Chronic kidney disease (CKD) is emerging as one of the major causes of the increase in mortality rate and is expected to become 5th major cause by 2050. Many studies have shown that it is majorly related to various risk factors, and thus becoming one of the major health issues around the globe. Early detection of renal disease lowers the overall burden of disease by preventing individuals from developing kidney impairment. Therefore, diagnosis and prevention of CKD are becoming the major challenges, and in this situation, biosensors have emerged as one of the best possible solutions. Biosensors are becoming one of the preferred choices for various diseases diagnosis as they provide simpler, cost‐effective and precise methods for onsite detection. In this review, we have tried to discuss the globally developed biosensors for the detection of CKD, focusing on their design, pattern, and applicability in real samples. Two major classifications of biosensors based on transduction systems, that is, optical and electrochemical, for kidney disease have been discussed in detail. Also, the major focus is given to clinical biomarkers such as albumin, creatinine, and others related to kidney dysfunction. Furthermore, the globally developed sensors for the detection of CKD are discussed in tabulated form comparing their analytical performance, response time, specificity as well as performance in biological fluids.
Over the past few decades, various bioactive material-based scaffolds were investigated and researchers across the globe are actively involved in establishing a potential state-of-the-art for bone tissue engineering applications, wherein several disciplines like clinical medicine, materials science, and biotechnology are involved. The present review article’s main aim is to focus on repairing and restoring bone tissue defects by enhancing the bioactivity of fabricated bone tissue scaffolds and providing a suitable microenvironment for the bone cells to fasten the healing process. It deals with the various surface modification strategies and smart composite materials development that are involved in the treatment of bone tissue defects. Orthopaedic researchers and clinicians constantly focus on developing strategies that can naturally imitate not only the bone tissue architecture but also its functional properties to modulate cellular behaviour to facilitate bridging, callus formation and osteogenesis at critical bone defects. This review summarizes the currently available polymeric composite matrices and the methods to improve their bioactivity for bone tissue regeneration effectively.
Background: Breast cancer is a leading health problem in females in developing countries. It is associated with various risk factors which are largely preventable. Risk factor awareness and adherence to healthy life style can play a significant role in prevention of cancer. So, study was undertaken to assess the awareness of risk factor of breast cancer and practices of breast self-examination among unmarried females.Methods: A descriptive cross sectional study design was adopted to recruit 150 subjects. Purposive sampling technique was used to enrol unmarried females above 19 years of age. Written informed consent was taken from participants. Interview schedule was constructed, validated and used for data collection. The data was analysed using SPSS version 20.0.Results: Findings of the study revealed that mean age of participant was 22.65±3.21 years. Most of the females were aware that non breast-feeding practices (94.7%), infertility (84.7%), using oral contraceptives pills (50.7%), advancing age (48%), and any trauma to breast (36.7%) are risk factors of breast cancer. Nearly three fourth (76%) of the subjects had good awareness of breast cancer risk factors. However, breast self-examination was only practiced by 14.6% (22) subjects from total 150 subjects.Conclusions: Study concluded that most of the women were aware about the risk factors of breast cancer, however only few were practicing breast self-examination. Since screening and early detection of breast cancer is crucial for cancer control, nurses as health professionals have a significant role to play in early detection and increasing awareness among individuals and communities.
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