Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu, Yining; Xue, Qixuan; Fu, Yao

doi:10.1002/mabi.202100162

Cited by 8 publications

(3 citation statements)

References 119 publications

(119 reference statements)

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“…Relevant animal experiments have shown that ephedra polysaccharides can improve lung disease injury and inhibit inflammation, apoptosis, and oxidative stress by regulating the level of immune cells such as T helper cells. Codium fragile polysaccharide can induce the activation of mouse dendritic cells in vivo and directly induce natural killer cells to produce IFN-γ in vitro, thereby promoting the apoptosis of target cells and contributing to immune anti-cancer[ 23 - 25 ].…”

Section: Mechanism Of Action and Intervention Strategies Of Common Im...mentioning

confidence: 99%

Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

Zhou,

Fang,

Tian

et al. 2024

World J Diabetes

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Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease. Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes. With the development of immunological technology, many studies have shown that diabetic nephropathy is an immune complex disease, and that most patients have immune dysfunction. However, the immune response associated with diabetic nephropathy and autoimmune kidney disease, or caused by ischemia or infection with acute renal injury, is different, and has a com-plicated pathological mechanism. In this review, we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism, to provide guidance and advice for early intervention and treatment of diabetic nephropathy.

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Section: Mechanism Of Action and Intervention Strategies Of Common Im...mentioning

confidence: 99%

Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

Zhou,

Fang,

Tian

et al. 2024

World J Diabetes

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show abstract

“…Natural and synthetic polymers, each with distinct advantages and limitations, are integral to the development of biomedical materials for bone tissue engineering. Natural polymers, including chitosan, alginate, gelatin, glycosaminoglycan, collagen, fibrin and hyaluronic acid, possess structural and biochemical properties similar to those of the natural bone organic matrix [ 36 , 37 ]. Some are extensively employed in creating bio-dental materials for oral drug delivery, periodontitis treatment via bone tissue engineering and dentin-pulp regeneration [ 38 ].…”

Section: Classification Of Current Bone Repair Materialsmentioning

confidence: 99%

Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies

Li,

Wang,

Feng

et al. 2024

Regenerative Biomaterials

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The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing the repair and regeneration of oral-maxillofacial bone defects. Numerous characteristics should be noticed in oral-maxillofacial bone repair, such as irregular morphology of bone defects, homeostasis between hosts and microorganisms in the oral cavity, and complex periodontal structures that facilitate epithelial ingrowth. Therefore, oral-maxillofacial bone repair necessitates restoration materials that adhere to stringent and specific demands. This review starts with exploring these particular requirements by introducing the particular characteristics of oral-maxillofacial bones, and then summarizes the classifications of current bone repair materials in respect of composition and structure. Additionally, we discuss the modifications in current bone repair materials including improving mechanical properties, optimizing surface topography and pore structure, and adding bioactive components such as elements, compounds, cells, and their derivatives. Ultimately, we organize a range of potential optimization strategies and future perspectives for enhancing oral-maxillofacial bone repair materials, including physical environment manipulation, oral microbial homeostasis modulation, osteo-immune regulation, smart stimuli-responsive strategies and multifaceted approach for poly-pathic treatment, in the hope of providing some insights for researchers in this field. In summary, this review analyzes the complex demands of oral-maxillofacial bone repair, especially for periodontal and alveolar bone, concludes multifaceted strategies for corresponding biomaterials, and aims to inspire future research in the pursuit of more effective treatment outcomes.

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“…These innovations leverage the epithelial enhanced permeability and retention (eEPR) effect to precisely target inflammatory tissues. [25,26] Micro-/nanoparticles can passively accumulate within inflamed colonic tissues, exploiting increased vascular network permeability, disruptions in intercellular connections, and mucous layer damage. [27] Furthermore, the UC microenvironment, characterized by reduced pH levels, heightened levels of reactive oxygen species, and overexpressed enzymes (𝛼-amylase, neutrophil elastase, myeloperoxidase, etc.…”

Section: Introductionmentioning

confidence: 99%

Colon‐Targeted Oral Delivery of Hydroxyethyl Starch–Curcumin Microcapsules Loaded with Multiple Drugs Alleviates DSS‐Induced Ulcerative Colitis in Mice

Huang,

Zou,

et al. 2023

Macromolecular Bioscience

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Combination therapy through colon‐targeted oral delivery of multiple drugs presents a promising approach for effectively treating ulcerative colitis (UC). However, the codelivery of drugs with diverse physicochemical properties in a single formulation remains a formidable challenge. Here, microcapsules are designed based on hydroxyethyl starch–curcumin (HES─CUR) conjugates to enable the simultaneous delivery of hydrophobic dexamethasone acetate (DA) and hydrophilic cefazolin sodium, yielding multiple drug‐loaded microcapsules (Crohn's‐disease/DA‐loaded HES─CUR microcapsules, CDHC‐MCs) tailored for colon‐targeted therapy of UC. Thorough characterization confirms the successful synthesis and exceptional biocompatibility of CDHC‐MCs. Biodistribution studies demonstrate that the microcapsules exhibit an impressive inflammatory targeting effect, accumulating preferentially in inflamed colons. In vivo experiments employing a dextran‐sulfate‐sodium‐induced UC mouse model reveal that CDHC‐MCs not only arrest UC progression but also facilitate the restoration of colon length and alleviate inflammation‐related splenomegaly. These findings highlight the potential of colon‐targeted delivery of multiple drugs within a single formulation as a promising strategy to enhance UC treatment, and the CDHC‐MCs developed in this study hold great potential in developing novel oral formulations for advanced UC therapy.

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Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Cited by 8 publications

References 119 publications

Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies

Colon‐Targeted Oral Delivery of Hydroxyethyl Starch–Curcumin Microcapsules Loaded with Multiple Drugs Alleviates DSS‐Induced Ulcerative Colitis in Mice

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