Biocompatible stimuli responsive superabsorbent polymer for controlled release of GHK-Cu peptide for wound dressing application

Sharma, Shilpa; Dua, Amita; Malik, Amita

doi:10.1007/s10965-017-1254-z

Cited by 22 publications

(11 citation statements)

References 30 publications

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“…To date, SAPs have found their entry in a multitude of applications including diapers, sanitary napkins [39,40], for biomedical purposes (e.g. drug release [39,41], and wound healing [39,42,43]), while hydrogels are more often used for applications in which swelling is less preferred such as in tissue engineering [39,44] or (disposable) contact lenses [45,46]. SAPs are also strongly used in the agricultural sector as soil conditioners, nutrient carriers and water reservoirs (to conserve water in dry areas) [4,[47][48][49][50][51][52][53][54].…”

Section: Overview Of Sap Applicationsmentioning

confidence: 99%

Superabsorbent polymers: A review on the characteristics and applications of synthetic, polysaccharide-based, semi-synthetic and ‘smart’ derivatives

Mignon

Belie

Dubruel

et al. 2019

European Polymer Journal

192

108

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The current review provides an overview of different types of superabsorbent polymers (SAPs) together with appropriate strategies elaborated to enable their synthesis. The main focus will be on polysaccharide-based, semi-synthetic and 'smart' SAPs along with their derivatives. SAPs have already shown their use in a plethora of applications including diapers, the biomedical field, agriculture, etc.The different polymer classification possibilities are discussed, as well as the classification of the constituting building blocks. The main part of SAPs still has a synthetic origin. However, as they are often not biocompatible, biodegradable or renewable, natural SAPs based on polysaccharides have gained increasing interest. Due to the low solubility of synthetic polymers, purification problems or the need for organic solvents, a trend has emerged towards combining polysaccharides with synthetic monomers to create semi-synthetic, hybrid SAPs for specialized applications with fine-tuned properties including wound dressings, fertilizers or self-healing concrete. These specialized, semi-synthetic SAPs offer strong potential for a series of applications in the future. However, future research in this respect is still needed to optimize homogeneity and to increase gel fractions. A final part of this review includes 'smart' SAPs such as SAPs with a T-, electro-and pH-sensitivity. These 'smart' SAPs are especially becoming useful for certain biomedical applications such as drug release for which an in vivo location can be targeted. The use of 'smart', semi-synthetic SAPs with fine-tuned characteristics combining the best characteristics of both synthetic and natural SAPs, offer the greatest potential for the future.

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Section: Overview Of Sap Applicationsmentioning

confidence: 99%

Superabsorbent polymers: A review on the characteristics and applications of synthetic, polysaccharide-based, semi-synthetic and ‘smart’ derivatives

Mignon

Belie

Dubruel

et al. 2019

European Polymer Journal

192

108

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“…Poly(aspartic acid) (pAsp) is a water-soluble and biocompatible polypeptide that has wide applications for agriculture, mineralization, corrosion inhibitor, anti-toxics, super-swelling agent in feminine hygiene products, food packaging and medicinal field [138,139,140]. An amphiphilic multi-arm block copolymer conjugated with Dox via a pH-responsive linker was developed using pAsp as one block (Figure 6).…”

Section: Types Of Ph-responsive Polypeptidesmentioning

confidence: 99%

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

et al. 2019

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Smart nano-carriers have attained great significance in the biomedical field due to their versatile and interesting designs with different functionalities. The initial stages of the development of nanocarriers mainly focused on the guest loading efficiency, biocompatibility of the host and the circulation time. Later the requirements of less side effects with more efficacy arose by attributing targetability and stimuli-responsive characteristics to nano-carriers along with their bio- compatibility. Researchers are utilizing many stimuli-responsive polymers for the better release of the guest molecules at the targeted sites. Among these, pH-triggered release achieves increasing importance because of the pH variation in different organ and cancer cells of acidic pH. This specific feature is utilized to release the guest molecules more precisely in the targeted site by designing polymers having specific functionality with the pH dependent morphology change characteristics. In this review, we mainly concert on the pH-responsive polypeptides and some interesting nano-carrier designs for the effective theranostic applications. Also, emphasis is made on pharmaceutical application of the different nano-carriers with respect to the organ, tissue and cellular level pH environment.

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“…5 The wound healing and antiaging properties of GHK are due probably to its strong affinity for copper ions (Cu 2+ ) to form GHK-Cu complexes. [6][7][8][9][10] Except for formation of the GHK-Cu complexes, protonation is also favored for GHK since the proton affinity of the His side chain is high. [11][12][13] Experimentally and theoretically, there is compelling evidence for formation of nondirectly sequential ions via cyclization/reopening chemistry in the collisioninduced dissociation (CID) spectra of the b n ions when the His residue is near the C-terminus of peptides.…”

Section: Introductionmentioning

confidence: 99%

Mass spectral and theoretical investigations of the transient proton-bound dimers on the cleavage processes of the peptide GHK and its analogues

Wang

Zhang

et al. 2021

RSC Adv.

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Biocompatible stimuli responsive superabsorbent polymer for controlled release of GHK-Cu peptide for wound dressing application

Cited by 22 publications

References 30 publications

Superabsorbent polymers: A review on the characteristics and applications of synthetic, polysaccharide-based, semi-synthetic and ‘smart’ derivatives

Superabsorbent polymers: A review on the characteristics and applications of synthetic, polysaccharide-based, semi-synthetic and ‘smart’ derivatives

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

Mass spectral and theoretical investigations of the transient proton-bound dimers on the cleavage processes of the peptide GHK and its analogues

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