Biocompatible nanocomposite of carboxymethyl cellulose and functionalized carbon–norfloxacin intercalated layered double hydroxides

Allou, N’guadi Blaise; Yadav, Archana; Pal, Mintu; Goswamee, Rajib Lochan

doi:10.1016/j.carbpol.2018.01.066

Cited by 50 publications

(31 citation statements)

References 40 publications

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“…For this purpose, three materials such as hyaluronic acid (HA), carboxymethyl cellulose (CMC) and alginate [24,[27][28][29][30][31], that are widely used in biomedical field, were studied. These materials are approved by the United States Food and Drug Administration (FDA) as well as bio compatible and biodegradable materials [32][33][34]. This article discusses the comparison of these three materials by considering their overall aspects, such as geometrical parameters after molding and thermal annealing, piercing capabilities, and dissolution time, to find the most suitable material for microneedle technology.…”

Section: Introductionmentioning

confidence: 99%

Comparison of polymers to enhance mechanical properties of microneedles for bio-medical applications

Bonfante

Lee

Bao

et al. 2020

Micro and Nano Syst Lett

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To pierce through the skin and interact with the first biofluid available, microneedles should be mechanically strong. However, some polymers used to fabricate microneedles yield insufficient strength for the fabrication of arrays (PDMS, highly porous structures, etc.). To enhance mechanical properties, piercing materials can be used. They aim to pierce the skin evenly and dissolve quickly, clearing the way for underlying microneedles to interact with the interstitial fluid (ISF). Three materials-carboxymethyl cellulose (CMC), alginate, and hyaluronic acid (HA)-are discussed in this article. Low concentrations, for a quick dissolution while keeping enhancing effect, are used ranging from 1-5%(w/w) in deionized water. Their overall aspects, such as geometrical parameters (tip width, height, and width), piercing capabilities, and dissolution time, are measured and discussed. For breaking the skin barrier, two key parameters-a sharp tip and overall mechanical strength-are highlighted. Each material fails the piercing test at a concentration of 1%(w/w). Concentrations of 3%(w/w) and of 5%(w/w) are giving strong arrays able to pierce the skin. For the purpose of this study, HA at a concentration of 3%(w/w) results in arrays composed of microneedles with a tip width of 48 ± 8 μm and pierced through the foil with a dissolution time of less than 2 min.

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Section: Introductionmentioning

confidence: 99%

Comparison of polymers to enhance mechanical properties of microneedles for bio-medical applications

Bonfante

Lee

Bao

et al. 2020

Micro and Nano Syst Lett

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“…On the other hand, carboxymethyl cellulose (CMC) is the cellulose derivative which has also significant utilization in cosmetology and as a water retention agent. Additionally, CMC has notable biocompatibility [30,31]. The blending of the above mentioned polymers, PVP-CMC hydrogel scaffold; has been previously successfully prepared in our laboratory.…”

Section: Introductionmentioning

confidence: 99%

“…The blending of the above mentioned polymers, PVP-CMC hydrogel scaffold; has been previously successfully prepared in our laboratory. The biological efficiency of PVP-CMC scaffold has also been found suggestive [30,31,32]. BC is a natural polymer which also has significant biocompatibility and notable mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Biological Efficiency of Inorganic Calcium Filled Bacterial Cellulose Based Hydrogel Scaffolds for Bone Bioengineering

