Biodegradable CoS2 nanoclusters for photothermal-enhanced chemodynamic therapy

Wang, Xianwen; Zhong, Xiaoyan; Zha, Zhengbao; He, Gang; Miao, Zhaohua; Lei, Huali; Luo, Qunyi; Zhang, Rui; Liu, Zhuang; Cheng, Liang

doi:10.1016/j.apmt.2019.100464

Cited by 63 publications

(43 citation statements)

References 49 publications

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“…Based on the Arrhenius equation, the rate of chemical reactions is positively related to temperature [ 22 ]. Starting from the basic principle that raising temperature can accelerate the rate of chemical reactions, increasing temperature of the bacterial infection sites to enhance the catalytic rate of nanozymes is an effective strategy [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Wang

Shi

Zha

et al. 2021

Bioactive Materials

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Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits their antibacterial properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. Cu SASs/NPC have stronger peroxidase-like catalytic activity, glutathione (GSH)-depleting function, and photothermal property compared with non-Cu-doped NPC, indicating that Cu doping significantly improves the catalytic performance of nanozymes. Cu SASs/NPC can effectively induce peroxidase-like activity in the presence of H 2 O 2 , thereby generating a large amount of hydroxyl radicals (•OH), which have a certain killing effect on bacteria and make bacteria more susceptible to temperature. The introduction of near-infrared (NIR) light can generate hyperthermia to fight bacteria, and enhance the peroxidase-like catalytic activity, thereby generating additional •OH to destroy bacteria. Interestingly, Cu SASs/NPC can act as GSH peroxidase (GSH-Px)-like nanozymes, which can deplete GSH in bacteria, thereby significantly improving the sterilization effect. PTT-catalytic synergistic antibacterial strategy produces almost 100% antibacterial efficiency against Escherichia coli ( E. coli ) and methicillin-resistant Staphylococcus aureus ( MRSA ). In vivo experiments show a better PTT-catalytic synergistic therapeutic performance on MRSA-infected mouse wounds. Overall, our work highlights the wide antibacterial and anti-infective bio-applications of Cu single-atom-containing catalysts.

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Section: Introductionmentioning

confidence: 99%

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Wang

Shi

Zha

et al. 2021

Bioactive Materials

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211

184

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“…Monodisperse and uniform ND nanozymes were successfully prepared by a facile PVP-assisted solvothermal method (Figure 1A), and the formation mechanism could be explained by the La Mer scheme based on the previous report (Wang et al, 2020b). Transmission electron microscopic (TEM) images of as-prepared ND nanozymes clearly revealed a uniform spherical morphology with an average diameter of 112.31 G 24.07 nm (Figures 1B,1C,and 1E).…”

Section: Characterization Of Nd Nanozymesmentioning

confidence: 61%

“…From the basic principle that increasing temperature can accelerate the chemical reaction rate, it is an effective strategy to improve the catalytic rate of HRP-like nanozymes by raising the temperature of bacterial infection site (Tang et al, 2017;Wang et al, 2019bWang et al, , 2020bYang et al, 2019a). Among all the strategies currently reported for hyperthermia, photothermal therapy (PTT) is a new type of bactericidal therapy that employs photothermal agents (PTAs) to convert near-infrared light into overheating to destroy different types of pathogens and microorganisms, which is considered as one of the most promising treatment methods due to its less-invasive nature and high selectivity (Liu et al, 2019a).…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nickel Disulfide Nanozymes with GSH-Depleting Function for High-Efficiency Photothermal-Catalytic Antibacterial Therapy

et al. 2020

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Bacterial infections caused by pathogens have always been a thorny issue that threatens human health, and there is urgent need to develop a new generation of antimicrobial nano-agents and treatments. Herein, biodegradable nickel disulfide (ND) nanozymes as excellent antibacterial agents that integrate excellent photothermal performance, nano-catalysis property, and glutathione (GSH)depleting function have been successfully constructed. The ND nanozymes can effectively catalyze the decomposition of H 2 O 2 to produce ,OH, and the hyperthermia of ND nanozymes generated by photothermal therapy (PTT) can further increase its catalytic activity, which provides rapid and effective bacterial killing effect compared with nano-catalytic treatment or PTT alone. Surprisingly, the ND nanozymes have the ability of GSH consumption, thus enhancing its sterilization effect. Moreover, the ND nanozymes are biodegradable nanomaterials that do not cause any significant toxicity in vivo. Collectively, the ND nanozymes with excellent photothermal performance, catalytic activity, and GSH-depleting function are used for high-efficiency sterilization.

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“…Meanwhile, Mn 2+ released from the HMCMD NPs through a redox reaction between MnO 2 and intracellular GSH promoted the decomposition of intracellular H 2 O 2 by the Fenton-like reaction to generate highly toxic •OH for synergistic chemotherapy/CDT/PDT. Lastly, one study prepared CoS 2 NPs via the self-assembly of CoS 2 nanosclusters [ 182 ]. Co 2+ -mediated Fenton-like reaction enhanced the CoS 2 mediated-PTT.…”

Section: Fenton and Fenton-like Reactions-mediated Combination Therapymentioning

confidence: 99%

Chemodynamic nanomaterials for cancer theranostics

et al. 2021

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It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O2). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O2 can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.

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Biodegradable CoS2 nanoclusters for photothermal-enhanced chemodynamic therapy

Cited by 63 publications

References 49 publications

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Biodegradable Nickel Disulfide Nanozymes with GSH-Depleting Function for High-Efficiency Photothermal-Catalytic Antibacterial Therapy

Chemodynamic nanomaterials for cancer theranostics

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