Fracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils

Abstract

Biodegradable drug-eluting stents (DESs) are used today to treat atherosclerotic arteries and as vehicles to deliver inhibitors to suppress restenosis, with potential applications also in localized cancer therapy. Here the development of a series of drug-eluting poly(glycerol sebacate) (PGS) coils that may find possible use as DESs is reported. PGS is a tough, biodegradable, and biocompatible elastomer that has adjustable mechanical properties thanks to careful control of the fabrication process. Specifically, 3D PGS coils featuring superior mechanical and fracture-resistance properties are fabricated. The surface erosion profile of PGS is designed to further reduce the risk of fragmentation and non-target embolization during the degradation process. A dual-encapsulation mechanism is applied, first poly(ε-caprolactone) microparticles loaded with an anticancer drug Doxorubicin followed by dispersion of these microparticles in the PGS coils, to prolong the release of drug molecules from the interior. Systematic evaluations of the mechanical properties of the PGS coils and their drug release behaviors are conducted. It is anticipated that, these PGS coils may enable minimally invasive delivery using standard endovascular catheters, for achieving localized and sustained release of chemotherapy to tumors, as well as conventional applications in treating vascular disorders.

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A Review: Optimization for Poly(glycerol sebacate) and Fabrication Techniques for Its Centered Scaffolds

“…PGS‐PCL blends are applied widely in the field of cornea tissue, nervous tissue, cardiac patch, vascular grafts, tracheal, drug delivery, and heart valves due to their outstanding properties. [ 95–100 ]…”

“…to treat tumors and cardiovascular diseases. [ 99 ] The doxorubicin which is an extensively used anticancer drug was encapsulated in hydrophobic PCL microparticles. Then microparticles were dispersed inside the relatively hydrophilic PGS coils characterized by homogeneous surface degradation and superior resistance to fracture.…”

“…This dual‐encapsulation mechanisms allowed for controlling drug release for a long time. [ 99 ] It is anticipated that there is great potential for drug‐eluting PGS coils in drug release applications.…”

hiPSC-derived 3D Bioprinted Skeletal Muscle Tissue Implants Regenerate Skeletal Muscle Following Volumetric Muscle Loss

“…Fabrication and characterization of suturable PGS/PCL scaffolds PGS Synthesis: Poly(glycerol sebacate) (PGS) was synthesized using an established protocol. 79 Equimolar quantities of sebacic acid (Sigma-Aldrich) and glycerol (Fisher Scienti c) were mixed using a magnetic stirrer. The mixture was reacted under microwave radiation in 1 minute intervals for a total of 7 minutes at 500 W (Hamilton Beach, VA).…”