Drug loaded poly(glycerol sebacate) as a local drug delivery system for the treatment of periodontal disease

Yang, Bo; Lv, Wei; Deng, Ying

doi:10.1039/c7ra02796f

Cited by 24 publications

(26 citation statements)

References 52 publications

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“…The results matched with those reported by Kim et al on in vitro degradation of PGS in PBS. [58,59] PGS coil compression profile at day 60 of degradation ( Figure 4e) indicated that the load needed to break the coil with radial compression was increased, leading to improved tolerance toward externally applied stress. The change of surface morphology of the coils was also observed from days 0 to 75.…”

Section: Wwwadvancedsciencenewscom Wwwadvtherapcommentioning

confidence: 99%

“…This observation is consistent with literature where it has been well-proven that PGS exhibits minimal swelling. [58,59] PGS coil compression profile at day 60 of degradation ( Figure 4e) indicated that the load needed to break the coil with radial compression was increased, leading to improved tolerance toward externally applied stress. This enhancement could be mainly due to the increase in the porosity and pore size of the PGS structure, which facilitated the enhancement in flexibility of the coils.…”

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confidence: 99%

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Fracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils

Mollazadeh-Moghaddam

Nejad

Chen

et al. 2018

Advanced Therapeutics

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Biodegradable drug-eluting stents (DESs) are used today to treat atherosclerotic arteries and as vehicles to deliver inhibitors to suppress restenosis, with potential applications also in localized cancer therapy. Here the development of a series of drug-eluting poly(glycerol sebacate) (PGS) coils that may find possible use as DESs is reported. PGS is a tough, biodegradable, and biocompatible elastomer that has adjustable mechanical properties thanks to careful control of the fabrication process. Specifically, 3D PGS coils featuring superior mechanical and fracture-resistance properties are fabricated. The surface erosion profile of PGS is designed to further reduce the risk of fragmentation and non-target embolization during the degradation process. A dual-encapsulation mechanism is applied, first poly(ε-caprolactone) microparticles loaded with an anticancer drug Doxorubicin followed by dispersion of these microparticles in the PGS coils, to prolong the release of drug molecules from the interior. Systematic evaluations of the mechanical properties of the PGS coils and their drug release behaviors are conducted. It is anticipated that, these PGS coils may enable minimally invasive delivery using standard endovascular catheters, for achieving localized and sustained release of chemotherapy to tumors, as well as conventional applications in treating vascular disorders.

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Section: Wwwadvancedsciencenewscom Wwwadvtherapcommentioning

confidence: 99%

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confidence: 99%

Fracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils

Mollazadeh-Moghaddam

Nejad

Chen

et al. 2018

Advanced Therapeutics

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“…The PTX/PGSeb nanoparticles showed comparable results to commercial PTX formulations. Yang et al used swelling drug load to charge PGSeb with berberine and chlorhexidine: PGSeb was swelled in ethanol to allow a better diffusion of the drugs and increased permeability [168]. Drug loading had no influence on the mechanical properties of PGSeb (Young's modulus and strain at break) but it did affect the surface wettability.…”

Section: Drug Deliverymentioning

confidence: 99%

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Zamboulis

Nakiou

Christodoulou

et al. 2019

IJMS

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In a century when environmental pollution is a major issue, polymers issued from bio-based monomers have gained important interest, as they are expected to be environment-friendly, and biocompatible, with non-toxic degradation products. In parallel, hyperbranched polymers have emerged as an easily accessible alternative to dendrimers with numerous potential applications. Glycerol (Gly) is a natural, low-cost, trifunctional monomer, with a production expected to grow significantly, and thus an excellent candidate for the synthesis of hyperbranched polyesters for pharmaceutical and biomedical applications. In the present article, we review the synthesis, properties, and applications of glycerol polyesters of aliphatic dicarboxylic acids (from succinic to sebacic acids) as well as the copolymers of glycerol or hyperbranched polyglycerol with poly(lactic acid) and poly(ε-caprolactone). Emphasis was given to summarize the synthetic procedures (monomer molar ratio, used catalysts, temperatures, etc.,) and their effect on the molecular weight, solubility, and thermal and mechanical properties of the prepared hyperbranched polymers. Their applications in pharmaceutical technology as drug carries and in biomedical applications focusing on regenerative medicine are highlighted.

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“…Direct reaction between dicarboxylic acid and glycerol using typical polyesterification catalysts such as (C 4 H 9 ) 2 SnO, Sn(Oct) 2 , Ti(O t Bu) 4 and Ti(OCH(CH 3 ) 2 ) 4 has been shown to result in hyperbranching . Although this is beneficial when synthesizing elastomers for biomedical applications such as scaffolds for tissue engineering, the lack of control and selectivity does not allow for PPM of the elastomers (to enhance characteristics such as water retention capacity) nor allow synthesis of linear functional polyesters . You et al circumvented this problem in the synthesis of poly(sebacoyl diglyceride) through the use of ring‐opening polymerization rather than direct polycondensation of the monomers (Scheme ) .…”

Section: Chemo‐catalytic Synthesis Of Functional Bio‐based Polymersmentioning

confidence: 99%

Post‐polymerization modification of bio‐based polymers: maximizing the high functionality of polymers derived from biomass

Farmer

Comerford

Pellis

et al. 2018

Polymer International

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The renaissance of the bio-based chemical industry over the last 20 years has seen an ever growing interest in the synthesis of new bio-based polymers. The building blocks of these new polymers, so called platform molecules, contain significantly more chemical functionality than their petrochemical counterparts (such as ethene, propene and para-xylene). As a result bio-based polymers often contain greater residual chemical functionality in their chains, with groups such as alkenes and hydroxyls commonly observed. These functional groups can act as sites for post-polymerization modification (PPM), thus further extending the range of applications for bio-based polymers by tailoring the polymers' final properties. This mini-review highlights some of the most recent and compelling examples of how to make use of bio-based polymers with residual functional groups for PPM. It also looks at how the emerging interdisciplinary field of enzymatic polymer synthesis allows for increased functionality in polymers by avoiding side-reactions as a result of milder reaction conditions, and additionally offers an alternative means of polymer surface modification.

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Drug loaded poly(glycerol sebacate) as a local drug delivery system for the treatment of periodontal disease

Abstract: A simple, cost-efficient method to load drugs into poly(glycerol sebacate) polymer. Drugs were able to sustained release for up to 60 days. The drugs loaded polymer showed cytocompatibility and antimicrobial activities.

Cited by 24 publications

References 52 publications

Fracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils

Fracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Post‐polymerization modification of bio‐based polymers: maximizing the high functionality of polymers derived from biomass

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