Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration

Tang, Daniel; Tare, Rahul S.; Yang, Liang; Williams, David; Ou, Keng Liang

doi:10.1016/j.biomaterials.2016.01.024

Cited by 499 publications

(321 citation statements)

References 128 publications

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“…Biocompatibility refers to the performance of non-biological materials implanted in the body to cause autologous biological tissue reactions, which is related to the safety of the stent during clinical use [1]. Good biocompatibility requires that the scaffold material has good surface physicochemical properties to ensure normal adhesion and growth of the cells; the scaffold does not cause inflammatory reaction, any immunogenicity and cytotoxicity, and the degradation rate should be related to tissue growth.…”

Section: Biocompatibilitymentioning

confidence: 99%

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Application of 3D printing technology in bone tissue engineering

Wang

Wei

et al. 2018

Bio-des. Manuf.

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Section: Biocompatibilitymentioning

confidence: 99%

“…The bone tissue engineering principle is applied to construct a degradable porous bone scaffold, which is implanted into the human body after loading bone cells, growth factors, etc. [1]. These scaffolds can be decomposed and absorbed by bone cells to form new bone.…”

Section: Introductionmentioning

confidence: 99%

Application of 3D printing technology in bone tissue engineering

Wang

Wei

et al. 2018

Bio-des. Manuf.

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“…In addition, there is the possibility to print cells, DNA, and other bioactive components simultaneously with the printing of the polymer support matrix, layer by layer, and that would make the final product achieve a higher cellular density in the matrix than other techniques of cellular sedimentation that always happen after the polymeric scaffold is manufactured [62] [149] [150]. The first attempts were made in 2D by Odde et al (1999), who printed spinal cord cells on glass tray layered with culture medium using laser guided printing [151].…”

Section: D Printingmentioning

confidence: 99%

3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

Mota¹,

Silva²,

Lima³

et al. 2016

MSA

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Due to the high incidence of bone fractures in the population, it became necessary to produce scaffolds that are able to assist in tissue regeneration. It is necessary to find an appropriate balance between the mechanical and biological properties, in order to mimic the natural tissue, these properties are directly related to the architecture and their degree of porosity, as well as the size of their pores and their interconnectivity. In this perspective, the 3D printing stands out, where the structure is obtained layer by layer, according to a predetermined computational model which provides a greater control of architecture and scaffold geometry and overcomes, in this way, the limitations of traditional techniques of scaffolds manufacturing. In this way, the objective of this seminar is to present the state of the art of the polymer scaffolds produced by 3D printing and applied to bone tissue regeneration, highlighting the advantages and limitations of this process.

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“…The scaffold is a three-dimensional support suitable for the growth of a tissue or an organ, aiming to temporarily replace the functions of the extracellular matrix and to guide the proliferation and growth of cells [2]. Several studies showed that, without a proper template, the cells tend to arrange in a two-dimensional (2D) layer forming a flat structure with poor mechanical properties [3].…”

Section: Introductionmentioning

confidence: 99%

A Versatile Technique to Produce Porous Polymeric Scaffolds: The Thermally Induced Phase Separation (TIPS) Method

Conoscenti¹,

Carrubba²,

Brucato³

2017

Arch Chem Res

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Among the various scaffold fabrication techniques, thermally induced phase separation (TIPS) is one of the most versatile methods to produce porous polymeric scaffold and it has been largely used for its capability to produce highly porous and interconnected scaffolds. The scaffold architecture can be closely controlled by varying the process parameters, including polymer type and concentration, solvent/non-solvent ratio and thermal history. TIPS technique has been widely employed, also, to produce scaffolds with a hierarchical pore structure and composite polymeric matrix/inorganic filler foams.

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Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration

Cited by 499 publications

References 128 publications

Application of 3D printing technology in bone tissue engineering

Application of 3D printing technology in bone tissue engineering

3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

A Versatile Technique to Produce Porous Polymeric Scaffolds: The Thermally Induced Phase Separation (TIPS) Method

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