Biochemical function of the donor liver in living related liver transplantation

Pszenny, C.; Krawczyk, Marek; Paluszkiewicz, Rafał; Hevelke, Piotr; Zieniewicz, Krzysztof; Grzelak, I; Tomaszewski, Piotr; Kuczyńska, Julita; Pachecka, J

doi:10.1016/s0041-1345(01)02863-9

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…It would be useful to determine the value of the test in evaluating the function of the liver during its various diseases, for the hitherto existing researches [19][20][21] are mainly concentrated on describing, how the test can be used to evaluate the usefulness of the organ for transplantation and to forecast its functions.…”

Section: Discussionmentioning

confidence: 99%

Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function

Piwowarska

Kuczyńska

Pachecka

2004

Journal of Chromatography B

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Section: Discussionmentioning

confidence: 99%

Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function

Piwowarska

Kuczyńska

Pachecka

2004

Journal of Chromatography B

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“…Ozawa et al was able to show that intramitochondrial [NAD + ]/[NADH+H + ] ratio correlates directly with the intrahepatic and arterial [acetoacetate]/[D-(-)-3-hydroxybutyrate] ratio (AKBR). Therefore, the arterial ketone body ratio (AKBR) is a measure of the hepatic intramitochodrial redox potential and hepatic energy charge [ 4 , 5 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatic Mitochondrial Redox Potential in Patients with Liver Metastatic Cancers and Circulatory Insufficiency

et al. 2003

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Arterial ketone body ratio (AKBR), which reflects hepatic intramitochodrial redox potential, was measured in 20 patients with Carcinoma hepatis metastaticum and good circulatory condition (group A), and 16 patients with Carcinoma hepatis metastaticum and chronic cardiogenic circulatory insufficiency (group B). Total ketone body concentration (TKB) and arterial oxygen tension (PaO2) was simultaneously determined. We have stated that AKBR values in both groups of patients were decreased below the normal level. AKBR values in group B were significantly lower than in group A. At the same time TKB values in both groups were statistically equal and significantly increased above the normal level. The levels of arterial oxygen tension (PaO2) in group A were physiologically high, whereas in group B were significantly decreased. Furthermore arterial oxygen tension of patients in group B correlated with AKBR values significantly. In group A we found statistically significant negative correlation between TKB and AKBR values. Our study indicate that the main mechanism which may explain the decrease of intrahepatic mitochondrial redox potential in patients with liver metastatic cancers and good circulatory condition, is the enhanced beta-oxidation of fatty acids, when the efficiency of NAD+ to NADH reduction in beta-oxidation pathway and tricarboxylic acid cycle is higher than re-oxidation of NADH to NAD+ in the oxidative phosphorylation. In patients with coexisting chronic cardiogenic circulatory insufficiency deprivation of blood oxygen supply initiate the irreversible dysfunction of oxidative phosphorylation.

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