Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications

Wang, Yucai; Yuan, Youyong; Du, Jin‐Zhi; Yang, Xianzhu; Wang, Jun

doi:10.1002/mabi.200900253

Cited by 188 publications

(157 citation statements)

References 93 publications

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“…They found that as the temperature was increased above the LCST the micelles became more hydrophobic and formed aggregates in a reversible way [163,164]. The micelles were found to be both biodegradable and non cytotoxic showing a promising drug delivery vector [163,164].…”

Section: Particlesmentioning

confidence: 99%

See 1 more Smart Citation

Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Particlesmentioning

confidence: 99%

“…Jun Wang et al have produced a series of thermoresponsive micellar nanoparticles from PVCL and polyphosphoester and examined their cell change in size with temperature [163,164]. They found that as the temperature was increased above the LCST the micelles became more hydrophobic and formed aggregates in a reversible way [163,164].…”

Section: Particlesmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…[27][28][29] As previously reported, polyphosphoesters featuring a linear molecular structure can be synthesized through the ringopening polymerization reaction of EEP in tetrahydrofuran, utilizing ROH or RNH 2 as the co-initiator, and Sn(Oct) 2 as the catalyst. 30 In this work, the PAEEP-PLLA copolymer was synthesized as illustrated in Figure 2.…”

Section: Results and Discussion Synthesis Of Paeep-plla Copolymermentioning

confidence: 86%

Novel lactoferrin-conjugated amphiphilic poly(aminoethyl ethylene phosphate)/poly(L-lactide) copolymer nanobubbles for tumor-targeting ultrasonic imaging

Luo¹,

Liang²,

Zhang³

et al. 2015

IJN

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In the study reported here, a novel amphiphilic poly(aminoethyl ethylene phosphate)/poly(L-lactide) (PAEEP-PLLA) copolymer was synthesized by ring-opening polymerization reaction. The perfluoropentane-filled PAEEP-PLLA nanobubbles (NBs) were prepared using the O 1 /O 2 /W double-emulsion and solvent-evaporation method, with the copolymer as the shell and liquid perfluoropentane as the core of NBs. The prepared NBs were further conjugated with lactoferrin (Lf) for tumor-cell targeting. The resulting Lf-conjugated amphiphilic poly(aminoethyl ethylene phosphate)/poly(L-lactide) nanobubbles (Lf-PAEEP-PLLA NBs) were characterized by photon correlation spectroscopy, polyacrylamide gel electrophoresis, Fourier transform infrared spectroscopy, and transmission electron microscopy. The average size of the Lf-PAEEP-PLLA NBs was 328.4±5.1 nm, with polydispersity index of 0.167±0.020, and zeta potential of −12.6±0.3 mV. Transmission electron microscopy imaging showed that the Lf-PAEEP-PLLA NBs had a near-spherical structure, were quite monodisperse, and there was a clear interface between the copolymer shell and the liquid core inside the NBs. The Lf-PAEEP-PLLA NBs also exhibited good biocompatibility in cytotoxicity and hemolysis studies and good stability during storage. The high cellular uptake of Lf-PAEEP-PLLA NBs in C6 cells (low-density lipoprotein receptor-related protein 1-positive cells) at concentrations of 0–20 µg/mL indicated that the Lf provided effective targeting for brain-tumor cells. The in vitro acoustic behavior of Lf-PAEEP-PLLA NBs was evaluated using a B-mode clinical ultrasound imaging system. In vivo ultrasound imaging was performed on tumor-bearing BALB/c nude mice, and compared with SonoVue ® microbubbles, a commercial ultrasonic contrast agent. Both in vitro and in vivo ultrasound imaging indicated that the Lf-PAEEP-PLLA NBs possessed strong, long-lasting, and tumor-enhanced ultrasonic contrast ability. Taken together, these results indicate that Lf-PAEEP-PLLA NBs represent a promising nano-sized ultrasonic contrast agent for tumor-targeting ultrasonic imaging.

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“…The pentavalency of phosphorous enables covalent linkages to prepare prodrugs of this polymer (1). PPE and its composites have been used in gene delivery, drug delivery, and in tissue engineering applications (31). PPE and its copolymers can form films, gels, micelles, and particles (1).…”

Section: Poly(α-hydroxy Acids)mentioning

confidence: 99%

Biodegradable Polymers: Medical Applications

Kunduru

Basu

Domb

2016

Encyclopedia of Polymer Science and Technology

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Biodegradable polymers are the “green materials” of the future. They break down into smaller chemical fragments and are finally eliminated from the body. Biodegradable polymers have been used for more than 50 years with diverse applications such as surgical sutures, wound dressings, tissue regeneration, enzyme immobilization, controlled drug delivery and gene delivery, tissue engineering scaffold, cryopreservation, nanotechnology, medical implants and devices, prosthetics, augmentation, cosmetics, sanitation products, coatings, adhesives, and many more. This article reviews synthetic (esters, amides, ethers, urethanes) and natural (polysaccharides and proteins) biodegradable polymers, highlighting their biomedical applications.

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Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications

Cited by 188 publications

References 93 publications

Thermoresponsive Polymers for Biomedical Applications

Thermoresponsive Polymers for Biomedical Applications

Novel lactoferrin-conjugated amphiphilic poly(aminoethyl ethylene phosphate)/poly(L-lactide) copolymer nanobubbles for tumor-targeting ultrasonic imaging

Biodegradable Polymers: Medical Applications

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