Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function

Piwowarska, Jadwiga; Kuczyńska, Julita; Pachecka, J

doi:10.1016/j.jchromb.2004.01.030

Cited by 20 publications

(9 citation statements)

References 17 publications

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“…Subjects taking medications known to induce or inhibit drug metabolism, particularly CYP3A isozymes, were also excluded. To further confirm the assessment of liver function, individuals with liver disease were given a single intravenous dose of lidocaine (1 mg/kg of body weight administered over 3 min) prior to the start of the study and the formation of the metabolite monoethylglycinexylidide (MEGX) was measured at 15 and 30 min (6).…”

Section: Methodsmentioning

confidence: 99%

Effect of Mild and Moderate Liver Disease on the Pharmacokinetics of Isavuconazole after Intravenous and Oral Administration of a Single Dose of the Prodrug BAL8557

Schmitt‐Hoffmann

Roos

Spickermann

et al. 2009

Antimicrob Agents Chemother

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Isavuconazole is a promising new antifungal drug with favorable pharmacokinetic properties and excellent activity against a number of fungi. It is administered as a water-soluble prodrug (BAL8557) that is cleaved by plasma esterases to isavuconazole, which is eliminated primarily by hepatic metabolism. The objective of this investigation was to assess the effect of alcohol-related liver disease on the pharmacokinetics of isavuconazole. Subjects were 16 healthy individuals, 16 with mild liver impairment, and 16 with moderate liver impairment who were randomized to receive a single oral or intravenous dose of BAL8557 equivalent to 100 mg isavuconazole. Blood samples were collected for 21 days following drug administration, and plasma concentrations of isavuconazole, BAL8557, and the cleavage product BAL8728 were measured using high-pressure liquid chromatography coupled with tandem mass spectrometry. Following intravenous administration, the half-life of isavuconazole increased from 123 h for healthy volunteers to 224 h and 302 h for subjects with mild and moderate liver impairment, respectively. The systemic clearance of isavuconazole following intravenous administration decreased from 2.73 liters/h for healthy subjects to 1.43 liters/h for subjects with moderate liver impairment (47.6% decrease [P < 0.05]). A similar decrease (23.5%) was observed after oral administration. These results suggest that a dose adjustment may be needed when isavuconazole is used to treat fungal infections in patients with liver disease.

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Section: Methodsmentioning

confidence: 99%

Effect of Mild and Moderate Liver Disease on the Pharmacokinetics of Isavuconazole after Intravenous and Oral Administration of a Single Dose of the Prodrug BAL8557

Schmitt‐Hoffmann

Roos

Spickermann

et al. 2009

Antimicrob Agents Chemother

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“…The sample was then dissolved in 250 lL of the mobile phase (50 mM KH 2 PO 4 : CH3CN ¼ 4 : 1), mixed using a mixer, and then filtered. Lidocaine concentration levels were measured by high-performance liquid chromatography (HPLC) (Jasco PU-2080 Plus, JASCO, Tokyo, Japan), according to the method reported by Piwowarska et al 19 HPLC conditions detailed in the report of Morota et al 20 are shown in the Table. Typical chromatograms of lidocaine from rabbit bone and mucosa samples are shown in Figure 3.…”

