Biocompatibility and Inflammatory Potential of Titanium Alloys Cultivated with Human Osteoblasts, Fibroblasts and Macrophages

Markhoff, Jana; Krogull, Martin; Schulze, Christian; Rotsch, Christian; Hunger, Sandra; Bader, Rainer

doi:10.3390/ma10010052

Cited by 53 publications

(47 citation statements)

References 70 publications

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“…The IL-6 and IL-8 levels of bare NiTi, GO-coated NiTi, GO/Ag-coated NiTi were significantly higher than the control (P < 0.001). The results are also similar to the results of Lategan et al 52 and www.nature.com/scientificreports www.nature.com/scientificreports/ Markhoff et al 53 . The former studied on the effect of GO nanoparticles (GONPs) on the immune system and that GONPs stimulated IL-6 and IL-10 synthesis by whole blood cell cultures.…”

supporting

confidence: 89%

Corrosion Resistance of Graphene oxide/Silver Coatings on Ni–Ti alloy and Expression of IL-6 and IL-8 in Human Oral Fibroblasts

Srimaneepong

Rokaya

Thunyakitpisal

et al. 2020

Sci Rep

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Graphene based materials (GBMs) have potentials for dental and medical applications. GBMs may cause changes in the levels of cytokine released in the body. this study aimed to study the corrosion resistance of graphene oxide (Go) and Go/silver (Go/Ag) nanocomposite coated nickel-titanium (niti) alloy by electrophoretic deposition and to access the viability of human pulp fibroblasts, and the interleukin (IL)-6 and IL-8 expression level. The bare and coated NiTi samples were characterized by scanning electron microscope (SeM), energy-dispersive X-ray spectroscopy (eDS), Raman spectroscopy, surface profilometry, and X-ray diffraction (XRD). The corrosion resistance of the bare NiTi and coated NiTi samples were investigated by potentiodynamic polarization and electrochemical impedance spectroscopy in 3.5% NaCl solution. The cell viability of human pulp fibroblasts was accessed by the treated culture medium of the bare NiTi and coated NiTi alloys containing 1% fetal bovine serum. IL-6 and IL-8 expression levels were studied by human enzyme-linked immunosorbent assay (ELISA). Data were analyzed using One-way ANOVA (α = 0.05). Both the GO-coated NiTi and GO/Ag-coated NiTi alloys showed better corrosion resistance, a lower rate of corrosion, and higher protection efficiency than the bare NiTi alloy. The coated NiTi alloys were biocompatible to human pulp fibroblasts and showed upregulation of IL-6 and IL-8 levels. Nickel-titanium (NiTi) alloy is widely used due to the special properties of superelasticity and shape memory. Common biomedical applications of NiTi alloys include vascular stents, staples, catheter guide wires, orthodontic wires, and endodontic instruments. However, NiTi alloy exhibits corrosion attack compared to stainless steel, cobalt-chrome, or β-titanium and it results in Ni and Ti ions release. It was found that a significant release of Ni and Ti ions from dental alloys in corrosive environment is noted although the amount of Ni ions release diminish with time 1. Another study found that Ni leaching occurred after placement of the NiTi orthodontic archwires, bands and brackets and was associated with an increase of the Ni ion concentration in the patient's saliva which lasted for 10 weeks and then decreased slowly 2. These ions can cause foreign body reactions, allergy, and adverse reactions in the human body, such as stomatitis, burning sensation, angular cheilitis, and loss of taste 3,4. Similarly, Ni along with Co and Cr remains the most common metals associated with surgical implant failure due to metal sensitization 5. Therefore, the surface modifications and/or coatings have an important role in surface improvement and reducing the corrosion and body reactions. Although various polymer coatings have been tried on NiTi alloy, there has always difficult in making a successful coatings 6,7. Graphene is a sheet of sp 2 carbon atoms that creates a 2-D hexagonal honeycomb structure 8. Graphene based materials (GBMs) have been used for fabricating various nanocomposite coatings to improve surface and me...

