Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy

Abstract

Sonodynamic therapy (SDT) triggered by ultrasound (US) can overcome pivotal limitations of photo-therapy owing to its high depth-penetration and low phototoxicity. However, there is still a need to develop more efficient sonosensitizes to enhance the therapy efficiency. Methods: In this study, Pt nanoparticles (Pt NPs) are reduced on silicon nanowires (SiNWs) by in situ reduction to prepare Si-Pt nanocomposites (Si-Pt NCs). Results: Si-Pt NCs can produce reactive oxygen radicals (ROS) under ultrasound (US) irradiation, which have sonodynamic therapy (SDT) effect. Meanwhile, Si-Pt NCs can convert excess hydrogen peroxide (H 2 O 2 ) into ROS in the tumor microenvironment, which endow strong chemodynamic therapy (CDT) effect. Taking the advantages of the mesoporous structure of SiNWs, the SDT and CDT effects of Si-Pt NCs are stronger than those of the pure Pt NPs and SiNWs. Besides, the mild photothermal effect of Si-Pt NCs further improves the SDT&CDT activity and realizes the combined cancer therapy. Conclusion: The developed Si-Pt NCs with the ability of photothermal enhanced SDT/CDT combined therapy play a momentous role in the novel cancer treatment.

Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies

“…[ 15 ] Most currently available sonosensitizers are developed from conventional photosensitizers, including organic dyes (e.g., methylene blue, indocyanine green, acridine orange), [ 16–18 ] porphyrin‐derivatives (e.g., photofrin, hematoporphyrin, protoporphyrin IX, [ 19–21 ] and inorganic nanoparticles (e.g., silicon‐based nanoparticles, metal nanoparticles). [ 22–25 ] Yet, only limited SDT trials have entered the early preclinical phases owing to the inadequacies of the extant sonosensitizers in the ROS production, stability under sono‐irradiation, and biocompatibility, thus conferring modest therapeutic efficacy. Therefore, it is highly demanded to develop effective sonosensitizers with stable and sufficient ROS production for in vivo therapeutic applications.…”

Tumor‐specific and photothermal‐augmented chemodynamic therapy by ferrocene‐carbon dot‐crosslinked nanoparticles

“…Integration of therapeutic modalities based on diverse mechanisms has provided opportunities for achieving enhanced anticancer treatment efficacy. [15][16][17] Benefiting from the broad absorption spectrum that could tail up to near-infrared (NIR) region, CDs were regarded as promising candidate for PTT, [18][19][20] which could convert the energy of external light into local heat and consequently leading to carcinoma cell damages. 10,21 PTT exhibited significant advantages in managing precise cancer treatment due to its intrinsic minimal invasiveness, spatiotemporal selectivity, and convenient operation.…”

Gold nanomaterials for oral cancer diagnosis and therapy: Advances, challenges, and prospects

“…Moreover, the combination of AuNPs and appropriate antibodies enhance Raman spectroscopy and detect the diseased tissue faster and more accurately [ 40 , 41 ]. AuNPs have been used in PTT that converts light energy into heat energy in the targeted area of skin and mucous membranes without damaging the surrounding healthy tissues, thereby destroying tumor cells [ [42] , [43] , [44] , [45] ]. AuNPs-based minimum invasive theranostics avoid the risk of surgical wound-related infection in the oral cavity.…”