Biodegradable and Elastomeric Poly(glycerol sebacate) as a Coating Material for Nitinol Bare Stent

Abstract

We synthesized and evaluated biodegradable and elastomeric polyesters (poly(glycerol sebacate) (PGS)) using polycondensation between glycerol and sebacic acid to form a cross-linked network structure without using exogenous catalysts. Synthesized materials possess good mechanical properties, elasticity, and surface erosion biodegradation behavior. The tensile strength of the PGS was as high as 0.28 ± 0.004 MPa, and Young's modulus was 0.122 ± 0.0003 MPa. Elongation was as high as 237.8 ± 0.64%, and repeated elongation behavior was also observed to at least three times the original length without rupture. The water-in-air contact angles of the PGS surfaces were about 60°. We also analyzed the properties of an electrospray coating of biodegradable PGS on a nitinol stent for the purpose of enhancing long-term patency for the therapeutic treatment of varicose veins disease. The surface morphology and thickness of coating layer could be controlled by adjusting the electrospraying conditions and solution parameters.

Fracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils

“…It was clear that the surface erosion as confirmed by SEM, also did not alter the gross integrity of the coils (Figure d). This observation is consistent with literature where it has been well‐proven that PGS exhibits minimal swelling . PGS coil compression profile at day 60 of degradation (Figure e) indicated that the load needed to break the coil with radial compression was increased, leading to improved tolerance toward externally applied stress.…”

Drug loaded poly(glycerol sebacate) as a local drug delivery system for the treatment of periodontal disease

“…where n represents the number of active network chain segments per unit volume (mol m À3 ), E 0 represents Young's modulus, R is the universal gas constant, T is the absolute temperature (K). 47…”

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

“…Dissolution rates of the principal bioresorbable materials in physiological conditions. Summary of the dissolution rates of the different materials used in bioresorbable devices and systems at pH 7.4 and 37 °C, namely, a,b) semiconductors, c) metals, d) oxides and nitrides, and e) polymers …”