Biocompatibility and Biodegradation of Chitosan and Derivatives

Halim, Ahmad Sukari; Keong, Lim Chin; Zainol, Ismail; Rashid, Ahmad Hazri Abdul

doi:10.1002/9781119962977.ch4

Cited by 20 publications

(18 citation statements)

References 65 publications

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“…Thermosensitive chitosan derivatives have for instance been prepared by grafting poly(N-isopropyl-acrylamide) onto the chitosan chains [77]. Chitosan can be depolymerized and thermally degraded by hydrolytic cleavage, and is enzymatically degraded in the human body by lysozyme and in the colon by bacterial enzymes [17,78].…”

Section: Chitosan and Chitosan Based Nanoparticlesmentioning

confidence: 99%

Optical-scattering method for the determination of the local polymer concentration inside nanoparticles

Jonassen

Kjøniksen

2011

Phys. Rev. E

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We have developed a method based on the Mie theory for determining the local polymer concentration inside spherical nanoparticles, thereby obtaining vital information about whether the particles are swelling in the solvent or if they are contracted into a more compact structure. In addition, this method can be used to calculate the number density of the particles, the molecular weight of the particles, and (if M(n) of the polymer is known) the aggregation number. The calculations are based on the relationship between the size of the nanoparticles and the turbidity of the sample.

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Section: Chitosan and Chitosan Based Nanoparticlesmentioning

confidence: 99%

Optical-scattering method for the determination of the local polymer concentration inside nanoparticles

Jonassen

Kjøniksen

2011

Phys. Rev. E

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“…Among the different nanotechnology-based adjuvant systems, nanoparticles made of chitosan (CS), a biodegradable polysaccharide [ 5 ], are particularly attractive since these nanoparticles have already proven to be efficient adjuvant systems for a variety of protein antigens [ 6 , 7 ]. In addition to their capacity for associating with peptides and proteins, CS nanoparticles are well known for their ability to efficiently complex polynucleotides, protect them from enzyme degradation, and deliver them to cells [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Poly (I:C)-PADRE Based Nanoparticles as Delivery Vehicles for Synthetic Peptide Vaccines

et al. 2015

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The safety and precision of peptide antigens has prompted the search for adjuvants capable of increasing the immune response against these intrinsically poorly immunogenic antigens. The integration of both immunostimulants and peptide antigens within nanometric delivery systems for their co-delivery to immune cells is a promising vaccination strategy. With this in mind, the potential synergistic effect of the immunostimulant poly (I:C) (pIC) and a T-Helper peptide (PADRE), integrated into a chitosan (CS) based nanostructure, was explored. The value of this nanostructured combination of materials was assessed for a peptide antigen (1338aa) derived from the HPV-16 L2 protein. These nanoparticles, produced by ionic gelation technique, exhibited a nanometric size (<300 nm), a high positive surface charge (>40 mV) and high pIC association efficiency (>96%). They also showed capacity for the association of both the 1338aa and PADRE peptides. The influence of the presence of pIC and PADRE in the nanocomposition, as well as that of the peptide presentation form (encapsulated versus surface adsorbed) on the antibody induction was evaluated in a preliminary in vivo study. The data obtained highlights the possibility to engineer nanoparticles through the rational combination of a number of adjuvant molecules together with the antigen.

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“…CS is a natural cationic polysaccharide, approved for application in wound dressings by the FDA and listed in the pharmacopoeias of many countries. 56 The increasing utilization of chitosan and its derivatives in oral or mucosal drug delivery is based on their superior mucoadhesive properties and penetration-enhancing effects. Quaternized chitosan, one of the CS derivatives, can reverse its positive charge in neutral conditions, which leads to an increase in residence time and bioavailability.…”

Section: Subcutaneous Sustained-release Delivery Systemsmentioning

confidence: 99%

Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment

Li¹,

Long²,

Luo³

et al. 2021

IJN

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Diabetes mellitus is a major threat to human health. Both its incidence and prevalence have been rising steadily over the past few decades. Biomacromolecular agents such as insulin and glucagon-like peptide 1 receptor agonists are commonly used hypoglycemic drugs that play important roles in the treatment of diabetes. However, their traditional frequent administration may cause numerous side effects, such as pain, infection or local tissue necrosis. To address these issues, many novel subcutaneous delivery systems have been developed in recent years. In this review, we survey recent developments in subcutaneous delivery systems of biomacromolecular hypoglycemic drugs, including sustained-release delivery systems and stimuli-responsive delivery systems, and summarize the advantages and limitations of these systems. Future opportunities and challenges are discussed as well.

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Biocompatibility and Biodegradation of Chitosan and Derivatives

Cited by 20 publications

References 65 publications

Optical-scattering method for the determination of the local polymer concentration inside nanoparticles

Optical-scattering method for the determination of the local polymer concentration inside nanoparticles

Chitosan-Poly (I:C)-PADRE Based Nanoparticles as Delivery Vehicles for Synthetic Peptide Vaccines

Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment

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