Biogenic synthesis of gold nanoparticles mediated by Spondias dulcis (Anacardiaceae) peel extract and its cytotoxic activity in human breast cancer cell

Pechyen, Chiravoot; Ponsanti, Khanittha; Tangnorawich, Benchamaporn; Ngernyuang, Nipaporn

doi:10.1016/j.toxrep.2022.04.031

Cited by 21 publications

(10 citation statements)

References 64 publications

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“…This implies oxidative cell damage via ROS production. The outcomes of this experiment were in line with the past experimental results and thus emphasis on the benefits of green synthesis AUNPs encouraged DNA oxidative destruction, indicating the AUNPs mediated genotoxicity, resulting from the ROS-induced cytotoxicity [ 74 ].…”

Section: Gold Nanoparticles For Combating Cancersupporting

confidence: 86%

“…This led to a paradigm shift in AUNPs production. Pechyen et al, prepared AUNPs of Anacardiaceae peel extract using an uncomplicated photosynthesis procedure [ 74 ]. Anacardiaceae is a common tropical tree found in tropical, subtropical, and temperate climate zones.…”

Section: Gold Nanoparticles For Combating Cancermentioning

confidence: 99%

“…Various concentrations of AC-AUNPs were subjected to the assay. Results indicated the better cytotoxic action of prepared AC-AUNPs as compared to control and plain drug-loaded solution and in a dose- time dependant manner and this activity was highly prominent after 72 h of treatment [ 74 ]. This superior cytotoxic action of AC-AUNPs is attributed to the anomalies occurring at the metabolic stage and due to the prominent rate of proliferation that leads to enhanced cellular uptake of the nanoparticles [ 95 ].…”

Section: Gold Nanoparticles For Combating Cancermentioning

confidence: 99%

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Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Kesharwani

Liang

et al. 2023

Mol Cancer

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Cancer is a grievous disease whose treatment requires a more efficient, non-invasive therapy, associated with minimal side effects. Gold nanoparticles possessing greatly impressive optical properties have been a forerunner in bioengineered cancer therapy. This theranostic system has gained immense popularity and finds its application in the field of molecular detection, biological imaging, cancer cell targeting, etc. The photothermal property of nanoparticles, especially of gold nanorods, causes absorption of the light incident by the light source, and transforms it into heat, resulting in tumor cell destruction. This review describes the different optical features of gold nanoparticles and summarizes the advance research done for the application of gold nanoparticles and precisely gold nanorods for combating various cancers including breast, lung, colon, oral, prostate, and pancreatic cancer.

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Section: Gold Nanoparticles For Combating Cancersupporting

confidence: 86%

Section: Gold Nanoparticles For Combating Cancermentioning

confidence: 99%

Section: Gold Nanoparticles For Combating Cancermentioning

confidence: 99%

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Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Kesharwani

Liang

et al. 2023

Mol Cancer

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“…Five cancers which have recently documented applications in a research context are breast, colon, lung, prostate, and pancreatic cancers [ 36 ]. The MCF-7 breast cancer cell line treated with GNPs conjugated with extract from the Anacardiaceae showed greater dose-dependent cytotoxicity compared to control [ 99 ]. Another study targeted GNPs to breast cancer cell lines using CD44 as a ligand conjugate and found high cancer-cell-specific accumulation and reduced tumor growth in vivo [ 100 ].…”

Section: Gnp Applications In Cancer Nanotherapeuticsmentioning

confidence: 99%

Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives

Lansangan,

Khoobchandani,

Jain

et al. 2024

Materials

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Glioblastoma multiforme (GBM) is a glioma and the most aggressive type of brain tumor with a dismal average survival time, despite the standard of care. One promising alternative therapy is boron neutron capture therapy (BNCT), which is a noninvasive therapy for treating locally invasive malignant tumors, such as glioma. BNCT involves boron-10 isotope capturing neutrons to form boron-11, which then releases radiation directly into tumor cells with minimal damage to healthy tissues. This therapy lacks clinically approved targeted blood–brain-barrier-permeating delivery vehicles for the central nervous system (CNS) entry of therapeutic boron-10. Gold nanoparticles (GNPs) are selective and effective drug-delivery vehicles because of their desirable properties, facile synthesis, and biocompatibility. This review discusses biomedical/therapeutic applications of GNPs as a drug delivery vehicle, with an emphasis on their potential for carrying therapeutic drugs, imaging agents, and GBM-targeting antibodies/peptides for treating glioma. The constraints of GNP therapeutic efficacy and biosafety are discussed.

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“…Plant extracts have gained attention as reducing agents for AuNP synthesis due to their low toxicity, eco-friendliness, and simplicity of production [4,9]. Various plants, such as Anacardium occidentale [10], Spondias dulcis [11], and Pistacia chinensis [12], have been reported to be effective in reducing gold ions into differently shaped and sized nanoparticles. Nanotechnology has enabled the development of modern techniques for nanoscale copper generation over the past decade [13].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold and Copper Nanoparticles by Lannea discolor: Characterization and Antibacterial Activity

Rambau,

Masevhe,

Samie

2024

Inorganics

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Green synthesis using plant extracts has emerged as an eco-friendly, clean, and viable alternative to chemical and physical approaches. Herein, the leaf, stem, and root extracts of Lannea discolor were utilized as a reducing and stabilizing agent in synthesizing gold (AuNPs) and copper (CuNPs) nanoparticles. The formation of AuNPs and CuNPs, confirmed by their color change, was characterized by UV-Vis spectroscopy (UV-Vis), scanning electron microscopy analysis, and energy-dispersive X-ray (SEM-EDX), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR), coupled with minimum inhibitory concentration (MIC) antibacterial assays. Gold nanoflowers (AuNFs), NPs, and CuNPs peaked at wavelengths of 316, 544, and 564 nm, respectively. TEM showed unexpected nanoflowers (30–97 nm) in the leaf extracts and spherical NPs (10–33 nm; 9.3–37.5) from stem and root extracts, while spherical CuNPs (20–104 nm) were observed from all the extracts. EDX confirmed the presence of metal salts, and FTIR revealed stable capping agents. AuNPs and NFs from L. discolor extracts showed appreciable antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Klebsiella pneumoniae (ATCC 700603), and Bacillus subtilis (ATCC 6633) when compared to the plant extracts. At the same time, none was observed from the CuNPs. These AuNPs and CuNPs are particularly appealing in various biomedical and conductivity manufacturing applications due to their shapes and sizes and economical and environmentally friendly production. To our knowledge, this is the first study of the synthesis of gold and copper nanoparticles from L. discolor.

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Biogenic synthesis of gold nanoparticles mediated by Spondias dulcis (Anacardiaceae) peel extract and its cytotoxic activity in human breast cancer cell

Cited by 21 publications

References 64 publications

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives

Green Synthesis of Gold and Copper Nanoparticles by Lannea discolor: Characterization and Antibacterial Activity

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