Biodegradable T2-phage-like Janus nanoparticles for actively-targeted and chemo-photothermal synergistic therapy

Gao, Pengcheng; Sun, Si; Wang, Yan; Wei, Yingying; Jiang, Yong

doi:10.1016/j.cej.2021.131284

Cited by 11 publications

(7 citation statements)

References 54 publications

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“…JNPs based on the morphology of each side can be divided into two categories: (1) Simple JNPs, such as spherical JNPs (Y. Xing, Zhou, et al, 2020), rod‐like JNPs (Paiva et al, 2020), or disk‐like JNPs (Yu et al, 2016), with the same shape and structure on both faces. (2) complex JNPs with distinct structures on each side and a wealth of assembled architectures, such as dumbbell‐like (M. He, Wang, et al, 2022), sphere‐cubic (Zhou et al, 2021), snowman‐like (Gao et al, 2022), satellite‐like (D. Zheng, 2021), and sphere‐star (Hernández Montoto et al, 2019) structures. JNPs are in the spotlight due to their outstanding features.…”

Section: Introductionmentioning

confidence: 99%

Magnetite‐based Janus nanoparticles, their synthesis and biomedical applications

Madadi

Khoee

2023

WIREs Nanomed Nanobiotechnol

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The advent of Janus nanoparticles has been a great breakthrough in the emerging field of nanomaterials. Janus nanoparticles refer to a single structure with two distinct chemical functions on either side. Owing to their asymmetric structures, they can be utilized in a variety of applications where monomorphic particles are insufficient. In the last decade, a wide variety of materials have been employed to fabricate Janus nanoparticles, and due to the great advantages of magnetite (Iron‐oxide) NPs, they have been considered as one of the best candidates. With the main benefit of magnetic controlling, magnetite Janus nanoparticles fulfill great promises, especially in biomedical areas such as bioimaging, cancer therapies, theranostics, and biosensing. The intrinsic characteristics of magnetite Janus nanoparticles (MJNPs) even hold great potential in magnetite Janus forms of micro‐/nanomotors. Despite the great interest and potential in magnetic Janus NPs, the need for a comprehensive review on MJNPs with a concentration on magnetite NPs has been overlooked. Herein, we present recent advancements in the magnetite‐based Janus nanoparticles in the flourishing field of biomedicine. First, the synthesis and fabrication methods of Janus nanoparticles are discussed. Then we will delve into their intriguing biomedical applications, with a separate section for magnetite Janus micro‐/nanomotors in biomedicine. And finally, the challenges and future outlook are provided.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vitro Nanoparticle‐Based Sensing

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Section: Introductionmentioning

confidence: 99%

Magnetite‐based Janus nanoparticles, their synthesis and biomedical applications

Madadi

Khoee

2023

WIREs Nanomed Nanobiotechnol

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“…It is worth noting that different structures of Janus particles can lead to unique physicochemical and functional properties [ 35 ]. For example, an inorganic-polymer hybrid can be used to improve the surface functionalization, biocompatibility, and stability of Janus particles [ 36 , 37 ]. Further, Janus particles composed of purely inorganic materials, such as inorganic-inorganic complexes, are promising candidates for biomedical applications as their region-specific functionalization makes them an ideal tool for bioimaging, in vivo diagnostics, delivery, and treatment [ 38 , 39 , 40 ].…”

Section: Overview Of Janus Particlesmentioning

confidence: 99%

Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications

Tan¹,

Danquah

Jeevanandam

et al. 2023

Pharmaceutics

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Janus particles have emerged as a novel and smart material that could improve pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two distinct compartments that differ in functionality, physicochemical properties, and morphological characteristics, among other conventional particles. Recently, Janus particles have attracted considerable attention as effective particulate drug delivery systems as they can accommodate two opposing pharmaceutical agents that can be engineered at the molecular level to achieve better target affinity, lower drug dosage to achieve a therapeutic effect, and controlled drug release with improved pharmacokinetics and pharmacodynamics. This article discusses the development of Janus particles for tailored and improved delivery of pharmaceutical agents for diabetes treatment and antimicrobial applications. It provides an account of advances in the synthesis of Janus particles from various materials using different approaches. It appraises Janus particles as a promising particulate system with the potential to improve conventional delivery systems, providing a better loading capacity and targeting specificity whilst promoting multi-drugs loading and single-dose-drug administration.

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“…[163] Jiang and co-workers developed a T2 phage-like Janus NP (AS1411-AuBJNP-ICG) with similar morphology and composition to the T2 phage (Figure 5C). [164] AS1411-AuBJNP-ICG was prepared by adsorbing Au onto bovine serum albumin nanoparticles and modifying the complex with polishing dye ICG. AS1411-AuBJNP-ICG possessed a good tumor-targeting ability and strong photothermal conversion efficiency.…”

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

mentioning

confidence: 99%

Recent Progress in Phage‐Based Nanoplatforms for Tumor Therapy

Li,

Peng,

Feng

et al. 2023

Small

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Nanodrug delivery systems have demonstrated a great potential for tumor therapy with the development of nanotechnology. Nonetheless, traditional drug delivery systems are faced with issues such as complex synthetic procedures, low reproducibility, nonspecific distribution, impenetrability of biological barrier, systemic toxicity, etc. In recent years, phage‐based nanoplatforms have attracted increasing attention in tumor treatment for their regular structure, fantastic carrying property, high transduction efficiency and biosafety. Notably, therapeutic or targeting peptides can be expressed on the surface of the phages through phage display technology, enabling the phage vectors to possess multifunctions. As a result, the drug delivery efficiency on tumor will be vastly improved, thereby enhancing the therapeutic efficacy while reducing the side effects on normal tissues. Moreover, phages can overcome the hindrance of biofilm barrier to elicit antitumor effects, which exhibit great advantages compared with traditional synthetic drug delivery systems. Herein, this review not only summarizes the structure and biology of the phages, but also presents their potential as prominent nanoplatforms against tumor in different pathways to inspire the development of effective nanomedicine.

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Biodegradable T2-phage-like Janus nanoparticles for actively-targeted and chemo-photothermal synergistic therapy

Cited by 11 publications

References 54 publications

Magnetite‐based Janus nanoparticles, their synthesis and biomedical applications

Magnetite‐based Janus nanoparticles, their synthesis and biomedical applications

Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications

Recent Progress in Phage‐Based Nanoplatforms for Tumor Therapy

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