Biodegradable polymers

Chesterman, Julian P.; Zhang, Zheng; Ortiz, Ophir; Goyal, Ritu; Kohn, Joachim

doi:10.1016/b978-0-12-818422-6.00019-8

Cited by 8 publications

(4 citation statements)

References 253 publications

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“…Alteration of inert molecular structures may also influence the immune reaction against transplanted grafts. In normal conditions, elastin, which constitutes approximately two-thirds of elastic ligaments, half of the blood vessels, one-third of the lungs, and 3% of dermis dry weight [104], does not usually undergo turnover [105]. During the decellularization of such tissues, elastin may be denatured that leads to the release of elastin particles; directly via the impact of harsh agents such as SDS and trypsin or indirectly via the depletion of GAGs, which have a critical role in protecting elastin from protease activity [46,[106][107][108].…”

Section: The Role Of Ecm Alteration In the Immunogenicity Of Decellul...mentioning

confidence: 99%

Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

et al. 2023

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Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to address the donor shortage as well as immunologic rejection attributed to cells in conventional tissue/organ transplantation. Decellularization, as the key process in manufacturing ECM scaffolds, removes immunogen cell materials and significantly alleviates the immunogenicity and biocompatibility of derived scaffolds. However, the application of these bioscaffolds still confronts major immunologic challenges. This review discusses the interplay between damage-associated molecular patterns (DAMPs) and antigens as the main inducers of innate and adaptive immunity to aid in manufacturing biocompatible grafts with desirable immunogenicity. It also appraises the impact of various decellularization methodologies (i.e., apoptosis-assisted techniques) on provoking immune responses that participate in rejecting allogenic and xenogeneic decellularized scaffolds. In addition, the key research findings regarding the contribution of ECM alterations, cytotoxicity issues, graft sourcing, and implantation site to the immunogenicity of decellularized tissues/organs are comprehensively considered. Finally, it discusses practical solutions to overcome immunogenicity, including antigen masking by crosslinking, sterilization optimization, and antigen removal techniques such as selective antigen removal and sequential antigen solubilization.

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Section: The Role Of Ecm Alteration In the Immunogenicity Of Decellul...mentioning

confidence: 99%

Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

et al. 2023

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“…e annual consumption of gelatin and collagen in the medical sector is about 50,000 MT. Collagen and gelatin are mostly used in medical and pharmaceutical applications due to their biocompatibility with physiological situations and biodegradability [46,47].…”

Section: Application In Medical and Pharmaceutical Industriesmentioning

confidence: 99%

A Review on Utilization Routes of the Leather Industry Biomass

Ayele

Limeneh

Tesfaye

et al. 2021

Advances in Materials Science and Engineering

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The use of biomass to produce bioenergy and biomaterials is considered a sustainable alternative to depleting fossil fuel resources. The world tanneries consume 8–9 MT of skin and hide every year producing 1.4 MT of solid waste. Most of the solid biomass generated from tanneries is disposed of as waste in the environment using either landfilling or thermal incineration. Disposal of this waste into the environment affects the ecosystem, causing bad odor (air pollution) and has an antagonistic impact on the environment. Due to this, European Union legislation bans the landfilling of biomass. This study aims to comprehensively review the possible valorization routes of leather processing industry biomass into high-value biomaterials. Leather biomass (trimmings, shaving, splitting, and buffing dust) mainly contain 30%–35% collagen protein, which is produced by acid or alkali hydrolysis. The biopolymers obtained from leather industry biomass can be utilized in the production of several high-value materials. In addition, leather processing industry biomass also contains fat, which can be converted into a bio-surfactant, and other useful biomaterials. Keratin protein can also be extracted from the hair waste of hides and skins. The increased demand for biomaterials makes the using of leather industry biomass very attractive. From this study, it can be concluded that the conversions of leather processing industry waste to valuable biomaterial can protect the environment, generate additional income for leather industries, and pave way for sustainable and renewable biomaterials production.

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“…Essas propriedades dos polímeros estão relacionadas com a natureza desses monômeros (ASHTER et al, 2016;MEHTIÖ, et al, 2015). Em 1922, Hermann Staudinger propôs que as propriedades dos polímeros podem ser melhor explicadas assumindo que eles consistem em longas cadeias de monômeros ligados entre si, repetidas regularmente (CHESTERMAN et al, 2020). As variações muito pequenas nas estruturas químicas do polímero (monômero), podem levar a grandes alterações em sua biodegradabilidade (ASHTER et al, 2016).…”

Section: Monômerosunclassified

Adsorção De Íons Cádmio Por Derivados Carboximetilados E Sulfatados De Quitosana

Almeida¹,

Lima²,

Coelho³

et al. 2020

A Química Nas Áreas Natural, Tecnológica E Sustentável

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Direitos para esta edição cedidos à Atena Editora pelos autores.Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.A Atena Editora não se responsabiliza por eventuais mudanças ocorridas nos endereços convencionais ou eletrônicos citados nesta obra.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação.

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Biodegradable polymers

Cited by 8 publications

References 253 publications

Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

A Review on Utilization Routes of the Leather Industry Biomass

Adsorção De Íons Cádmio Por Derivados Carboximetilados E Sulfatados De Quitosana

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