Biodegradable Nickel Disulfide Nanozymes with GSH-Depleting Function for High-Efficiency Photothermal-Catalytic Antibacterial Therapy

Abstract

Bacterial infections caused by pathogens have always been a thorny issue that threatens human health, and there is urgent need to develop a new generation of antimicrobial nano-agents and treatments. Herein, biodegradable nickel disulfide (ND) nanozymes as excellent antibacterial agents that integrate excellent photothermal performance, nano-catalysis property, and glutathione (GSH)depleting function have been successfully constructed. The ND nanozymes can effectively catalyze the decomposition of H 2 O 2 to produce ,OH, and the hyperthermia of ND nanozymes generated by photothermal therapy (PTT) can further increase its catalytic activity, which provides rapid and effective bacterial killing effect compared with nano-catalytic treatment or PTT alone. Surprisingly, the ND nanozymes have the ability of GSH consumption, thus enhancing its sterilization effect. Moreover, the ND nanozymes are biodegradable nanomaterials that do not cause any significant toxicity in vivo. Collectively, the ND nanozymes with excellent photothermal performance, catalytic activity, and GSH-depleting function are used for high-efficiency sterilization.

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

“…Unfortunately, the low catalytic activity of nanozymes greatly limits their antibacterial effects [ 18 ]. In addition, it is also worth noting that the microenvironments of the infection sites usually have abnormally high expression of glutathione (GSH) levels, which are caused by anaerobic glycolysis, greatly reducing the catalytic therapeutic effects of nanozymes [ [19] , [20] , [21] ]. Thus, there is still a great need for antibacterial nanozymes with enhanced catalytic activity and GSH-depleting function.…”

Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy

“…The mild photothermal effect can increase tumor blood flow, an thereby improving tumor oxygenation to boost the ROS generation from CDT and SDT 46 . In addition, the slight temperature increment is able to improve the SDT and CDT catalytic performance and increase the ROS generation 47 . From the temperature profiles of Si-Pt NCs with five cycles, no obvious changes were observed during each cycle ( Figure S8 ) , which implied that Si-Pt NCs had good photothermal stability.…”

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

“…Besides the therapeutic platform, incorporating Au NPs into mesoporous carbon can facilitate the action of POD mimitic activity and generate ROS for intracellular oxidative damage of cancer cells. As shown in Figure 5 In addition to the previously mentioned advantages of nanozymes in cancer therapeutics, several further POD mimetic nanozyme platforms such as Au@Co-Fe NPs [72], CuO Nanorods [73], Fe3O4@MoS2-Ag nanozyme [74], Pd nanocrystals [75], and Pt hollow nanodendrites [76], N-doped spongelike carbon spheres (N-SCSs) [77], PEGylated palladium nanozyme (Pd-PEG) [78], tungsten sulfide quantum dots (WS2 QDs) [79], nickel disulfide (ND) nanozyme [80], iridium (Ir) nanoplates [81] and MoS2 [82] have been successfully utilized in antibacterial applications with significant outcomes. Table 1 summarizes POD-based nanozyme applications in cancer phototherapeutics.…”