Biodegradable Chitosan/Multiwalled Carbon Nanotube Composite for Bone Tissue Engineering

Olivas–Armendáriz, I.; Martel-Estrada, Santos-Adriana; Mendoza-Duarte, J.M.; Jiménez-Vega, Florinda; García-Casillas, Perla E.; Martínez-Pérez, Carlos A.

doi:10.4236/jbnb.2013.42025

Cited by 21 publications

(8 citation statements)

References 26 publications

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“…It was observed that composite film conditioned with IPA gave the highest extraction efficiencies for all targeted analytes. This suggested that the non-polar solvent overcame the wettability issue, activated the sorbent, and enhanced the interaction between hydrophobic sorbent and aqueous sample during the extraction procedures [32].…”

Section: Optimization Conditions For Spme Proceduresmentioning

confidence: 99%

“…Multiwalled carbon nanotubes (MWCNTs) are polymers of pure carbon with multiple layers in tubular shape. Incorporation of highly interconnected pores of the MWCNTs in the biopolymer matrix is expected to contribute to increase the hydrophobic sites, surface area and porosity of the materials and thus enhancing the extraction efficiency . The prepared Agr‐Ch‐MWCNT was applied for the first time as sorbent in the SPME for the analysis of three selected NSAIDs (naproxen [NAP], diclofenac sodium salt [DIC], and mefenamic acid [MEF]) in water samples before determination by HPLC–UV.…”

Section: Introductionmentioning

confidence: 99%

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Solid‐phase microextraction based on an agarose‐chitosan‐multiwalled carbon nanotube composite film combined with HPLC–UV for the determination of nonsteroidal anti‐inflammatory drugs in aqueous samples

Ibrahim

Sanagi

Hanapi

et al. 2018

J of Separation Science

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We describe the preparation, characterization, and application of a composite film adsorbent based on blended agarose-chitosan-multiwalled carbon nanotubes for the preconcentration of selected nonsteroidal anti-inflammatory drugs in aqueous samples before determination by high performance liquid chromatography with ultraviolet detection. The composite film showed a high surface area (4.0258 m /g) and strong hydrogen bonding between the multiwalled carbon nanotubes and agarose/chitosan matrix, which prevent adsorbent deactivation and ensure long-term stability. Several parameters, such as sample pH, addition of salt, extraction time, desorption solvent, and concentration of multiwalled carbon nanotubes in the composite film were optimized using a one-factor-at-time approach. The optimum extraction conditions obtained were as follows: isopropanol as conditioning solvent, 10 mL of sample solution at pH 2, extraction time of 30 min, stirring speed of 600 rpm, 100 μL of isopropanol as desorption solvent, desorption time of 5 min under ultrasonication, and 0.4% w/v of composite film. Under the optimized conditions, the calibration curve showed good linearity in the range of 1-500 ng/mL (r = 0.997-0.999), and good limits of detection (0.89-8.05 ng/mL) were obtained with good relative standard deviations of < 4.59% (n = 3) for the determination of naproxen, diclofenac sodium salt, and mefenamic acid drugs.

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Section: Optimization Conditions For Spme Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solid‐phase microextraction based on an agarose‐chitosan‐multiwalled carbon nanotube composite film combined with HPLC–UV for the determination of nonsteroidal anti‐inflammatory drugs in aqueous samples

Ibrahim

Sanagi

Hanapi

et al. 2018

J of Separation Science

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“…Noncovalent interactions are promising to improve polysaccharides properties and compatibility, and ensure long-term stability while retaining their great original properties [85,86]. It is important to understand direction of polymer self-assembly to utilize these interactions.…”

Section: Agarose/chitosan Reinforced and Blended Mwcnt Microextractionmentioning

confidence: 99%

“…Apart from chemical modifications, noncovalent interactions offer simple and effective modifications to meet the requirements for practical applications. Noncovalent interactions are promising to improve polysaccharides properties and compatibility, and ensure long‐term stability while retaining their great original properties . It is important to understand direction of polymer self‐assembly to utilize these interactions.…”

Section: Agarose In Microextraction Techniquesmentioning

confidence: 99%

Agarose‐ and alginate‐based biopolymers for sample preparation: Excellent green extraction tools for this century

Sanagi

Loh

Ibrahim

et al. 2016

J of Separation Science

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Recently, there has been considerable interest in the use of miniaturized sample preparation techniques before the chromatographic monitoring of the analytes in unknown complex compositions. The use of biopolymer-based sorbents in solid-phase microextraction techniques has achieved a good reputation. A great variety of polysaccharides can be extracted from marine plants or microorganisms. Seaweeds are the major sources of polysaccharides such as alginate, agar, agarose, as well as carrageenans. Agarose and alginate (green biopolymers) have been manipulated for different microextraction approaches. The present review is focused on the classification of biopolymer and their applications in multidisciplinary research. Besides, efforts have been made to discuss the state-of-the-art of the new microextraction techniques that utilize commercial biopolymer interfaces such as agarose in liquid-phase microextraction and solid-phase microextraction.

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“…3 CS's compressive modulus has been increased from 1 to 15MPa due to the presence of MWCNTs 26 Increase of Young's modulus at 77% and of ultimate stress at 60% has been achieved by Kroustalli et al 27 Tensile strength of PCL/CNTs electrospun composite fibers can be enhanced from 3 to 8 MPa. 28 Higher modulus of elasticity at 7.1 % of the PLA/PCL/CNT nanocomposite has been achieved in comparison to the pure PCL.…”

mentioning

confidence: 99%

Nanotubes Reinforcement of Degradable Polymers for Orthopedic Applications

Kozaniti

Papanikolaki

Theofanis

et al. 2017

ATROA

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Biodegradable polymers have been studied as scaffolds for bone tissue engineering applications. However, they possess insufficient mechanical properties to be considered as alternatives at sites of increased mechanical loading. To improve their mechanical properties, reinforcing with nanotubes has been investigated, as they reproduce the structure and length scale of bone native topography. The research advances in the use of nanotubes as reinforcing agents in developing nanocomposites with synthetic and natural biodegradable polymers are reviewed. The extent of mechanical reinforcement of the polymers and the corresponding biological response of the nanocomposites are presented.

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Biodegradable Chitosan/Multiwalled Carbon Nanotube Composite for Bone Tissue Engineering

Cited by 21 publications

References 26 publications

Solid‐phase microextraction based on an agarose‐chitosan‐multiwalled carbon nanotube composite film combined with HPLC–UV for the determination of nonsteroidal anti‐inflammatory drugs in aqueous samples

Solid‐phase microextraction based on an agarose‐chitosan‐multiwalled carbon nanotube composite film combined with HPLC–UV for the determination of nonsteroidal anti‐inflammatory drugs in aqueous samples

Agarose‐ and alginate‐based biopolymers for sample preparation: Excellent green extraction tools for this century

Nanotubes Reinforcement of Degradable Polymers for Orthopedic Applications

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