Biocompatibility and Biological Efficiency of Inorganic Calcium Filled Bacterial Cellulose Based Hydrogel Scaffolds for Bone Bioengineering

Basu, P. K.; Saha, Nabanita; Alexandrova, Radostina; Andonova-Lilova, B.; Georgieva, Milena; Miloshev, George; Sáha, Petr

doi:10.3390/ijms19123980

Cited by 38 publications

(33 citation statements)

References 49 publications

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“…described the synthesis of BC hydrogels incorporated tricalcium phosphate, hydroxyapatite, and calcium carbonate as inorganic fillers to serve as scaffolds in bone tissue engineering. Results according to cell viability study using two different cell lines of human fibroblasts and mouse bone explant cells which demonstrated facilitated growth and proliferation of cells on scaffolds with recommendation as efficient tissue engineering scaffolds in musculoskeletal . Similarly, Zhu et al .…”

Section: Nc In Biomedicinementioning

confidence: 62%

Nature‐derived fibrous nanomaterial toward biomedicine and environmental remediation: Today's state and future prospects

Ngwabebhoh

Yıldız

2019

J of Applied Polymer Sci

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Nanocellulose (NC) among all renewable biopolymers has proven to be one of the most applicable existing nanomaterials, attributed to its fascinating diverse range of physicochemical properties. Herein, this review presents elaborately updates on current research activities focused on developed materials with NC as bycomponent for application particularly in the field of biomedicine and wastewater remediation. A brief introduction on structural properties, production as well as surface features of NC is elucidated. Next, are highlights on usage of nanocellulosic polymeric materials in biomedicine including drug delivery systems, tissue engineering, wound dressing, medical implants and in addition, applications of NC as adsorbent in the field of environmental remediation are also outlined. This section will mainly focus on the consolidation of NC with other additives to develop flexible substrates via incorporation of new functional moieties. Finally, future perspectives as well as main challenges and impediments on working with nanocellulosic‐based materials are explored in an effort to ameliorate the development and effective usage of this nanomaterial in biomedicine and water remediation. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47878.

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Section: Nc In Biomedicinementioning

confidence: 62%

Nature‐derived fibrous nanomaterial toward biomedicine and environmental remediation: Today's state and future prospects

Ngwabebhoh

Yıldız

2019

J of Applied Polymer Sci

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“…The newly produced BC pellicle was then treated with deionized water and the water was refreshed after 2 h of interval until the pH reached a neutral value. Thereafter, a homogenous suspension of BC (particle size: 159 nm (SD: ±11.33)) from the obtained BC mat was prepared by grinding (12 min) the BC mat in distilled water [12,31,50].…”

Section: Methodsmentioning

confidence: 99%

“…“ BC-PVP” hydrogel scaffold was prepared with BC (0.5 g, w / v ≈ 50 mL water based BC) suspension, where PVP (0.5 g, w / v ), PEG (1 g, w / v ), Agar (2 g, w / v ), and glycerin (1 mL, v / v ) were incorporated. The final volume of aqueous polymer solution was made to be 100 mL by adding additional distilled water [31,47].…”

Section: Methodsmentioning

confidence: 99%

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Calcium Phosphate Incorporated Bacterial Cellulose-Polyvinylpyrrolidone Based Hydrogel Scaffold: Structural Property and Cell Viability Study for Bone Regeneration Application

et al. 2019

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This work focuses on the analysis of structural and functional properties of calcium phosphate (CaP) incorporated bacterial cellulose (BC)-polyvinylpyrrolidone (PVP) based hydrogel scaffolds referred to as “CaP/BC-PVP”. CaP is incorporated in the scaffolds in the form of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) in different concentrations (β-TCP: HA (w/w) = 20:80, 40:60, and 50:50). The scaffolds were characterized on the basis of porosity, thermal, biodegradation, mechanical, and cell viability/cytocompatibility properties. The structural properties of all the hydrogel scaffolds show significant porosity. The biodegradation of “CaP/BC-PVP” scaffold was evaluated following hydrolytic degradation. Weight loss profile, pH change, scanning electron microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR) study confirm the significant degradability of the scaffolds. It is observed that a 50:50_CaP/BC-PVP scaffold has the highest degree of degradation. On the other hand, the compressive strengths of CaP/BC-PVP hydrogel scaffolds are found between 0.21 to 0.31 MPa, which is comparable with the human trabecular bone. The cell viability study is performed with a human osteosarcoma Saos-2 cell line, where significant cell viability is observed in all the hydrogel scaffolds. This indicated their ability to facilitate cell growth and cell proliferation. Considering all these substantial properties, CaP/BC-PVP hydrogel scaffolds can be suggested for detailed investigation in the context of bone regeneration application.

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“…For the BC-CMC hydrogels, the presence of HA may influence the network features and might evolve an oxidative stress to the cells, which could in the end result in a major percentage of comets (cells with damaged DNA). 125…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Cellulose-Based Hydrogels in Tissue Engineering Applications

Rusu¹,

Ciolacu²,

Simionescu³

2019

Cellulose Chem. Technol.

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In the last decade, the field of medicine is at the epicentre of recent technological growth and innovation, while major changes have occurred in areas such as tissue engineering, in terms of concepts, knowledge and materials. In this regard, hydrogels are one of the materials of the future, due to their outstanding adaptability, which makes their applications almost endless. These are three-dimensional polymeric networks able to display biomimetic properties, a characteristic that is considered optimal to deliver bioactive principles and engineer injured tissues. Due to their high water content and compatibility with cells, hydrogels may infiltrate into specific or non-specific binding with cell receptors. In addition, with increased concerns about environmental impacts and the emergent request for new eco-friendly materials, researchers are focusing particularly on the application of natural polymer-based hydrogels in the biomedical engineering field, in order to reach non-toxicity, abundance of starting materials, novel features and biomimetic properties. Cellulose and cellulose derivatives represent a class of biopolymers that exhibit the particular capability to participate in different biomedical applications due to their excellent biocompatibility and biodegradability, tunable properties and low cost. This review focuses on the key aspects and recent advances regarding the design, properties and applications of hydrogels based on cellulose and its derivatives, in the broad area of tissue engineering.

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Biocompatibility and Biological Efficiency of Inorganic Calcium Filled Bacterial Cellulose Based Hydrogel Scaffolds for Bone Bioengineering

Cited by 38 publications

References 49 publications

Nature‐derived fibrous nanomaterial toward biomedicine and environmental remediation: Today's state and future prospects

Nature‐derived fibrous nanomaterial toward biomedicine and environmental remediation: Today's state and future prospects

Calcium Phosphate Incorporated Bacterial Cellulose-Polyvinylpyrrolidone Based Hydrogel Scaffold: Structural Property and Cell Viability Study for Bone Regeneration Application

Cellulose-Based Hydrogels in Tissue Engineering Applications

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