Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment

Li, Chen; Long, Wei; Luo, Jie; Jiang, Mingyan; Wang, Keke

doi:10.2147/ijn.s283416

Cited by 10 publications

(6 citation statements)

References 131 publications

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“…Administration by injection (parenteral administration) mainly includes subcutaneous (under the skin) and intramuscular (in a muscle) drug delivery [329]. Subcutaneous drug delivery refers to the injection of drugs into the subcutaneous layer of an individual (the layer between the skin and the muscle), and it is commonly used with diabetes and cancer patients [330]. This type of drug delivery approach has been proven to be safe, well tolerated, and effective, and is the first choice for healthcare providers and patients, especially for the delivery of many protein drugs [330].…”

Section: Subcutaneous and Intramuscular (Injection) Drug Deliverymentioning

confidence: 99%

“…Subcutaneous drug delivery refers to the injection of drugs into the subcutaneous layer of an individual (the layer between the skin and the muscle), and it is commonly used with diabetes and cancer patients [330]. This type of drug delivery approach has been proven to be safe, well tolerated, and effective, and is the first choice for healthcare providers and patients, especially for the delivery of many protein drugs [330]. However, the dose of subcutaneous drug delivery is limited to 2 mL.…”

Section: Subcutaneous and Intramuscular (Injection) Drug Deliverymentioning

confidence: 99%

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Emerging Fabrication Strategies of Hydrogels and Its Applications

Ali

Khan

Chen

et al. 2022

Gels

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Recently, hydrogels have been investigated for the controlled release of bioactive molecules, such as for living cell encapsulation and matrices. Due to their remote controllability and quick response, hydrogels are widely used for various applications, including drug delivery. The rate and extent to which the drugs reach their targets are highly dependent on the carriers used in drug delivery systems; therefore the demand for biodegradable and intelligent carriers is progressively increasing. The biodegradable nature of hydrogel has created much interest for its use in drug delivery systems. The first part of this review focuses on emerging fabrication strategies of hydrogel, including physical and chemical cross-linking, as well as radiation cross-linking. The second part describes the applications of hydrogels in various fields, including drug delivery systems. In the end, an overview of the application of hydrogels prepared from several natural polymers in drug delivery is presented.

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Section: Subcutaneous and Intramuscular (Injection) Drug Deliverymentioning

confidence: 99%

Section: Subcutaneous and Intramuscular (Injection) Drug Deliverymentioning

confidence: 99%

Emerging Fabrication Strategies of Hydrogels and Its Applications

Ali

Khan

Chen

et al. 2022

Gels

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“…Many academic research efforts have been focused on developing strategies for sustained insulin release, however, rapid‐acting insulin formulations remain relatively underexplored. [ 14 ] Rapid‐acting insulin analogs are often used in conjunction with continuous infusion pumps to mitigate hyperglycemic episodes by decreasing the time between blood glucose measurements and insulin's systemic effect. [ 15 ] A clinically approved insulin analog, Humalog (insulin lispro) exploits an amino acid sequence mutation to dissociate the stable insulin hexamers into insulin monomers in the subcutaneous space upon injection and formulation dilution, thus allowing for rapid absorption into the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics

et al. 2023

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Proteins are among the most common therapeutics for the treatment of diabetes, autoimmune diseases, cancer, and metabolic diseases, among others. Despite their common use, current protein therapies, most of which are injectables, have several limitations. Large proteins such as monoclonal antibodies (mAbs) suffer from poor absorption after subcutaneous injections, thus forcing their administration by intravenous injections. Even small proteins such as insulin suffer from slow pharmacokinetics which poses limitations in effective management of diabetes. Here, a deep eutectic‐based delivery strategy is used to offer a generalized approach for improving protein absorption after subcutaneous injections. The lead formulation enhances absorption of mAbs after subcutaneous injections by ≈200%. The same composition also improves systemic absorption of subcutaneously injected insulin faster than Humalog, the current gold‐standard of rapid acting insulin. Mechanistic studies reveal that the beneficial effect of deep eutectics on subcutaneous absorption is mediated by their ability to reduce the interactions of proteins with the subcutaneous matrix, especially collagen. Studies also confirm that these deep eutectics are safe for subcutaneous injections. Deep eutectic‐based formulations described here open new possibilities for subcutaneous injections of therapeutic proteins.

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“…[ 2 ] It has been widely adopted due to its advantages of large dose, minimal delay, and high drug bioavailability. [ 8,9 ] However, the injection is a hazardous route for administration, because the drugs may be quickly delivered to the body under uncontrolled conditions, which can cause unexpected side effects. [ 10 ] Moreover, the injection is invasive and can make the patients feel pain and discomfort, especially for the patients with needle phobia.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

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In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

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Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment

Cited by 10 publications

References 131 publications

Emerging Fabrication Strategies of Hydrogels and Its Applications

Emerging Fabrication Strategies of Hydrogels and Its Applications

Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

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