Bioengineered zinc oxide nanoparticles: Chemical, green, biological fabrication methods and its potential biomedical applications

Dutta, Gouranga; Sugumaran, Abimanyu

doi:10.1016/j.jddst.2021.102853

Cited by 23 publications

(15 citation statements)

References 189 publications

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“…The presence of high amounts of phytochemical compounds in plant extracts has been linked to their potential efficacy in the synthesis of ZnO NPs [21]. Different phytochemical compounds, such as tannins, terpenoids, phenolic compounds, methylxanthines, saponins and alkaloids, were reported as excellent zinc precursor reducers [22]. A mechanistic pathway was reported in several previous studies based on the phytochemical components of the utilized plant extract for the successful syntheis of ZnO NPs [23,24].…”

Section: Introductionmentioning

confidence: 97%

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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The high incidence of fungal resistance to antifungal drugs represents a global concern, contributing to high levels of morbidity and mortality, especially among immunocompromised patients. Moreover, conventional antifungal medications have poor therapeutic outcomes, as well as possible toxicities resulting from long-term administration. Accordingly, the aim of the present study was to investigate the antifungal effectiveness of biogenic zinc oxide nanoparticles (ZnO NPs) against multidrug-resistant candidal strains. Biogenic ZnO NPs were characterized using physicochemical methods, such as UV-vis spectroscopy, transmission electron microscopy (TEM), energy-dispersive X ray (EDX) spectroscopy, FTIR (Fourier transform infrared) spectroscopy and X-ray powder diffraction (XRD) analysis. UV spectral analysis revealed the formation of two absorption peaks at 367 and 506 nm, which preliminarily indicated the successful synthesis of ZnO NPs, whereas TEM analysis showed that ZnO NPs exhibited an average particle size of 22.84 nm. The EDX spectrum confirmed the successful synthesis of ZnO nanoparticles free of impurities. The FTIR spectrum of the biosynthesized ZnO NPs showed different absorption peaks at 3427.99, 1707.86, 1621.50, 1424.16, 1325.22, 1224.67, 1178.22, 1067.69, 861.22, 752.97 and 574.11 cm−1, corresponding to various functional groups. The average zeta potential value of the ZnO NPs was −7.45 mV. XRD analysis revealed the presence of six diffraction peaks at 2θ = 31.94, 34.66, 36.42, 56.42, 69.54 and 76.94°. The biogenic ZnO NPs (100µg/disk) exhibited potent antifungal activity against C. albicans, C. glabrata and C. tropicalis strains, with suppressive zone diameters of 24.18 ± 0.32, 20.17 ± 0.56 and 26.35 ± 0.16 mm, respectively. The minimal inhibitory concentration (MIC) of ZnO NPs against C. tropicalis strain was found to be 10 μg/mL, whereas the minimal fungicidal concentration (MFC) was found to be 20 μg/mL. Moreover, ZnO NPs revealed a potential synergistic efficiency with fluconazole, nystatin and clotrimazole antifungal drugs against C. albicans strain, whereas terbinafine, nystatin and itraconazole antifungal drugs showed a potential synergism with ZnO NPs against C. glabrata as a multidrug-resistant strain. In conclusion, pomegranate peel extract mediated green synthesis of ZnO NPs with potential physicochemical features and antimicrobial activity. The biosynthesized ZnO NPs could be utilized for formulation of novel drug combinations to boost the antifungal efficiency of commonly used antifungal agents.

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Section: Introductionmentioning

confidence: 97%

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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“…Zinc oxide nanoparticles (ZnO NPs) are one of the nanostructured materials of greatest interest due to their wide range of applications in pharmaceutical [ 1 ], electronic [ 2 ], medical [ 3 ], power generation [ 4 ], and environmental [ 5 ] fields, which is due to their multiple properties such as semiconductors, pyroelectrics, piezoelectrics, catalysts, optoelectronics [ 6 ], antimicrobial, and anticancer activity [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Sunlight Photocatalytic Performance of ZnO Nanoparticles Synthesized by Green Chemistry Using Different Botanical Extracts and Zinc Acetate as a Precursor

et al. 2021

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In this work, the assessment of Azadirachta indica, Tagetes erecta, Chrysanthemum morifolium, and Lentinula edodes extracts as catalysts for the green synthesis of zinc oxide nanoparticles (ZnO NPs) was performed. The photocatalytic properties of ZnO NPs were investigated by the photodegradation of methylene blue (MB) dye under sunlight irradiation. UV-visible (UV-Vis) spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Thermogravimetric (TGA), and Brunauer-Emmett-Teller analysis (BET) were used for the characterization of samples. The XRD results indicate that all synthesized nanoparticles have a hexagonal wurtzite crystalline structure, which was confirmed by TEM. Further, TEM analysis proved the formation of spherical and hemispherical nanoparticles of ZnO with a size in the range of 14–32 nm, which were found in aggregate shape; such a size was well below the size of the particles synthesized with no extract (~43 nm). ZnO NPs produced with Tagetes erecta and Lentinula edodes showed the best photocatalytic activity, matching with the maximum adsorbed MB molecules (45.41 and 58.73%, respectively). MB was completely degraded in 45 min using Tagetes erecta and 120 min using Lentinula edodes when subjected to solar irradiation.

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“…Additionally, they offer the potential to reduce reliance on various chemotherapeutic and antibiotic drugs. 13,14 Metal nanoparticles have been found to have practical applications in various elds, including optics, sensors, photocatalysis, semiconductors, pharmaceuticals, and biomedical applications. Owing to their unique attributes, such as a notable bandgap, optical characteristics, expansive surface area, and crystalline structures, that promote the scattering of subatomic particles, they exhibit adaptability for diverse applications.…”

Section: Introductionmentioning

confidence: 99%

“…Plants contain numerous genetic variants that produce phytomolecules and compounds (vitamins, proteins, coenzymes, avonoids, quinones, phenols, and carbohydrates) with functional molecules (-OH, -COOH, and -NH 2 ) that can interact with metal ions, shrinking them to the nanoscale, stabilizing them as nanoparticles, and overcoming the limitations of conventional chemical synthesis. 13,21 Our study offers a compelling analysis of ZnO and ZnO-Ag NP synthesis through an innovative green synthesis technique. We introduce the unexplored potential of Trichosanthes dioica seed extract as a biocatalyst for the preparation of metal nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Sustainable bioactivity enhancement of ZnO–Ag nanoparticles in antimicrobial, antibiofilm, lung cancer, and photocatalytic applications

Dutta,

Chinnaiyan,

Sugumaran

et al. 2023

RSC Adv.

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Bioengineered zinc oxide nanoparticles: Chemical, green, biological fabrication methods and its potential biomedical applications

Cited by 23 publications

References 189 publications

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Sunlight Photocatalytic Performance of ZnO Nanoparticles Synthesized by Green Chemistry Using Different Botanical Extracts and Zinc Acetate as a Precursor

Sustainable bioactivity enhancement of ZnO–Ag nanoparticles in antimicrobial, antibiofilm, lung cancer, and photocatalytic applications

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