Biochemical isthmus [nexus] between type 2 diabetes mellitus and thyroid status—an update

Rajendran, Jayanthi; Srinivasan, Abu Raghavan

doi:10.1016/j.dsx.2019.01.037

Cited by 4 publications

(1 citation statement)

References 51 publications

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“…This parameter is an indicator according to which one can judge the cell penetrability, regulation of fat and protein metabolisms, and also the digestion of mineral substances from the blood by the tissues (Wei et al, 2004). Increase in the content of glucose in the blood of the experimental group of cows indicates an increase in the process of gluconeogenesis, which mainly occurs in the liver, the functioning of which, as described above, is closely related to the correct functioning of the thyroid (Sinha et al, 2014;Jayanthi & Srinivasan, 2019).…”

Section: Discussionmentioning

confidence: 99%

The effect of additive containing an organic form of iodine on the physiological-biochemical parameters of the body of cows

Bogdanova¹,

Алексеев²,

Флерова³

et al. 2020

Regul. Mech. Biosyst.

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Iodine deficiency in soil and water in many countries leads to its low content in plants and animal feed produced from them. The limited intake of this element in animals can lead to endemic diseases. The lack of iodine in animal feeding is most often compensated for by the use of additives with an inorganic form of iodine, which can be poorly absorbed by the body. Feed products with an organic form of iodine have a great biological effect. A study on the effect of iodine-containing additives on the physiological and biochemical parameters of the animal organism was carried out on two groups of 15 cows. The experimental group was fed an organic form of iodine as part of the additive, the control group received an inorganic form of iodine. For all animals during the experiment the biochemical parameters of blood, milk productivity and reproductive ability were studied. During the experiment, an increase in metabolic and redox processes in the body was noted in the experimental group. An increase in mineral metabolism, including iodine content, was found. Due to the sufficient intake of organic iodine in the animals of the experimental group, there was an increase in the activity of the main hepatic enzymes AST and ALT. An increase in the process of gluconeogenesis due to an increase in the glucose content in the blood of experimental cows was revealed. An increase in milk production and reproductive function of animals of the experimental group was established. Within 30 days after the termination of feeding the supplement with the organic form of iodine in the experimental group, a prolonging effect was observed, consisting in higher values of blood biochemical parameters, improved reproductive function and milk productivity relative to equivalent animals in the control. As a result, it was concluded that the use of an additive with an organic form of iodine in the amount of 1.5 g in feeding cows for 60 days increases the iodine content in the blood serum of animals and increases the performance of all types of metabolism, which may indicate the best stimulating effect of the organic form of iodine on thyroid activity glands. This in turn helps to improve the productive and reproductive qualities of animals. To recommend the studied drug as a means to replenish iodine deficiency in animals and to more accurately analyze its effect on the hormone-forming function of the thyroid gland, it is necessary to study the level of thyroid hormones in the blood.

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Section: Discussionmentioning

confidence: 99%

The effect of additive containing an organic form of iodine on the physiological-biochemical parameters of the body of cows

Bogdanova¹,

Алексеев²,

Флерова³

et al. 2020

Regul. Mech. Biosyst.

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RSSDI guidelines on thyroid dysfunction and diabetes

Saboo

Seshadri

Agarwal

et al. 2021

Int J Diabetes Dev Ctries

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Characterization of Fetal Thyroid Levels at Delivery among Appalachian Infants

Crank

Cottrell

Mitchell

et al. 2020

JCM

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Thyroid disorders are a frequently encountered issue during pregnancy and a cause of maternal and fetal morbidity. In regions like Appalachia that are particularly susceptible to health disparities, descriptive studies are needed to assist in identifying pathologic derangements. We sought to characterize fetal thyroid hormone levels at delivery and investigate whether or not maternal demographic characteristics affect the prevalence of neonatal thyroid disease. A cross-sectional analysis was conducted on 130 pregnant women recruited from the Tri-State region, incorporating areas of Kentucky, Ohio, and West Virginia. Total triiodothyronine (T3) (p = 0.4799), free T3 (p = 0.6323), T3 uptake (p = 0.0926), total thyroxine (T4) (p = 0.8316), free T4 (p = 0.0566), and Thyroid stimulating hormone (TSH) (p = 0.8745) levels were comparable between urban and rural newborns. We found no effect of hypertension status or nicotine levels on fetal umbilical cord thyroid hormone levels. Maternal diabetic status was associated with lower T4 (p = 0.0099) and free T4 (p = 0.0025) levels. Cotinine affected levels of T4 (p = 0.0339). In regard to maternal Body Mass Index (BMI), there was an increase in total T3 as BMI increased (p = 0.0367) and no significant difference in free T3, T3 uptake, T4, free T4, or TSH. There was a negative correlation between TSH and 1 min Apgar scores (p = 0.0058). Lead and cadmium have been implicated to alter TSH levels, but no correlation was found in our study (r2 = 0.0277). There were no differences in cord blood between urban (37.3 ± 10.3 fmol/ug DNA) and rural (70.5 ± 26.8 fmol/ug DNA) benzo(a)pyrene DNA adducts (p = 0.174). Thyroid disorders present a unique opportunity for the prevention of perinatal morbidity and mortality, since maternal treatment, as well as maternal demographic characteristics, can have direct fetal effects.

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Biochemical isthmus [nexus] between type 2 diabetes mellitus and thyroid status—an update

Cited by 4 publications

References 51 publications

The effect of additive containing an organic form of iodine on the physiological-biochemical parameters of the body of cows

The effect of additive containing an organic form of iodine on the physiological-biochemical parameters of the body of cows

RSSDI guidelines on thyroid dysfunction and diabetes

Characterization of Fetal Thyroid Levels at Delivery among Appalachian Infants

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