Characterization of Fetal Thyroid Levels at Delivery among Appalachian Infants

Crank, Madison N; Cottrell, Jesse; Mitchell, Brenda; Valentovic, Monica

doi:10.3390/jcm9093056

Cited by 3 publications

(1 citation statement)

References 26 publications

(19 reference statements)

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“…The mean cord blood Free T4 in our study was 0.61 ng/dL, while other studies reported different results (3,37,38). We observed that the mean cord blood Free T4 was signi cantly higher in multigravida newborns than primigravida newborns.…”

Section: Discussioncontrasting

confidence: 79%

Cord Blood TSH and Free T4 Correlation with Maternal and Neonatal Factors and Heel-Stick TSH For the Early Detection of Congenital Hypothyroidism: A Cross-sectional Study in Iran

Sadeghi

Mousavi

Mirmohammadkhani

et al. 2023

Preprint

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Background- Congenital hypothyroidism (CH) is the most frequent cause of mental retardation in children. Despite the success of the screening programs in detecting CH cases, high recalling rate and false positive results impose a burden to the health system worldwide. Although cord blood thyroid stimulating hormone (CBTSH) is an accepted screening tool for CH, data about it are sparse in Iran. Therefore, we aimed to evaluate the umbilical cord blood TSH and Free T4 and its relationship with maternal and neonatal factors, as well as heel-stick TSH. Methods- This study included 120 mother-newborn pairs in Amir-Al-Momenin Hospital, Semnan, Iran from October 2021 to May 2022. The mean values of Free T4 and CBTSH were measured with respect to various maternal and neonatal factors. The heel-stick TSH on day 2-3 after birth were determined in all participants. Results- The mean CBTSH concentration was significantly higher in preterm newborns and male sex than term newborns and females (P=0.039 and P<0.001, respectively). Newborns born via cesarean section had lower CBTSH levels than those born by vaginal deliveries (P=0.040). The CBTSH was also positively correlated with heel-stick TSH (P<0.001). The mean umbilical cord blood Free T4 was significantly higher in multigravida newborns than primigravida cases (P=0.023). There was no statistically significant relation between umbilical cord blood Free T4 and TSH and maternal age, preeclampsia, gestational diabetes, twin or singleton delivery, 1- and 5- minutes Apgar scores, birthweight, and cord gases (P>0.05). The optimal cut-off point of CBTSH for discrimination of suspicious cases to hypothyroidism was 14.75 mIU/L. Conclusions- Method of delivery, gestational age, and male sex were influential variables on the umbilical cord TSH that must be considered when interpreting the results of the CBTSH. This study augments findings that CBTSH may be considered a predictive factor in CH screening programs.

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Section: Discussioncontrasting

confidence: 79%

Cord Blood TSH and Free T4 Correlation with Maternal and Neonatal Factors and Heel-Stick TSH For the Early Detection of Congenital Hypothyroidism: A Cross-sectional Study in Iran

Sadeghi

Mousavi

Mirmohammadkhani

et al. 2023

Preprint

View full text Add to dashboard Cite

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Cross-sectional analysis of maternal and neonatal factors influencing cord blood TSH and free T4 levels in congenital hypothyroidism screening

Sadeghi,

Mousavi,

Mirmohammadkhani

et al. 2024

Discov Med

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Background Congenital hypothyroidism (CH) is the leading cause of cognitive impairment in children. Although screening programs have been successful in identifying cases of congenital hypothyroidism (CH), the high rates of recalling individuals for further testing and the occurrence of false positive results place a significant strain on healthcare systems globally. While cord blood thyroid-stimulating hormone (CBTSH) is commonly used as a screening test for congenital hypothyroidism (CH), there is less data available on its effectiveness in Iran. The objective of this study was to assess the levels of TSH and Free T4 in umbilical cord blood and examine their correlation with maternal and neonatal variables, as well as heel-stick TSH. Methods In this cross-sectional study, 120 mothers and their newborns were recruited from Semnan’s Amir-Al-Momenin Hospital in 2021. The maternal characteristics examined encompassed age, BMI, gravidity (number of pregnancies), history of abortions, preeclampsia, gestational diabetes, gestational age, and delivery technique. The neonatal parameters encompassed in the study were sex, birth weight, number of gestation births, Apgar ratings, and arterial blood cord gases. The average values of Free T4 and CBTSH were measured and compared with these parameters. TSH levels were measured by a heel-stick procedure on days 2–3 following birth. The statistical analysis comprised of the Mann–Whitney U test, Kruskal–Wallis test, and Spearman correlation test. The diagnostic accuracy of CBTSH was evaluated using ROC curve analysis. Results The average concentration of CBTSH was substantially greater in preterm neonates and males compared to term newborns and females (P = 0.039 and P < 0.001, respectively). Newborns delivered by cesarean section exhibited significantly lower levels of CBTSH compared to those delivered vaginally (P = 0.040). A significant positive connection was seen between CBTSH and heel-stick TSH (P < 0.001). The average level of Free T4 in umbilical cord blood was substantially greater in neonates from women who had been pregnant multiple times compared to those who had been pregnant for the first time (P = 0.023). There was no statistically significant correlation observed between umbilical cord blood Free T4 and TSH levels and factors such as maternal age, preeclampsia, gestational diabetes, twin or singleton delivery, Apgar scores, birthweight, and cord gases (P > 0.05). The most effective threshold value for CBTSH in detecting potentially abnormal cases of hypothyroidism was determined to be 14.75 mIU/L. Conclusions Delivery method, gestational age, and male gender were significant factors affecting umbilical cord TSH levels. These factors should be considered when interpreting CBTSH data. This study provides evidence for the inclusion of CBTSH as a predictive factor in CH screening programs.

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The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae

et al. 2022

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Characterization of Fetal Thyroid Levels at Delivery among Appalachian Infants

Cited by 3 publications

References 26 publications

Cord Blood TSH and Free T4 Correlation with Maternal and Neonatal Factors and Heel-Stick TSH For the Early Detection of Congenital Hypothyroidism: A Cross-sectional Study in Iran

Cord Blood TSH and Free T4 Correlation with Maternal and Neonatal Factors and Heel-Stick TSH For the Early Detection of Congenital Hypothyroidism: A Cross-sectional Study in Iran

Cross-sectional analysis of maternal and neonatal factors influencing cord blood TSH and free T4 levels in congenital hypothyroidism screening

The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae

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