Biodegradable poly(d,l-lactic acid)-poly(ethylene glycol)-monomethyl ether diblock copolymers: structures and surface properties relevant to their use as biomaterials

Lucke, Andrea; Teßmar, Jörg; Schnell, Edith; Schmeer, Georg; Göpferich, Achim

doi:10.1016/s0142-9612(00)00103-4

Cited by 165 publications

(121 citation statements)

References 32 publications

Supporting

Mentioning

111

Contrasting

Order By: Relevance

“…The block copolymer was synthesized using standard ring opening polymerization of L-Lactide and mono hydroxy PEG with staneous octoate as catalyst [34]. Briefly, first to remove any trace of water, the starting materials (2.5 mmol of poly(ethylene glycol)-monomethyl ether 5 kDa and 2 kDa and 70 mmol of L-lactide) were each dissolved in 150 ml toluene separately in a round-bottomed flask.…”

Section: Synthesis Of Micelle Components Plla-b-peg and Plla-b-pegmalmentioning

confidence: 99%

TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors

Sethuraman

Bae

2007

Journal of Controlled Release

318

205

View full text Add to dashboard Cite

A novel drug targeting system for acidic solid tumors has been developed based on ultra pH sensitive polymer and cell penetrating TAT. The delivery system consisted of two components: 1) A polymeric micelle that has a hydrophobic core made of Poly(L-lactic acid) (PLLA) and a hydrophilic shell consisting of Polyethylene Glycol (PEG) conjugated to TAT (TATmicelle), 2) An ultra pH sensitive diblock copolymer of poly(methacryloyl sulfadimethoxine) (PSD) and PEG (PSD-b-PEG). The anionic PSD is complexed with cationic TAT of the micelles to achieve the final carrier, which could systemically shield the micelles and expose them at slightly acidic tumor pH. TATmicelles had particle sizes between 20 to 45 nm and their critical micelle concentrations were 3.5 mg/L to 5.5 mg/ L. The TATmicelles, upon mixing with pH sensitive PSD-b-PEG, showed slight increase in particle size between pH 8.0 and 6.8 (60-90 nm), indicating complexation. As the pH was decreased (pH 6.6 to 6.0) two populations were observed, one that of normal TAT micelles (45 nm) and the other of aggregated hydrophobic PSD-b-PEG. Zeta potential measurements showed similar trend substantiating the shielding/deshielding process. Flowcytometry and confocal microscopy showed significantly higher uptake of TAT micelles at pH 6.6 compared to pH 7.4 indicating shielding at normal pH and deshielding at tumor pH. The flowcytometry indicated that the TAT not only translocates into the cells but is also seen on the surface of the nucleus. These results strongly indicate that the above drug loaded micelles would be able to target any hydrophobic drug near the nucleus.

show abstract

Section: Synthesis Of Micelle Components Plla-b-peg and Plla-b-pegmalmentioning

confidence: 99%

TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors

Sethuraman

Bae

2007

Journal of Controlled Release

318

205

View full text Add to dashboard Cite

show abstract

“…Strong bonding with the host bone, active bone ingrowth into the graft, and bioabsorbability are equally desirable. Although scaffolds can be constructed from numerous materials, the primary materials studied mostly revolve around different polymers such as polylactic acid [24,25] , polyglycolic acid [26] , polyurethane [27] , and a number of copolymers [28][29][30] . Other polymeric materials studied included polyanhydrides, polyorthoesters, polycaprolactones, polycarbonates, and polyfumarates.…”

Section: Introductionmentioning

confidence: 99%

Bioceramics for Tissue Engineering Applications â€“ A Review

Oh¹,

Oh²,

Appleford³

et al. 2006

American J. of Biochemistry and Biotechnology

127

View full text Add to dashboard Cite

Three dimensional (3-D) scaffolds have been explored in an attempt to persuade the body to heal or repair tissues that do not do so spontaneously. Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. However, the material and 3-D scaffolds ideal for optimal regeneration of missing or lost tissues has not been identified. While current materials and techniques have met with varying successes, each exhibits limitations that must be addressed. In addition, despite the large amount of research in the area of 3-D scaffolds for bone tissue engineering that has been performed over the past decade, there is an overall lack of success in bringing this technology to the clinic, especially for porous scaffolds used to restore large bone defects. This review paper will focus on the use of calcium phosphate (CaP) materials used for tissue engineering, the different known methods of scaffold synthesis, and some of the significant in vitro, in vivo, and clinical outcomes when these CaP scaffolds were used in patients.

show abstract

“…Another primary materials studied mostly to fabricate scaffolds are polymers such as polylactic acid [35,36], polyglycolic acid [37], polyurethane [38], and a number of copolymers [39][40][41]. Natural polymer-based scaffolds have excellent bioactivity, biodegradability but poor mechanical properties.…”

Section: Bioceramic Scaffold Materialsmentioning

confidence: 99%

Bioceramic Scaffolds

Amin¹,

Ewais²

2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

View full text Add to dashboard Cite

Millions of peoples in the world suffer from their bone damage tissues by disease or trauma. Every day, thousands of surgical procedures are performed to replace or repair these tissues. The availability of these tissues is a big problem, and their costs are expensive. The repair of these defects has become a major clinical and socioeconomic need with the increase of aging population and social development. The emerge of tissue engineering (TE) is considered as a glimmer of hope to contribute in solving this problem. It aims at the regeneration of damaged tissues with restoring and maintaining the function of human bone tissues using the combination of cell biology, materials science, and engineering principles. In this chapter, the current state of the tissue engineering in particular bioceramic scaffolds was discussed. Concept of tissue engineering was explored. Bioceramic scaffold materials, their processing techniques, challenges taken into consideration the design of the scaffolds, and their in-vitro and in-vivo studies were highlighted. The scaffolds with extra-functionalities such as drug release ability and clinical applications were mentioned.

show abstract

Biodegradable poly(d,l-lactic acid)-poly(ethylene glycol)-monomethyl ether diblock copolymers: structures and surface properties relevant to their use as biomaterials

Cited by 165 publications

References 32 publications

TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors

TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors

Bioceramics for Tissue Engineering Applications â€“ A Review

Bioceramic Scaffolds

Contact Info

Product

Resources

About