Biocompatibility of mineral trioxide aggregate flow and biodentine

Mondelli, José; Hoshino, Roberto Alameda; Weckwerth, Paulo Henrique; Cerri, Paulo Sérgio; Leonardo, Renato de Toledo; Guerreiro-Tanomaru, Juliane Maria; Tanomaru-Filho, Mário; Silva, G F da

doi:10.1111/iej.12989

Cited by 18 publications

(17 citation statements)

References 22 publications

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“…Bioceramic-based materials are highly attractive in dentistry due to their favorable biological and physicochemical properties [1]. Tricalcium silicate-based materials have been widely studied, since these materials promote tissue repair, facilitating the formation of mineralized tissue [2,3]. Although mineral trioxide aggregate (MTA) is a biocompatible material that has been used for various applications such as furcation or root drilling treatment, apical microsurgery, retrofilling, pulp capping, pulpotomy, and root repair [4,5], it has some drawbacks [4].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer

et al. 2021

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Objectives This study evaluated the biocompatibility and bioactive potential of NeoMTA Plus mixed as a root canal sealer in comparison with MTA Fillapex. Materials and Methods Polyethylene tubes filled with NeoMTA Plus ( n = 20), MTA Fillapex ( n = 20), or nothing (control group, CG; n = 20) were inserted into the connective tissue in the dorsal subcutaneous layer of rats. After 7, 15, 30 and 60 days, the specimens were processed for paraffin embedding. The capsule thickness, collagen content, and number of inflammatory cells (ICs) and interleukin-6 (IL-6) immunolabeled cells were measured. von Kossa-positive structures were evaluated and unstained sections were analyzed under polarized light. Two-way analysis of variance was performed, followed by the post hoc Tukey test ( p ≤ 0.05). Results At 7 days, the capsules around NeoMTA Plus and MTA Fillapex had more ICs and IL-6-immunostained cells than the CG. However, at 60 days, there was no significant difference in the IC number between NeoMTA Plus and the CG ( p = 0.1137) or the MTA Fillapex group ( p = 0.4062), although a greater number of IL-6-immunostained cells was observed in the MTA Fillapex group ( p = 0.0353). From 7 to 60 days, the capsule thickness of the NeoMTA Plus and MTA Fillapex specimens significantly decreased, concomitantly with an increase in the collagen content. The capsules around root canal sealers showed positivity to the von Kossa stain and birefringent structures. Conclusions The NeoMTA Plus root canal sealer is biocompatible and exhibits bioactive potential.

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Section: Introductionmentioning

confidence: 99%

Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer

et al. 2021

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“…According to the manufacturer, MTA Flow may be manipulated in different powder/gel ratios, resulting in a smooth consistency, and therefore easy to insert into the site indicated. The presentation of this material seems to be innovative in relation to the other cements available.MTA Flow has an alkaline pH, low solubility, satisfactory radiopacity, biocompatibility and induces biomineralization [32,33]. It is proposed for use in pulp capping, pulpotomy, resorption and perforation repair, apexification, and root-end filling [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Alkalizing properties of new calcium-silicate endodontic biomaterials

Kot

Kucharski

Marek

et al. 2019

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Background: Calcium silicate-based cements (CSC), are self-setting hydraulic biomaterials widely used for reparative procedures in dentistry and endodontics. These materials possess bio-properties like biocompatibility, biointeractivity (release calcium (Ca2+ ) and hydroxyl (OH-) ions), and bioactivity (apatite-forming ability in contact with body fluids). Methods: Six calcium silicate-based materials were selected for this study: TheraCal LC (Bisco Inc. Schamburg, IL, USA), MTA Plus (Prevest Denpro, Jammu, India Avalon Biomed Inc, Bradenton, FL, USA), Biodentine (Septodont, Saint-Maur-des-Fossés, France), RetroMTA (BioMTA, Seoul, Korea), MTA Flow (Ultradent Products, Inc., South Jordan UT, USA), and OrthoMTA (BioMTA, Seoul, Korea). The pH was analysed immediately after immersion (baseline) and after 1 hour, 3 hours, 1 day, 2 days, 3 days, 1 week, 2 weeks, 3 weeks and 1 year with a pH meter, previously calibrated with solutions of known pH. To analyze the change in pH levels of the materials at each time point, 1- and 2-way analysis of variance, ANOVA followed by Tukey's multiple comparison test. The level of significance was set at p < 0.05. Results: Analysis of the tested materials showed statistically significant differences in terms of pH changes as a function of time showed a gradual rise in the pH of all materials. Conclusion: All tested materials exhibited continuous hydroxyl ion release resulting in a rise in pH until the end of time of experience. Because of the highly alkaline pH values of these materials, they possess biointeractivity properties.

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“…Therefore, the performance of these fillers as perforation repair materials has not yet been investigated. It has been shown that both materials tested possess all the biological properties of original MTA but with more advantageous physical and handling properties [13,19,22]. The biocompatibility and bioactivity of the perforation repair material, as well as its dimensional stability over a long period of time, are crucial for the hermetical seal of the perforation site and better success rates of perforation repair [4,22].…”

Section: Discussionmentioning

confidence: 99%

“…The material provides superior handling characteristics and variety of consistencies, a more rapid setting time, resistance to wash-out and is the only MTA repair material that can be delivered in the thin consistency using a 29-G needle [18]. It has been shown that novel material possesses the same biocompatibility and bioactivity as the Biodentine (Septodont) and can be used in a wide range of endodontic procedures, including perforation repair [19].…”

Section: Introductionmentioning

confidence: 99%

Porosity Distribution in Apically Perforated Curved Root Canals Filled with Two Different Calcium Silicate Based Materials and Techniques: A Micro-Computed Tomography Study

et al. 2019

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The present study evaluated the porosity distribution of BioRoot RCS/single gutta-percha point (BR/SC) and MTA flow (MF) fillings, which were used as plugs for the apical perforation repair in curved canals of extracted mandibular molars using micro-computed tomography (μCT). Forty mesial root canals of mandibular first molars were shaped with ProTaper NEXT X1–X5 files 2 mm beyond the apex to simulate apical perforations that were randomly divided into two groups (n = 20) according to the material and technique used for the apical plug: BR/SC or MF. The specimens were scanned before and after canal filling at an isotropic resolution of 9.9 μm. The volumetric analysis of voids in the apical 5 mm of the fillings was performed. Data were analyzed using one-way ANOVA with Bonferroni correction (p < 0.05). Micro-computed tomography (µCT) evaluation revealed significant differences between the groups in terms of porosity: the total volume and percentage volume of voids was lower in the BR/SC group in comparison with the MF group (p < 0.05), with the predominance of open pores in both groups. Neither of the materials and/or application techniques were able to produce void-free root fillings in the apical region of artificially perforated curved roots of mandibular molars.

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Biocompatibility of mineral trioxide aggregate flow and biodentine

Abstract: Although thick MTA Flow induced a less intense inflammatory response, all evaluated materials are biocompatible because they allowed regression of this process after 60 days.

Cited by 18 publications

References 22 publications

Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer

Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer

WITHDRAWN: Alkalizing properties of new calcium-silicate endodontic biomaterials

Porosity Distribution in Apically Perforated Curved Root Canals Filled with Two Different Calcium Silicate Based Materials and Techniques: A Micro-Computed Tomography Study

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