Biodegradable zinc-containing mesoporous silica nanoparticles for cancer therapy

Chen, S.; Greasley, Sarah L.; Ong, Zhan Yuin; Naruphontjirakul, Parichart; Page, Sam J.; Hanna, John V.; Redpath, Andia N.; Tsigkou, Olga; Rankin, Sara M.; Ryan, Mary P.; Porter, Alexandra E.; Jones, Julian R.

doi:10.1016/j.mtadv.2020.100066

Cited by 35 publications

(23 citation statements)

References 37 publications

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“…Therefore, demonstrating apoptotic cancer cells in studies adds value to anticancer treatment approaches. 28,29 In this study, TUNEL stained cells in the cell fraction with and without apoptotic morphology were marked. Thus, it was aimed to determine the effectiveness of the VP-Afrt-CuS nanoparticles used in the MDA-MB-231 cancer cell line.…”

Section: And Fig S3 †)mentioning

confidence: 57%

Nanoparticles with PDT and PTT synergistic properties working with dual NIR-light source simultaneously

et al. 2021

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Section: And Fig S3 †)mentioning

confidence: 57%

Nanoparticles with PDT and PTT synergistic properties working with dual NIR-light source simultaneously

et al. 2021

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“…Thus, to avoid the formation of nanoceria, cerium was incorporated into MBGNPs through a postmodification method called template ion exchange (TIE). TIE and similar strategies have been widely used for the addition of metal ions to silica nanoparticles [ 20 , 37 , 47 , 48 ]. Cerium was successfully incorporated into MBGNPs without the formation of nanoceria, as evidenced by TEM images ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications

Kurtuldu

Kaňková

Beltrán

et al. 2021

Materials Today Bio

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Mesoporous bioactive glass nanoparticles (MBGNPs) are attracting significant attention as suitable materials for multifunctional biomedical applications. In this study, cerium was incorporated into MBGNPs using two different approaches. In the first approach, cerium was added to the glass system directly during the synthesis, while in the second approach, cerium was added to the as-synthesized MBGNPs via the template ion-exchange method. The influence of the method of synthesis on the physicochemical properties of nanoparticles was examined by SEM, TEM, XRD, FTIR, and N 2 adsorption-desorption analyses. The MBGNPs exhibited spheroidal morphology and disordered mesoporous structure. XRD analysis confirmed the amorphous nature of the nanoparticles. The chemical composition was determined by the acid digestion method using ICP-OES. The influence of the synthesis method on the specific surface area, mesoporosity, and solubility of synthesized nanoparticles in Tris/HCl (pH 7.4) and acetate (pH 4.5) buffer has also been studied. The obtained Ce containing MBGNPs were non-cytotoxic toward preosteoblast MC3T3-E1 cells in contact with nanoparticles in a concentration of up to 100 μg/mL. The anti-inflammatory effect of Ce containing MBGNPs was tested with lipopolysaccharides (LPS)-induced proinflammatory RAW 264.7 macrophage cells. Ce containing MBGNPs decreased the release of nitric oxide, indicating the anti-inflammatory response of macrophage cells. Ce containing MBGNPs also showed antibacterial activity against S. aureus and E. coli . The mentioned features of the obtained MBGNPs make them useful in a variety of biomedical applications, considering their biocompatibility, anti-inflammatory response, and enhanced antibacterial effect.

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“…Among the above mentioned ionic degradation products, Zn 2+ ions are attracting interest and zinc-based biomaterials have been increasingly investigated in the recent years 27,28 . Mesoporous silica nanoparticles doped by zinc were produced as a tunable biodegradable platform for target therapy of breast cancers 29 . Zinc has desirable properties for tissue regeneration and therapy, plays a crucial role in osteogenesis 30 , is involved in homeostasis, angiogenesis, and has antibacterial, antifungal and anticancer effects 31 .…”

Section: Accepted Articlementioning

confidence: 99%

Polymer (PCL) fibers with Zn‐doped mesoporous bioactive glass nanoparticles for tissue regeneration

Neščaková

Kaňková

Galusková

et al. 2021

Int J of Appl Glass Sci

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Composite fibrous membranes based on poly(ɛ-caprolactone) (PCL) and mesoporous bioactive glass nanoparticles (MBGNs) were fabricated by electrospinning. MBGNs and Zn-doped MBGNs prepared by microemulsion sol-gel method were successfully incorporated inside the polymeric fibers of 240 nm and 385 nm in diameter for undoped and Zn-doped PCL_MBGNs fibers, respectively. Thermal analysis showed that the concentration of MBGNs reached a maximum of around 21 wt% for Zn doped MBGNs. Both PCL_MBGNs and PCL_MBGNs_Zn composite membrane exhibited bioactivity after immersion in simulated body fluid (SBF). X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) showed the evolution of composite membranes, confirming the formation of hydroxyapatite (HAp). However, the degradation products of membranes did not affect the viability and proliferation of murine stromal cells (ST-2) and thus the new fiber structures represent a suitable environment for cell adhesion. Therefore, the incorporation of mesoporous glass nanoparticles doped with therapeutically active Zn 2+ ions inside the PCL fibers offers the possibility to create a multifunctional biomaterial suitable for drug delivery and tissue engineering.

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Biodegradable zinc-containing mesoporous silica nanoparticles for cancer therapy

Cited by 35 publications

References 37 publications

Nanoparticles with PDT and PTT synergistic properties working with dual NIR-light source simultaneously

Nanoparticles with PDT and PTT synergistic properties working with dual NIR-light source simultaneously

Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications

Polymer (PCL) fibers with Zn‐doped mesoporous bioactive glass nanoparticles for tissue regeneration

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