Biochemical study on the hypoglycaemic effects of extract and fraction of Acacia catechu willd in alloxan-induced diabetic rats

Jarald, E. Edwin; Joshi, Bishal; Jain, Chungath

doi:10.1159/000497675

Cited by 36 publications

(25 citation statements)

References 29 publications

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“…Similar doses exhibited antipyretic activity as well as significant protection against carbon tetrachloride-induced liver damage. The antihyperglycemic activity of an A. catechu ethanolic bark extract has also been demonstrated in alloxaninduced diabetic rats (Jarald et al, 2009). Bhatia et al (2011) have also shown that an ethanol extract of A. catechu hardwood exhibits antihyperglycemic activity in streptozotocin-induced diabetic rats at a dose of 250 mg/kg.…”

Section: Animal Studiesmentioning

confidence: 91%

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Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Stohs

Bagchi

2015

Phytotherapy Research

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Aqueous extracts of Acacia catechu heartwood are rich source of catechin and epicatechin (gallic acid derivatives), with smaller amounts of flavonoids. Extracts have also been prepared with ethyl acetate, ethanol, and methanol, and the properties of these extracts have been studied and are reviewed. Potent antioxidant activity has been well established in both in vitro and in vivo studies. This antioxidant activity is believed to be responsible for the anti-inflammatory, tissue protectant, antineoplastic, and analgesic activities that have been demonstrated and clearly established in animal and cell culture systems. Furthermore, antihyperglycemic, antidiarrheal, antinociceptive, and antipyretic activities have been demonstrated in animal studies. No adverse effects have been observed in animal or human studies or in cell culture systems. In spite of the fact that Acacia products have been used for many years and the general safety of catechins and epicatechins is well documented, few human studies have ever been conducted on the efficacy or safety of A. catechu heartwood extracts. Several studies have shown that a two-ingredient combination product containing A. catechu extract exhibited no adverse effects when administered daily for up to 12 weeks while exhibiting significant anti-inflammatory activity in subjects with osteoarthritis of the knee. There is a need for additional human clinical studies with regard to efficacy and safety.

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Section: Animal Studiesmentioning

confidence: 91%

“…Similar doses exhibited antipyretic activity as well as significant protection against carbon tetrachloride‐induced liver damage. The antihyperglycemic activity of an A. catechu ethanolic bark extract has also been demonstrated in alloxan‐induced diabetic rats (Jarald et al , ).…”

Section: Animal Studiesmentioning

confidence: 98%

Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Stohs

Bagchi

2015

Phytotherapy Research

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“…To determine the presence of alkaloids, glycosides, flavonoids, tannins, steroids, saponins, and carbohydrates, a preliminary phytochemical study with various plants extracts was performed [6][7][8][9].…”

Section: Phytochemical Screeningsmentioning

confidence: 99%

Development of Polyherbal With Antioxidant Activity

Deepak

Jain

2018

Asian J Pharm Clin Res

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Objective: The objective of this research was to develop a polyherbal formulation (PHF) using four different herbs and to evaluate their phytochemicals, physical constants, and determination of their antioxidant activity by DPPH method.Methods: The PHF authenticated herbs were characterized by studying its morphological and pharmacognostic characters. Phytochemical screening showed the presence of alkaloids, glycosides, carbohydrates, amino acid, tannin, steroids, and flavonoids in the combination extract. Physical parameters such as loss on drying (LOD), pH, ash values, LOD, and extractive value have been studied. The antioxidant activity of the combination of extract (100 mg each) was determined using DPPH free radical scavenging method.Results: The results showed that the combination extract has best antioxidant effect at a dose of 400 μg/ml when it was compared with ascorbic acid as the reference standard.Conclusion: The results obtained in this research work clearly showed that the combination extract has best antioxidant effect at a dose of 400 μg/ ml when it was compared with ascorbic acid as the reference standard.

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“…Mice in the APS and Ex + APS groups were fed oral AP (200 mg/kg weight) with a feeding needle one hour before the start of exhaustive exercise to allow enough time for potential AP effects to occur before exercise began (Ex + APS) or the pseudo start time (APS). We selected the dose based on previously published studies [12,13]. The AP used in this study was kindly provided by Amino Up Chemical Co., Ltd. (Sapporo, Japan).…”

Section: Experimental Animals and Sample Processingmentioning

confidence: 99%

Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle

2019

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The purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and levels of skeletal muscle protein carbonyls increased immediately after exhaustive exercise. Exhaustive exercise also decreased liver glutathione (GSH). These results suggest that the exhaustive exercise used in this study induced tissue damage and oxidative stress. Contrary to our expectations, AP supplementation increased plasma AST and alanine aminotransferase activities, liver levels of TBARS, and protein carbonyls. Furthermore, AP supplementation decreased glutathione and glutathione peroxidase activity in the liver. On the other hand, AP supplementation decreased TBARS levels in skeletal muscle. These results suggest that oral high-dose AP administration decreased oxidative stress in skeletal muscle but induced oxidative stress in the liver and increased hepatotoxicity.

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Biochemical study on the hypoglycaemic effects of extract and fraction of Acacia catechu willd in alloxan-induced diabetic rats

Cited by 36 publications

References 29 publications

Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Development of Polyherbal With Antioxidant Activity

Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle

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