Biocidal properties investigation of the new guanidine-containing alkoxysilanes and siloxanes and epoxy materials modified by them

Tarasenkov, А. N.; Drozdov, Fedor V.; Parshina, Maria S.; Strukova, Elena N.; Cherkaev, G. V.; Музафаров, А. М.

doi:10.1016/j.jorganchem.2021.122211

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Utilizing the amine groups of PHMG for the preparation of methacrylated analogous of PHMG and subsequent free radical polymerization with different monomer is another approach for chemical attachment of active PHMG to wound dressing membranes 27 . Recent studies have reported the preparation of guanidine‐containing alkoxysilyl derivatives, 28 which can be used as biocidal additives in epoxy compositions. These materials have demonstrated high biocidal activity against S. aureus , E. coli , and C. albicans strains.…”

Section: Introductionmentioning

confidence: 99%

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Babaahmadi

Yeganeh

2023

Polymers for Advanced Techs

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The objective of the present study is fabrication of wound dressing membranes with effective antibacterial activity, good biocompatibility with fibroblast cells, appropriate mechanical properties in both dry and wet states to potentially provide physical protection to wounds at different stages of healing, and the ability to maintain an optimum moist environment over the wounded area. To achieve this, a new silane functional polyhexamethylene guanidine hydrochloride was synthesized and utilized as a crosslinker for a polymeric matrix consisting of poly(vinyl alcohol) and gelatin. Thin monolayer films of the resulting polymeric networks were characterized and subjected to different physical and biological assays. The tensile test results indicated that the prepared dressing membranes exhibit good tensile strength in both dry (44 MPa) and hydrated (700 KPa) states. The fluid handling capacity of the dressings was found to be in the range of 2.23 to 2.29 g 10−1 m−2 day−1, which is appropriate for treating wounds with “light” to “moderate” exudate levels. The MTT assay showed excellent biocompatibility, evidenced by high fibroblast cells viability cultured directly over dressings (over 70%) or cultured in media containing the leachates extracted from the dressings (over 90%). Moreover, the dressings exhibited potent antibacterial activity against Staphylococcus aureus (87% killing) and Escherichia coli (99% killing) bacterial strains.

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Section: Introductionmentioning

confidence: 99%

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Babaahmadi

Yeganeh

2023

Polymers for Advanced Techs

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“…Therefore, by proper choice of amine compounds induction of some specific activities is possible. Knowing that guanidinium groups have very good antibacterial activity [35][36][37], introduction of quaternary guanidinium groups in the backbone of MPSiPHU crosslinker through the utilization of guanidine hydrochloride (GHC) as diamine was considered in this work.…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol)-gelatin crosslinked by silane-functionalized guanidyl-hydroxyurethane oligomer as contact-killing non-leaching antibacterial wound dressings

Babaahmadi

Yeganeh

2023

Biomed. Mater.

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The present work aims to prepare efficient wound dressing with noncytotoxicity, proper mechanical strength, and the ability to preserve a hygienic environment over wounded skin tissue. To fulfill this goal, the synthesis of a novel silane crosslinking agent with antibacterial guanidinium chloride functional group is considered. The resulting reagent was applied to make a series of film-type stable crosslinked networks composed of poly(vinyl alcohol) and gelatin. The potential protection of wounds from external forces was confirmed, as these films had a very good tensile strength (16-31 MPa) and good elongation (54-101%) under dry conditions. The good dimensional strength of dressings was preserved after hydration with simulated wound exudates. Based on the calculated fluid handling capacity of the prepared dressings (2.43 to 3.54 g 10-1 cm−2 day−1), they were suitable for treating wounds with ‘light’ to ‘moderate’ exudate volume. All the prepared dressings showed very good biocompatibility, as determined by the high viability of fibroblast cells directly contacted with dressing (over 80%) or leachates extracted from them (over 90%). In addition, dressings functionalized with guanidinium groups could effectively kill representative gram-positive and gram-negative bacterial strains.

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Functional silsesquioxane polymers with branched perfluoroalkyl substituents: Synthesis and prospect applications

Andropova

Drozdov

Shkinev

et al. 2022

European Polymer Journal

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Biocidal properties investigation of the new guanidine-containing alkoxysilanes and siloxanes and epoxy materials modified by them

Cited by 3 publications

References 24 publications

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Poly(vinyl alcohol)-gelatin crosslinked by silane-functionalized guanidyl-hydroxyurethane oligomer as contact-killing non-leaching antibacterial wound dressings

Functional silsesquioxane polymers with branched perfluoroalkyl substituents: Synthesis and prospect applications

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