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supporting

confidence: 89%

Corrosion Resistance of Graphene oxide/Silver Coatings on Ni–Ti alloy and Expression of IL-6 and IL-8 in Human Oral Fibroblasts

Srimaneepong

Rokaya

Thunyakitpisal

et al. 2020

Sci Rep

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“…According to recent studies, since the 1990s, titanium alloys have been studied and improved with various alloying elements. The authors correlated the values of the mechanical characteristics with X-ray diffraction results and pointed out that low elastic modulus alloys are due to the full presence of the β phase [12]. Types of Ti-based alloys systems in different combination with biocompatible elements: [11].…”

Section: Titanium Alloys Propertiesmentioning

confidence: 99%

“…In medicine, they are used for implant devices that replace hard tissue. Compared to stainless steels and Co-based alloys, titanium alloys have a better biocompatibility [12]. Stainless steels and CoCr alloys are prone to corrosion, releasing metal ions into the body that can cause side effects in dentistry, titanium initial was used for dental implants, and at last years, have been diversified in dental prosthetics and orthodontics.…”

mentioning

confidence: 99%

Biocompatible Titanium Alloys used in Medical Applications

Bălțatu¹,

Tugui²,

Perju³

et al. 2019

Rev. Chim.

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At global level, there is a continuing concern for the research and development of alloys for medical and biomedical applications. Metallic biomaterials are used in various applications of the most important medical fields like orthopedic, dental and cardiovascular. The main metallic biomaterials used in human body are stainless steels, Co-based alloys and Ti-based alloys. Titanium and its alloys are of greater interest in medical applications because they exhibit characteristics required for implant materials, namely, good mechanical properties (less elasticity modulus than stainless steel or CoCr alloys, fatigue strength, high corrosion resistance), high biocompatibility. The aim of this review is to describe and compare the main characteristics (mechanical properties, corrosion resistance and biocompatibility) for latest research of nontoxic Ti alloys biomaterials used for medical field.

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“…Implants made of forged or additively manufactured Ti-6Al-4V provide very good mechanical properties and stability [ 8 ]. Due to its good biocompatibility [ 9 ], i.e., cell compatibility, which is most probably caused by a native oxidation layer on the metal surface [ 10 , 11 ], and its good osseointegration, Ti-6Al-4V is currently used for application in craniofacial [ 12 ], orthodontic [ 8 , 13 , 14 , 15 , 16 ], and orthopedic implants [ 8 , 15 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of a Newly Additive Manufactured Implant Material Based on Ti-42Nb

et al. 2018

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The application of Ti-6Al-4V alloy or commercially pure titanium for additive manufacturing enables the fabrication of complex structural implants and patient-specific implant geometries. However, the difference in Young’s modulus of α + β-phase Ti alloys compared to the human bone promotes stress-shielding effects in the implant–bone interphase. The aim of the present study is the mechanical characterization of a new pre-alloyed β-phase Ti-42Nb alloy for application in additive manufacturing. The present investigation focuses on the mechanical properties of SLM-printed Ti-42Nb alloy in tensile and compression tests. In addition, the raw Ti-42Nb powder, the microstructure of the specimens prior to and after compression tests, as well as the fracture occurring in tensile tests are characterized by means of the SEM/EDX analysis. The Ti-42Nb raw powder exhibits a dendrite-like Ti-structure, which is melted layer-by-layer into a microstructure with a very homogeneous distribution of Nb and Ti during the SLM process. Tensile tests display Young’s modulus of 60.51 ± 3.92 GPa and an ultimate tensile strength of 683.17 ± 16.67 MPa, whereas, under a compressive load, a compressive strength of 1330.74 ± 53.45 MPa is observed. The combination of high mechanical strength and low elastic modulus makes Ti-42Nb an interesting material for orthopedic and dental implants. The spherical shape of the pre-alloyed material additionally allows for application in metal 3D printing, enabling the fabrication of patient-specific structural implants.

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Biocompatibility and Inflammatory Potential of Titanium Alloys Cultivated with Human Osteoblasts, Fibroblasts and Macrophages

Cited by 53 publications

References 70 publications

Corrosion Resistance of Graphene oxide/Silver Coatings on Ni–Ti alloy and Expression of IL-6 and IL-8 in Human Oral Fibroblasts

Corrosion Resistance of Graphene oxide/Silver Coatings on Ni–Ti alloy and Expression of IL-6 and IL-8 in Human Oral Fibroblasts

Biocompatible Titanium Alloys used in Medical Applications

Mechanical Properties of a Newly Additive Manufactured Implant Material Based on Ti-42Nb

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