A Review: Optimization for Poly(glycerol sebacate) and Fabrication Techniques for Its Centered Scaffolds

Abstract

Poly(glycerol sebacate) (PGS), an emerging promising thermosetting polymer synthesized from sebacic acid and glycerol, has attracted considerable attention due to its elasticity, biocompatibility, and tunable biodegradation properties. But it also has some drawbacks such as harsh synthesis conditions, rapid degradation rates, and low stiffness. To overcome these challenges and optimize PGS performance, various modification methods and fabrication techniques for PGS‐based scaffolds have been developed in recent years. Outlining the current modification approaches of PGS and summarizing the fabrication techniques for PGS‐based scaffolds are of great importance to accelerate the development of new materials and enable them to be appropriately used in potential applications. Thus, this review comprehensively overviews PGS derivatives, PGS composites, PGS blends, processing for PGS‐based scaffolds, and their related applications. It is envisioned that this review could instruct and inspire the design of the PGS‐based materials and facilitate tissue engineering advances into clinical practice.

Different methods of synthesizing poly(glycerol sebacate) (PGS): A review

“…Several reviews have also compiled the research, developments, and applications of PGS and PGS-based materials (Rai et al, 2012;Loh et al, 2015;Halil Murat, 2017;Valerio et al, 2018;Piszko et al, 2021b;Sha et al, 2021;Vogt et al, 2021;Wu et al, 2021;Zulkifli et al, 2022).…”

A breathable and reliable thermoplastic polyurethane/Ag@K2Ti4O9 composite film with an asymmetrical porous structure for wearable piezoresistive sensors

“…For one thing, biodegradable materials including both natural biomaterials (i.e., fiber proteins, cellulose and sugars, 25,26 etc.) and synthetic polymers (i.e., polycaprolactone (PCL), 27,28 polyhydroxybutyrate (PHB) 29 and poly(glycerol sebacate) (PGS), [30][31][32] etc.) have become promising candidates.…”

“…and synthetic polymers ( i.e. , polycaprolactone (PCL), 27,28 polyhydroxybutyrate (PHB) 29 and poly(glycerol sebacate) (PGS), 30–32 etc. ) have become promising candidates.…”

Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol

“…9,10 Even though PGS is highly desirable, there are still challenges associated with it, such as its limited hydrophilicity and high curing temperatures. 11,12 In the structure of PGS, there are hydroxyl groups that allow the incorporation of various functionalities, thus permitting its physiochemical characteristics to be tailored. Therefore, it is possible to modify PGS physically and chemically to improve its properties.…”