Basu

Saha

Alexandrova

et al. 2018

IJMS

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The principal focus of this work is the in-depth analysis of the biological efficiency of inorganic calcium-filled bacterial cellulose (BC) based hydrogel scaffolds for their future use in bone tissue engineering/bioengineering. Inorganic calcium was filled in the form of calcium phosphate (β-tri calcium phosphate (β-TCP) and hydroxyapatite (HA)) and calcium carbonate (CaCO3). The additional calcium, CaCO3 was incorporated following in vitro bio-mineralization. Cell viability study was performed with the extracts of BC based hydrogel scaffolds: BC-PVP, BC-CMC; BC-PVP-β-TCP/HA, BC-CMC-β-TCP/HA and BC-PVP-β-TCP/HA-CaCO3, BC-CMC-β-TCP/HA-CaCO3; respectively. The biocompatibility study was performed with two different cell lines, i.e., human fibroblasts, Lep-3 and mouse bone explant cells. Each hydrogel scaffold has facilitated notable growth and proliferation in presence of these two cell types. Nevertheless, the percentage of DNA strand breaks was higher when cells were treated with BC-CMC based scaffolds i.e., BC-CMC-β-TCP/HA and BC-CMC-β-TCP/HA-CaCO3. On the other hand, the apoptosis of human fibroblasts, Lep-3 was insignificant in BC-PVP-β-TCP/HA. The scanning electron microscopy confirmed the efficient adhesion and growth of Lep-3 cells throughout the surface of BC-PVP and BC-PVP-β-TCP/HA. Hence, among all inorganic calcium filled hydrogel scaffolds, ‘BC-PVP-β-TCP/HA’ was recommended as an efficient tissue engineering scaffold which could facilitate the musculoskeletal (i.e., bone tissue) engineering/bioengineering.

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“…As effective adjuvants for cancer immunotherapy, multi-target therapeutic vaccines loaded LDHs demonstrated strong dispersion-stable LDH-based vaccine induced cytotoxic T-lymphocyte responses for effective inhibition of melanoma [68]. Recently, Allou et al and colleagues developed an LDH intercalated hybrid NDDP consisting of carboxymethyl cellulose cross linked citric acid and anti-cancer drug norfloxacin (NOR) [69]. NOR release behaviors were investigated, in vitro, under acidic conditions and NDDP showed non-toxicity against human ovarian cancer (PA-1 cell line), suggesting the potential use of nanohybrids as drug carriers [69].…”

Section: Inorganic Nddps Implicated In Anti-cancer Therapymentioning

confidence: 99%

“…Recently, Allou et al and colleagues developed an LDH intercalated hybrid NDDP consisting of carboxymethyl cellulose cross linked citric acid and anti-cancer drug norfloxacin (NOR) [69]. NOR release behaviors were investigated, in vitro, under acidic conditions and NDDP showed non-toxicity against human ovarian cancer (PA-1 cell line), suggesting the potential use of nanohybrids as drug carriers [69]. Another Mg-Al-LDH-MTX-based NDDP has also showed a tremendous potential for anti-cancer drug delivery in vivo [70].…”

Section: Inorganic Nddps Implicated In Anti-cancer Therapymentioning

confidence: 99%

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

Naz

Shamoon

Wang

et al. 2019

IJMS

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Numerous nanoparticles drug delivery systems for therapeutic implications in cancer treatment are in preclinical development as conventional chemotherapy has several drawbacks. A chemotherapeutic approach requires high doses of chemotherapeutic agents with low bioavailability, non-specific targeting, and above all, development of multiple drug resistance. In recent years, inorganic nano-drug delivery platforms (NDDPs; with a metal core) have emerged as potential chemotherapeutic systems in oncology. One of the major goals of developing inorganic NDDPs is to effectively address the targeted anti-cancer drug(s) delivery related problems by carrying the therapeutic agents to desired tumors sites. In this current review, we delve into summarizing the recent developments in targeted release of anti-cancer drugs loaded in inorganic NDDPs such as mesoporous silica nanoparticles, carbon nanotubes, layered double hydroxides, superparamagnetic iron oxide nanoparticles and calcium phosphate nanoparticles together with highlighting their therapeutic performance at tumor sites.

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Biocompatible nanocomposite of carboxymethyl cellulose and functionalized carbon–norfloxacin intercalated layered double hydroxides

Cited by 50 publications

References 40 publications

Comparison of polymers to enhance mechanical properties of microneedles for bio-medical applications

Comparison of polymers to enhance mechanical properties of microneedles for bio-medical applications

Biocompatibility and Biological Efficiency of Inorganic Calcium Filled Bacterial Cellulose Based Hydrogel Scaffolds for Bone Bioengineering

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

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