Biodegradable polycation and plasmid DNA multilayer film for prolonged gene delivery to mouse osteoblasts

Lu, Zhenzhen; Wu, Juan; Sun, Tianmeng; Jing, Jian; Yan, Lifeng; Wang, Jun

doi:10.1016/j.biomaterials.2007.10.033

Cited by 71 publications

(68 citation statements)

References 50 publications

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“…Synthesis of new cationic polymers is one of important developments in the field of PEMs for gene delivery. Lu et al [214] reported a biodegradable polycation poly(2-aminoethyl propylene phosphate), which could form multilayers with plasmid DNA (pDNA) and lead to prolonged pDNA delivery up to 2 months. Reducible polycations such as those containing disulfide bonds are also of interest for triggering gene release from PEM films under reductive conditions in the presence of DTT for instance.…”

Section: Localized Gene Therapy Of Dna and Rnamentioning

confidence: 99%

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Boudou¹,

Crouzier²,

Ren³

et al. 2010

Advanced Materials

686

702

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The design of advanced functional materials with nanometer- and micrometer-scale control over their properties is of considerable interest for both fundamental and applied studies because of the many potential applications for these materials in the fields of biomedical materials, tissue engineering, and regenerative medicine. The layer-by-layer deposition technique introduced in the early 1990s by Decher, Moehwald, and Lvov is a versatile technique, which has attracted an increasing number of researchers in recent years due to its wide range of advantages for biomedical applications: ease of preparation under "mild" conditions compatible with physiological media, capability of incorporating bioactive molecules, extra-cellular matrix components and biopolymers in the films, tunable mechanical properties, and spatio-temporal control over film organization. The last few years have seen a significant increase in reports exploring the possibilities offered by diffusing molecules into films to control their internal structures or design "reservoirs," as well as control their mechanical properties. Such properties, associated with the chemical properties of films, are particularly important for designing biomedical devices that contain bioactive molecules. In this review, we highlight recent work on designing and controlling film properties at the nanometer and micrometer scales with a view to developing new biomaterial coatings, tissue engineered constructs that could mimic in vivo cellular microenvironments, and stem cell "niches."

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Section: Localized Gene Therapy Of Dna and Rnamentioning

confidence: 99%

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Boudou¹,

Crouzier²,

Ren³

et al. 2010

Advanced Materials

686

702

View full text Add to dashboard Cite

show abstract

“…[18,64,82] We have recently reported a layer-by-layer assembled multilayer film from a degradable cation PPE-EA and plasmid DNA for prolonged gene delivery. [83] The multilayer film degraded upon incubation in phosphate buffered saline at 37 8C and sustained the release of bioactive plasmid DNA for up to two months. The PPE surface facilitated mouse osteoblast cell adhesion, and the sustained DNA release directly prolonged gene expression in osteoblast cells cultured on the surface.…”

Section: Biocompatibility Of Ppesmentioning

confidence: 99%

Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications

Wang

Yuan

et al. 2009

Macromolecular Bioscience

Self Cite

188

155

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Polyphosphoesters (PPEs) with repeating phosphoester bonds in the backbone are structurally versatile, biocompatible, and biodegradable through hydrolysis as well as enzymatic digestion under physiological conditions. They are appealing for biological applications because of their potential functionality, biocompatibility, and similarity to biomacromolecules such as nucleic acids. The expanding scope of PPEs in materials science, especially as biomaterials, is described in this review. We mainly focus on controlled synthetic methods of PPEs, which provide access to novel and complex polymer structures, especially for block copolymers. The hydrolytic and enzymatic degradation of PPEs, thermoresponsive PPEs, and biomedical applications have also been discussed.

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“…18 In addition, drug molecules can be covalently bonded to polyelectrolyte multilayer nanofilms. 12,30,31 A drug delivery platform in hyaluronan/chitosan or HA/CHI multilayer nanofilms was developed. Paclitaxel, a chemotherapeutic agent, was conjugated on the HA chain within the nanofilms, and its drug bioactivity was found to be retained.…”

Section: Dovepressmentioning

confidence: 99%

Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems

Jiang

Barnett²,

2009

NSA

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Biodegradable polycation and plasmid DNA multilayer film for prolonged gene delivery to mouse osteoblasts

Cited by 71 publications

References 50 publications

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications

Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems

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