phospholipid polymers as it shows excellent polymerization ability via radical polymerization and is easily copolymerizable with other monomers [21]. MPC polymers express high cytocompatibility and the ability to resist protein adsorption and cell adhesion [19,20,22]. Various MPC polymers with specialized functionality have been prepared, e.g., copolymers with hydrophobic moiety for use as drug solubilizers [23], antibody-conjugating copolymers for surface modifications to improve the sensitivity of immunoassays [24], and reversible cross-linkable polymer for formations of cell encapsulating hydrogels [25].…”

PEGylated polymers for medicine: from conjugation to self-assembled systems

“…PolyMPC is becoming recognized as perhaps the most biocompatible of synthetic polymers, naturally leading to various successful applications including, for example, contact lenses, stents, and various medical devices and implants. [47][48][49][50][51][52][53] Advances in controlled free radical polymerization, especially copper-catalyzed atom transfer radical polymerization (ATRP), are enabling the preparation of novel polyMPC derivatives appropriate for conjugation to therapeutic proteins (Fig. 3).…”