Section: Measurement Of Tissue Lidocaine Levelmentioning

confidence: 99%

Lidocaine Concentration in Oral Tissue by the Addition of Epinephrine

Tanaka¹,

Yoshida²,

Kawaai

et al. 2016

Anesthesia Progress

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The vasoconstrictive effect due to the addition of epinephrine to local anesthetic has been clearly shown by measuring blood-flow volume or blood anesthetic concentration in oral mucosal tissue. However, there are no reports on the measurement of anesthetic concentration using samples directly taken from the jawbone and oral mucosal tissue. Consequently, in this study, the effect of lidocaine concentration in the jawbone and oral mucosal tissue by the addition of epinephrine to the local anesthetic lidocaine was considered by quantitatively measuring lidocaine concentration within the tissue. Japanese white male rabbits (n ¼ 96) were used as test animals. General anesthesia was induced by sevoflurane and oxygen, and then cannulation to the femoral artery was performed while arterial pressure was constantly recorded. Infiltration anesthesia was achieved by 0.5 mL of 2% lidocaine containing 1 : 80,000 epinephrine in the upper jawbone (E þ ) and 0.5 mL of 2% of epinephrine additive-free lidocaine (E 0 ) under the periosteum. At specified time increments (10,20, 30, 40, 50, and 60 minutes), samples from the jawbone, oral mucosa, and blood were collected, and lidocaine concentration was directly measured by high-performance liquid chromatography. No significant differences in the change in blood pressure were observed either in E þ or E 0 . In both E þ and E 0 groups, the serum lidocaine concentration peaked 10 minutes after local anesthesia and decreased thereafter. At all time increments, serum lidocaine concentration in E þ was significantly lower than that in E 0 . There were no significant differences in measured lidocaine concentration between jawbone and mucosa within either the E þ or the E 0 groups at all time points, although the E 0 group had significantly lower jawbone and mucosa concentrations than the E þ group at all time points when comparing the 2 groups to each other. Addition of epinephrine to the local anesthetic inhibited systemic absorption of local anesthetic into the blood such that a high concentration could be maintained in the tissue. Epinephrine-induced vasoconstrictive effect was observed not only in the oral mucosa but also in the jawbone.

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“…After centrifugation, 1.5 mL organic fraction was isolated and depressurized for 10 minutes (408C) to dry and fix by rotary evaporator (EYELA, Tokyo Science Material Co, Tokyo, Japan Japan). 2 The condition of HPLC for this measurement is shown in Table 2. A typical example of the peak lidocaine concentration measured by HPLC is shown in Figure 5.…”

Section: Methods For Analysis Of Lidocaine Concentration In Mandibulamentioning

confidence: 99%

Lidocaine Concentration in Mandibular Bone After Subperiosteal Infiltration Anesthesia Decreases With Elevation of Periosteal Flap and Irrigation With Saline

Ogawa

Watanabe

Kawaai

et al. 2014

Anesthesia Progress

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It has been reported that the action of infiltration anesthesia on the jawbone is attenuated significantly by elevation of the periosteal flap with saline irrigation in clinical studies; however, the reason is unclear. Therefore, the lidocaine concentration in mandibular bone after subperiosteal infiltration anesthesia was measured under several surgical conditions. The subjects were 48 rabbits. Infiltration anesthesia by 0.5 mL of 2% lidocaine with 1 : 80,000 epinephrine (adrenaline) was injected into the right mandibular angle and left mandibular body, respectively. Under several surgical conditions (presence or absence of periosteal flap, and presence or absence of saline irrigation), both mandibular bone samples were removed at a fixed time after subperiosteal infiltration anesthesia. The lidocaine concentration in each mandibular bone sample was measured by high-performance liquid chromatography. As a result, elevation of the periosteal flap with saline irrigation significantly decreased the lidocaine concentration in the mandibular bone. It is suggested that the anesthetic in the bone was washed out by saline irrigation. Therefore, supplemental conduction and/or general anesthesia should be utilized for long operations that include elevation of the periosteal flap with saline irrigation.

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Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function

Cited by 20 publications

References 17 publications

Effect of Mild and Moderate Liver Disease on the Pharmacokinetics of Isavuconazole after Intravenous and Oral Administration of a Single Dose of the Prodrug BAL8557

Effect of Mild and Moderate Liver Disease on the Pharmacokinetics of Isavuconazole after Intravenous and Oral Administration of a Single Dose of the Prodrug BAL8557

Lidocaine Concentration in Oral Tissue by the Addition of Epinephrine

Lidocaine Concentration in Mandibular Bone After Subperiosteal Infiltration Anesthesia Decreases With Elevation of Periosteal Flap and Irrigation With Saline

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