Biodegradable Self-Assembled MPEG-PCL Micelles for Hydrophobic Oridonin Delivery &lt;I&gt;In Vitro&lt;/I&gt;

Xue, Bingxin; Wang, Yingjing; Tang, Xiaohai; Xie, Ping; Wang, Yujun; Luo, Feng; Wu, Chunjie; Qian, Zhiyong

doi:10.1166/jbn.2012.1358

Cited by 49 publications

(31 citation statements)

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“…The release of MTX/PN-H nanoparticles was a little slower than that of MTX/PN-L nanoparticles. Comparing to other anticancer drug loaded polymeric nanoparticles reported previously [23][24][25][26][27], the release of MTX loaded polyrotaxanes nanoparticles was very fast. There were two reasons to explain this phenomenon, one was that the hydrophilicity of MTX was better than other anticancer drugs such as doxorubicin and 9-nitro-20(S)-camptothecin, which resulted faster diffusion from the nanoparticles to themedium.…”

Section: Resultscontrasting

confidence: 60%

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Zhang

et al. 2014

Nano-Micro Lett.

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α-Cyclodextrin/poly(ethylene glycol) (α-CD/PEG) polyrotaxane nanoparticles were prepared via a self-assembly method. Anticancer drug methotrexate (MTX) was loaded in the nanoparticles. The interaction between MTX and polyrotaxane was investigated. The formation, morphology, drug release and in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles were studied. The results show that the MTX could be efficiently absorbed on the nanoparticles, and hydrogen bonds were formed between MTX and α-CDs. The typical channel-type stacking assembly style of polyrotaxane nanoparticles was changed after MTX was loaded. The mean diameter of drug loaded polyrotaxane nanoparticles were around 200 nm and the drug loading content was as high as about 20%. Drug release profiles show that most of the loaded MTX was released within 8 hours and the cumulated release rate was as high as 98%. The blank polyrotaxane nanoparticles were nontoxicity to cells. The in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles was higher than that of free MTX.

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Section: Resultscontrasting

confidence: 60%

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Zhang

et al. 2014

Nano-Micro Lett.

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“…[11][12][13] PEG-PCL polymers are highly biodegradable and biocompatible. 11,13 Therefore, PEG-PCL polymers have been widely used as hydrophobic drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13] PEG-PCL polymers are highly biodegradable and biocompatible. 11,13 Therefore, PEG-PCL polymers have been widely used as hydrophobic drug delivery systems. [11][12][13][14] PEG-PCL lacks bone specificity and cannot deliver drugs targeting the tumor metastasized in the bone niche.…”

Section: Introductionmentioning

confidence: 99%

“…11,13 Therefore, PEG-PCL polymers have been widely used as hydrophobic drug delivery systems. [11][12][13][14] PEG-PCL lacks bone specificity and cannot deliver drugs targeting the tumor metastasized in the bone niche. Therefore, bone-specific moietylinked PEG-PCL nanoparticles might be a suitable carrier of hydrophobic anticancer drugs targeting bone niche.…”

Section: Introductionmentioning

confidence: 99%

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Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

Liu¹,

Zeng²,

Shi

et al. 2017

IJN

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Treatment of cancer metastasized to bone is still a challenge due to hydrophobicity, instability, and lack of target specificity of anticancer drugs. Poly (ethylene glycol)-poly (ε-caprolactone) polymer (PEG-PCL) is an effective, biodegradable, and biocompatible hydrophobic drug carrier, but lacks bone specificity. Polyaspartic acid with eight peptide sequences, that is, (Asp) 8 , has a strong affinity to bone surface. The aim of this study was to synthesize (Asp) 8 -PEG-PCL nanoparticles as a bone-specific carrier of hydrophobic drugs to treat cancer metastasized to bone. 1 H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and transmission electron microscopy data showed that (Asp) 8 -PEG-PCL nanoparticles (size 100 nm) were synthesized successfully. (Asp) 8 -PEG-PCL nanoparticles did not promote erythrocyte aggregation. Fluorescence microscopy showed clear uptake of Nile red-loaded (Asp) 8 -PEG-PCL nanoparticles by cancer cells. (Asp) 8 -PEG-PCL nanoparticles did not show cytotoxic effect on MG63 and human umbilical vein endothelial cells at the concentration of 10–800 μg/mL. (Asp) 8 -PEG-PCL nanoparticles bound with hydroxyapatite 2-fold more than PEG-PCL. Intravenously injected (Asp) 8 -PEG-PCL nanoparticles accumulated 2.7-fold more on mice tibial bone, in comparison to PEG-PCL. Curcumin is a hydrophobic anticancer drug with bone anabolic properties. Curcumin was loaded in the (Asp) 8 -PEG-PCL. (Asp) 8 -PEG-PCL showed 11.07% loading capacity and 95.91% encapsulation efficiency of curcumin. The curcumin-loaded (Asp) 8 -PEG-PCL nanoparticles gave sustained release of curcumin in high dose for >8 days. The curcumin-loaded (Asp) 8 -PEG-PCL nanoparticles showed strong antitumorigenic effect on MG63, MCF7, and HeLa cancer cells. In conclusion, (Asp) 8 -PEG-PCL nanoparticles were biocompatible, permeable in cells, a potent carrier, and an efficient releaser of hydrophobic anticancer drug and were bone specific. The curcumin-loaded (Asp) 8 -PEG-PCL nanoparticles showed strong antitumorigenic ability in vitro. Therefore, (Asp) 8 -PEG-PCL nanoparticles could be a potent carrier of hydrophobic anticancer drugs to treat the cancer metastasized to bone.

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“…Xue et al also used methyl ether poly(ethylene glycol)-polycaprolactone (MPEG-PCL) micelles to entrap the hydrophobic oridonin to prepare ORI-micelles, which have great potential as a transdermal drug delivery system in cancer chemotherapy. 19 In the past decades, many stimuli-response polymers have been synthesized and used as drug carriers based on the differences between normal and targeted sites, including temperature, enzyme, pressure, etc. [20][21][22][23][24][25] As reported, extracellular pH of tumor is weakly acidic (about 6.5-7.2), and the pH values in endosome and lysosome are much lower (4.5~6.5), compared with the normal physiological pH of 7.4.…”

mentioning

confidence: 99%

pH-sensitive micelles self-assembled from polymer brush (PAE-g-cholesterol)-b-PEG-b-(PAE-g-cholesterol) for anticancer drug delivery and controlled release

Huang¹,

Liao²,

Zhang³

et al. 2017

IJN

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Biodegradable Self-Assembled MPEG-PCL Micelles for Hydrophobic Oridonin Delivery <I>In Vitro</I>

Cited by 49 publications

References 0 publications

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

pH-sensitive micelles self-assembled from polymer brush (PAE-<em>g</em>-cholesterol)-<em>b</em>-PEG-<em>b</em>-(PAE-<em>g</em>-cholesterol) for anticancer drug delivery and controlled release

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Biodegradable Self-Assembled MPEG-PCL Micelles for Hydrophobic Oridonin Delivery <I>In Vitro</I>

Cited by 49 publications

References 0 publications

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (&epsilon;-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

pH-sensitive micelles self-assembled from polymer brush (PAE-<em>g</em>-cholesterol)-<em>b</em>-PEG-<em>b</em>-(PAE-<em>g</em>-cholesterol) for anticancer drug delivery and controlled release

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Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone