Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer

Hoshino, Roberto Alameda; Delfino, Mateus Machado; Silva, Guilherme Ferreira da; Guerreiro-Tanomaru, Juliane Maria; Tanomaru‐Filho, Mário; Sasso‐Cerri, Estela; Cerri, Paulo Sérgio

doi:10.5395/rde.2021.46.e4

Cited by 12 publications

(13 citation statements)

References 39 publications

(60 reference statements)

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“…Besides biocompatibility, our findings suggest that the TCS + CaWO 4 , Bio-C Repair and MTA HP materials may express a bioactive potential in the connective tissue of rat subcutaneous tissue. In the present study, von Kossapositive structures were seen around TCS + CaWO 4 , Bio-C and MTA HP specimens suggesting the presence of calcium deposits in the capsules (Hoshino et al, 2021;Silva et al, 2015;Viola et al, 2012). Although von Kossa histochemical method reacts with phosphates in calcium deposits, it has been demonstrated that phosphate can be also associated with cations other than calcium (Meloan & Puchtler, 1985).…”

Section: Discussionsupporting

confidence: 59%

Biocompatibility and bioactive potential of an experimental tricalcium silicate‐based cement in comparison with Bio‐C repair and MTA Repair HP materials

et al. 2022

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Aim To evaluate the tissue reaction of a tricalcium silicate‐based repair material associated with 30% calcium tungstate (TCS + CaWO4) in comparison to Bio‐C Repair (Bio‐C; Angelus) and to MTA Repair HP (MTA HP; Angelus). Methodology Polyethylene tubes filled with one of the materials or left empty (control group, CG) were implanted into the subcutaneous tissues of rats for 7, 15, 30 and 60 days (n = 32/group). The capsule thickness, number of inflammatory cells, collagen content, interleukin‐6 (IL‐6), osteocalcin (OCN), von Kossa reaction and analysis under polarized light were evaluated. The data were subjected to generalized linear models for repeated measures, except the OCN. OCN data were submitted to Kruskal–Wallis and Dunn's post hoc test and Friedman followed by Nemenyi's test at significance level of 5%. Results At all time points, significant differences in the number of inflammatory cells were not observed between TCS + CaWO4 and Bio‐C, whereas, at 15, 30 and 60 days, no significant difference was detected between TCS + CaWO4 and MTA HP. At all periods, significant differences were not detected in the number of fibroblasts in TCS + CaWO4 versus MTA HP, and, at 60 days, no significant difference was demonstrated between these groups and CG. Significant differences in the immunoexpression of IL‐6 were not detected amongst bioceramic materials at all periods. From 7 to 60 days, significant reduction in the number of inflammatory cells, number of IL‐6‐immunopositive cells and in the capsule thickness was accompanied by significant increase in the collagen in all groups. OCN‐immunolabelled cells, von Kossa‐positive structures and amorphous calcite deposits were observed around all materials, whereas, in the CG, these structures were not seen. Conclusions These findings indicate that the experimental material (TCS + CaWO4) is biocompatible and has a bioactive potential, similar to the MTA HP and Bio‐C Repair, and suggest its use as a root repair material.

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Section: Discussionsupporting

confidence: 59%

Biocompatibility and bioactive potential of an experimental tricalcium silicate‐based cement in comparison with Bio‐C repair and MTA Repair HP materials

et al. 2022

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“…54,55 Several studies have demonstrated that IL-6 is responsible for the maintenance of inflammatory reaction and, the reduction of this cytokine is associated with tissue connective remodeling, allowing the formation of extracellular matrix components and fibroblasts proliferation. 27,36,38,53,56 In fact, no significant difference in the number of IL-6-immunostained cells and inflammatory cells was observed among the groups, including in the CG specimens, at 60 days, indicating that bioceramic materials are biocompatible.…”

Section: Birefringent Collagen In the Capsulesmentioning

confidence: 86%

“…Despite the highest values of IL‐6‐immunostained cells detected in Bio‐C Pulpo and Biodentine at 7, 15, and 30 days, the significant reduction in the immunoexpression of this cytokine in these groups over time points to a regression in the inflammatory reaction since IL‐6 plays an important role in the recruitment of inflammatory cells from the bloodstream 54,55 . Several studies have demonstrated that IL‐6 is responsible for the maintenance of inflammatory reaction and, the reduction of this cytokine is associated with tissue connective remodeling, allowing the formation of extracellular matrix components and fibroblasts proliferation 27,36,38,53,56 . In fact, no significant difference in the number of IL‐6‐immunostained cells and inflammatory cells was observed among the groups, including in the CG specimens, at 60 days, indicating that bioceramic materials are biocompatible.…”

Section: Discussionmentioning

confidence: 99%

Bioactive potential of Bio‐C Pulpo is evidenced by presence of birefringent calcite and osteocalcin immunoexpression in the rat subcutaneous tissue

et al. 2022

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As the biocompatibility and bioactive potential of repair materials are desired characteristics in dentistry, the tissue response of Bio‐C Pulpo, a bioceramic material launched on the marked by Angelus (Brazil), was compared with Biodentine (Septodont, France) and White MTA (WMTA; Angelus, Brazil). In 32 rats, 148 polyethylene tubes filled with Bio‐C Pulpo, Biodentine or WMTA, and empty (CG, control group) were implanted into subcutaneous tissues for 7, 15, 30, and 60 days. The capsule thickness, numerical density of inflammatory cells (IC) and fibroblasts (Fb), amount of collagen, immunohistochemistry detection of interleukin‐6 (IL‐6) and osteocalcin (OCN), von Kossa and analysis under polarized light were performed. Data were subjected to two‐way ANOVA followed by Tukey's test (p ≤ 0.05). At 7 and 15 days, the capsules around Bio‐C Pulpo were thicker than in WMTA while, at 30 and 60 days, significant differences were not observed among the groups. Although at 7, 15, and 30 days, a greater number of IL‐6‐immunostained cells was found in Bio‐C Pulpo and Biodentine than in WMTA, no significant difference was detected among the groups at 60 days. In all groups, the number of Fb and collagen content increased significantly over time. The capsules around materials exhibited von Kossa‐positive and birefringent structures, and OCN‐immunostained cells whereas, in the CG, these structures were not observed. Bio‐C Pulpo, similarly to Biodentine and WMTA, is biocompatible, allows the connective tissue repair and presents bioactive potential in connective tissue of rats.

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“…The observed inflammatory response lowered more quickly in the NeoMTA Plus group than in the MTA Fillapex group. Also, two of the sealers revealed favorable bioactive capability [ 166 ]. Cytocompatibility of TotalFill BC sealers, a newly introduced bioceramic sealer, was found superior to MTA Fillapex and AH plus.…”

Section: Clinical Applications Of Calcium Silicate Cementsmentioning

confidence: 99%

An Updated Review on Properties and Indications of Calcium Silicate-Based Cements in Endodontic Therapy

Eskandari

Razavian

Hamidi

et al. 2022

International Journal of Dentistry

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Regarding the common use of calcium silicate cements (CSCs) in root canal therapy, their position in the context of past and present dentistry agents can provide a better understanding of these materials for their further improvement. In this context, the present review article addresses a wide range of recent investigations in the field of CSC-based products and describes details of their composition, properties, and clinical applications. The need for maintaining or reconstructing tooth structure has increased in contemporary endodontic treatment approaches. This research thus discusses the attempts to create comprehensive data collection regarding calcium ion release, bond strength, alkalinizing activity and bioactivity, and the ability to stimulate the formation of hydroxyapatite as a bioactive feature of CSCs. Sealing ability is also highlighted as a predictor for apical and coronal microleakage which is crucial for the long-term prognosis of root canal treatment integrity. Other claimed properties such as radiopacity, porosity, and solubility are also investigated. Extended setting time is also mentioned as a well-known drawback of CSCs. Then, clinical applications of CSCs in vital pulp therapies such as pulpotomy, apexification, and direct pulp capping are reviewed. CSCs have shown their benefits in root perforation treatments and also as root canal sealers and end-filling materials. Nowadays, conventional endodontic treatments are replaced by regenerative therapies to save more dynamic and reliable hard and soft tissues. CSCs play a crucial role in this modern approach. This review article is an attempt to summarize the latest studies on the clinical properties of CSCs to shed light on the future generation of treatments.

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Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer

Cited by 12 publications

References 39 publications

Biocompatibility and bioactive potential of an experimental tricalcium silicate‐based cement in comparison with Bio‐C repair and MTA Repair HP materials

Biocompatibility and bioactive potential of an experimental tricalcium silicate‐based cement in comparison with Bio‐C repair and MTA Repair HP materials

Bioactive potential of Bio‐C Pulpo is evidenced by presence of birefringent calcite and osteocalcin immunoexpression in the rat subcutaneous tissue

An Updated Review on Properties and Indications of Calcium Silicate-Based Cements in Endodontic Therapy

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