Biocompatible octacalcium phosphate/sodium alginate/silk fibroin composite scaffolds for bone regeneration

Chen, Jiwen; Wang, Huajun; Wu, Yinyin; YouJie, Liu; Shi, Yiwan; Chen, Changshun; Hou, Huige; Zha, Zhengang; Zheng, Xiaofei; Wu, Tingting

doi:10.1016/j.mtcomm.2022.103312

Cited by 6 publications

(4 citation statements)

References 52 publications

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“…The potential of OCP for bone regeneration with rapid cell differentiation was compared with that of calcium phosphates and was found to exhibit the highest capacity for increasing alkaline phosphatase (ALP) activity (Suzuki & Insley, 2020). In fact, a composite scaffold composed of OCP, sodium alginate, and silk fibroin has been assessed for the repair of large bone defects and was found to promote the proliferation and osteogenic differentiation of mouse bone marrow stromal cells in vitro (Chen et al, 2022).…”

Section: Microstructure and Mechanism Of Formation Of Enamel And Bonementioning

confidence: 99%

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Saito

Onuma

Yamakoshi

2023

Genesis

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Summary The cementum is the outermost layer of hard tissue covering the dentin within the root portion of the teeth. It is the only hard tissue with a specialized structure and function that forms a part of both the teeth and periodontal tissue. As such, cementum is believed to be critical for periodontal tissue regeneration. In this review, we discuss the function and histological structure of the cementum to promote crystal engineering with a biochemical approach in cementum regenerative medicine. We review the microstructure of enamel and bone while discussing the mechanism underlying apatite crystal formation to infer the morphology of cementum apatite crystals and their complex structure with collagen fibers. Finally, the limitations of the current dental implant treatments in clinical practice are explored from the perspective of periodontal tissue regeneration. We anticipate the possibility of advancing periodontal tissue regenerative medicine via cementum regeneration using a combination of material science and biochemical methods.

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Section: Microstructure and Mechanism Of Formation Of Enamel And Bonementioning

confidence: 99%

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Saito

Onuma

Yamakoshi

2023

Genesis

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Section: Doping and Its Advantagesmentioning

confidence: 99%

“…Different crystallinity, shape, and stoichiometry in the end products of metal-doped bioceramics and BGs have been achieved by the use of several synthesis techniques ( Srinivasan et al, 2019 ). Methods such as sol-gel ( El-Rashidy et al, 2018 ; Predoi et al, 2019 ; Zhuang et al, 2019 ), chemical precipitation ( Luo et al, 2018 ; Gallo et al, 2019 ; Srinivasan et al, 2019 ; Chen et al, 2022 ), the melt-quenching approach ( Deng et al, 2019 ), magnetron sputtering ( Vranceanu et al, 2019 ), and pulsed laser deposition ( Duta et al, 2019 ) are only a few of the many options. Once bioceramics and BGs have proven to be acceptable as coating materials ( Predoi et al, 2019 ; Vranceanu et al, 2019 ), cements ( Li et al, 2018 ; Zhang and Williams, 2019 ), scaffolds ( Zhao et al, 2014 ; Yin et al, 2018 ; Luo et al, 2019 ; Yuan et al, 2019 ; Zhuang et al, 2019 ), and nanoparticles ( El-Rashidy et al, 2018 ; Chen et al, 2019 ; Morsi and Abd Elhamid, 2019 ; Singh et al, 2020c ), the optimum synthesis process will depend on the application.…”

Section: Doping and Its Advantagesmentioning

confidence: 99%

Design strategies for composite matrix and multifunctional polymeric scaffolds with enhanced bioactivity for bone tissue engineering

et al. 2022

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Over the past few decades, various bioactive material-based scaffolds were investigated and researchers across the globe are actively involved in establishing a potential state-of-the-art for bone tissue engineering applications, wherein several disciplines like clinical medicine, materials science, and biotechnology are involved. The present review article’s main aim is to focus on repairing and restoring bone tissue defects by enhancing the bioactivity of fabricated bone tissue scaffolds and providing a suitable microenvironment for the bone cells to fasten the healing process. It deals with the various surface modification strategies and smart composite materials development that are involved in the treatment of bone tissue defects. Orthopaedic researchers and clinicians constantly focus on developing strategies that can naturally imitate not only the bone tissue architecture but also its functional properties to modulate cellular behaviour to facilitate bridging, callus formation and osteogenesis at critical bone defects. This review summarizes the currently available polymeric composite matrices and the methods to improve their bioactivity for bone tissue regeneration effectively.

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“…In most recent research, SF-based hybrid scaffolds were fabricated by freeze-drying. Not many works focused on the mineralization on 3D printed SF scaffolds with highly porous morphologies and high β-sheet conformation content[ 22 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Extrusion Printed Silk Fibroin Scaffolds with Post-mineralized Calcium Phosphate as a Bone Structural Material

Shi¹,

Cai²,

He³

et al. 2022

IJB

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Artificial bone materials are of high demand due to the frequent occurrence of bone damage from trauma, disease, and ageing. Three-dimensional (3D) printing can tailor-make structures and implants based on biomaterial inks, rendering personalized bone medicine possible. Herein, we extrusion-printed 3D silk fibroin (SF) scaffolds using mixed inks from SF and sodium alginate (SA), and post-mineralized various calcium phosphates to make hybrid SF scaffolds. The effects of printing conditions and mineralization conditions on the mechanical properties of SF scaffolds were investigated. The SF scaffolds from ~10 wt% SF ink exhibited a compressive modulus of 240 kPa, which was elevated to ~1600 kPa after mineralization, showing a significant reinforcement effect. Importantly, the mineralized SF 3D scaffolds exhibited excellent MC3T3-E1 cell viability and promoted osteogenesis. The work demonstrates a convenient strategy to fabricate SF-based hybrid 3D scaffolds with bone-mimetic components and desirable mechanical properties for bone tissue engineering.

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Biocompatible octacalcium phosphate/sodium alginate/silk fibroin composite scaffolds for bone regeneration

Cited by 6 publications

References 52 publications

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Design strategies for composite matrix and multifunctional polymeric scaffolds with enhanced bioactivity for bone tissue engineering

Extrusion Printed Silk Fibroin Scaffolds with Post-mineralized Calcium Phosphate as a Bone Structural Material

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