Biodegradable polymers in drug delivery and oral vaccination

Jana, Pradip; Shyam, Mousumi; Singh, Sneha; Jayaprakash, Venkatesan; Dev, Abhimanyu

doi:10.1016/j.eurpolymj.2020.110155

Cited by 111 publications

(57 citation statements)

References 102 publications

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“…Thirdly, the immunogenicity and biological safety of the natural polysaccharide‐based conjugates and drug delivery systems need to be thoroughly evaluated. [ 120,121 ] Natural glycans such as HA have already been extensively used as injectable skin fillers in the cosmetic industry, which is considered relatively safe as an implant material. [ 122 ] Both HA and CS have already been formulated as an intraarticular injection to alleviate joint pains in knees affected by arthritis.…”

Section: Discussionmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti‐virus, anti‐cancer, anti‐inflammation, and anti‐oxidation activities. Herein, this review highlights recent progress in the polysaccharide‐based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.

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Section: Discussionmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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“…Polymers based on amino acid monomers have gained significant attention in drug delivery. Natural amide-based polymers such as gelatin and albumin are widely used in the preparation of biodegradable microcapsules and microspheres [9]. Synthetic poly(amino acid)s are also investigated in biomedical/drug delivery applications as they are structurally similar with naturally occurring proteins.…”

Section: Polyamide Polymers Used In Drug Deliverymentioning

confidence: 99%

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

Boddu

Bhagav

Karla

et al. 2021

JFB

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Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included.

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“…Insulin complexing agent such as diethylene triaminepentaacetic acid was used to conjugate insulin with the nanoparticle. This proved beneficiary by opening the tight junctions and preventing proteolytic degradation of the therapeutic proteins [103]. Further, in a study synthesis of nanoparticles using chitosan, γ-glutamic acid, and DTPA resulted in increased insulin absorption through the intestine.…”

Section: Nanoparticlesmentioning

confidence: 99%

Current Status and Perspectives of Oral Therapeutic Protein and Peptide Formulations: A Review

Manu

Firdose

Jayanthi

et al. 2021

JPRI

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Medicinal formulations have evolved from the use of small molecules that act by blocking various receptors. On the contrary, therapeutic proteins are a class of medicines that have gained increased popularity owing to its low toxicity, high stability and exquisite specificity. Oral delivery of protein drugs is a very interesting but a highly challenging area of medicine that requires advancements in terms of bioavailability of oral drugs. The main objective of the present review is to provide a systematic overview of the various physiological barriers of delivery of therapeutic proteins and novel approaches available in this field in order to counter these physiological barriers. Advances in terms of inhibitors of proteases, permeation enhancers, mucoadhesives, short peptide conjugates, particulate delivery system including nanoparticles. Oral therapeutic proteins face challenges with regard to oral bioavailability, stability of the protein and reproducibility. Among the various strategies, a co-administration of permeation enhancers with protease inhibitors have proven most effective, while particulate delivery system is still under clinical studies in order to be establishes as a method. Overall, a thorough and focused research with sufficient knowledge on the structure-function relationship, substrate specificity and physiological parameters can deliver a potent therapeutic protein with high efficiency.

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Biodegradable polymers in drug delivery and oral vaccination

Cited by 111 publications

References 102 publications

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

Current Status and Perspectives of Oral Therapeutic Protein and Peptide Formulations: A Review

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